My former lab at the University of Oxford is looking for a postdoc to study ADP-ribosylation and ubiquitination signalling in DNA damage using biochemistry and structural biology. my.corehr.com/pls/uoxrecru... Informal inquiries can be sent to Prof Ivan Ahel via email: [email protected].

After a very "dry" January and a long day in a curriculum development workshop, it was nice to go to the pub last night and celebrate our OER book launch with the librarians who helped us publish. doi.org/10.15131/she... sheffield.pressbooks.pub/hypothesisba... www.sheffield.ac.uk/library/news...

Check out this short book I've co-authored. It's aimed at University staff seeking lab practicals for biosciences students. It contains eight projects with a molecular focus, student-facing materials, and resources for teachers. sheffield.pressbooks.pub/hypothesisba... doi.org/10.15131/she...

Shameless self promotion 😊 Crystal Structure of an Intracellular Subtilisin Reveals Novel Structural Features Unique to this Subtilisin Family www.cell.com/structure/fu...

Happy New Year from snowy Sheffield! 🍾🥂 I hope you enjoyed the festivities and got some nice pressies (I asked Santa for a winning lottery ticket, but alas, he did not oblige ... I guess I must have been a naughty boy 😨).

Deadline today, January 6th! Two PhD studentships with us - fully funded and open to students worldwide. Come help us learn more about our favourite #Cdiff #phage

There is ONE WEEK left to apply for the #PlantScience #PhD position in my lab! This will use the latest #microscopy, #biosensor and #ecophysiology techniques!

Interested in ADP-ribosylation? Technology Networks has published a short news article I wrote to describe the results and implications from my latest published research. www.technologynetworks.com/tn/articles/... doi.org/10.1016/j.jb...

We have a #PhD available! I'm really excited about this project, looking at whether and how differences in the #IDRs of paralogous epigenetic enzymes CBP and p300 cause them to behave differently. www.findaphd.com/phds/project...

1. I feel like this is such obvious advice that it gets taken for granted & consequently no one says this to young scientists but READ PAPERS, read all the papers. As you move up in your career you will have less & less time to do this. Read everything that appeals to you not just in your field

Unlocking the secrets of metastasis: Cancer cells' 'eating' ability could lead to new treatments medicalxpress.com/news/2024-12... via #medical_xpress

Shameless self promotion 😊 Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi www.sciencedirect.com/science/arti...

Shameless attempt of self-promotion 😊 Specificity of the trypanothione‐dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme onlinelibrary.wiley.com/doi/10.1111/...

Excited to see our paper in press today at HGG Advances!!! We described a new variant in #ADPRS gene in individuals with CONDSIAS, disrupting its #ARH3 protein function leading to increased #ADP-ribosylation in cells. bit.ly/3OmvwqH

A viral ADP-ribosyltransferase attaches RNA chains to host proteins (2023). www.nature.com/articles/s41...

ADP-ribosylation from molecular mechanisms to therapeutic implications

New paper published! 😊 Nucleosomes, ADP-ribosylation, a chromatin remodeler, smFRET, cryoEM. And the best of all: it confirmed a hypothesis we posited in our previous paper in 2021! Super nice to finally see this new paper out. 🤩 🧬🧶 doi.org/10.1038/s414...

Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I onlinelibrary.wiley.com/iucr/doi/10....

Ignore this, it's a test to see if metric sites can pick up this mention or not (my earlier post seems to have been ignored by them) Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA (#RAD51 homologue) academic.oup.com/nar/article/...

#OpenAccess Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA (#RAD51 homologue): t.co/fpbNDxUTeS