Joel Geerling
@geerling-lab.bsky.social
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Neuroanatomy - Cognitive & Behavioral Neurology - Iowa Neuroscience Institute
Very cool paper — Ten1/Lphn2 expression gradients in the developing brain may be responsible for polysynaptic wiring topography across multiple brain systems (cerebellum, basal ganglia, visual and auditory brainstem).
www.biorxiv.org/content/10.1...
4 months ago
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reposted by
Joel Geerling
Erik Herzog
6 months ago
Follow this link to advocate for research, especially on model organisms.
www.fda.gov/news-events/...
add a skeleton here at some point
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Whole-brain tracing of axonal projections from prefrontal cortex in monkey (via fMOST serial confocal imaging). AI template followed by manual, touch-up tracing by “more than 100…annotators,” working a few microns at a time. Unsettlingly impressive.
t.co/cowyQJbujt
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https://www.cell.com/cell/fulltext/S0092-8674(25)00639-7
https://t.co/cowyQJbujt
6 months ago
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reposted by
Joel Geerling
Gord Fishell
6 months ago
Here is a chat with Bosilijka Tasic and myself about the enhancer-mediated AAVs that we were both centrally involved in publishing. I truly believe these approaches are fundamentally important for both basic and clinical approaches!
braininitiative.nih.gov/news-events/...
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From the BRAIN Director: Q&A With Dr. Gordon Fishell and Dr. Bosiljka Tasic on Precise Brain Cell Delivery Systems | BRAIN Initiative
Newly published work funded by the NIH BRAIN Initiative offers a precision toolkit for accessing cells in the brain and spinal cord with unprecedented accuracy. The new delivery tools, about 1,000 in ...
https://braininitiative.nih.gov/news-events/blog/brain-director-qa-dr-gordon-fishell-and-dr-bosiljka-tasic-precise-brain-cell?utm_source=BRAIN+Blog&utm_medium=email&utm_campaign=Armamentarium+Q%26A+Email
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Thank you to all who served and sacrificed for our freedom. (Iowa City VA this morning)
7 months ago
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An MSL for a famous drug company just sent me an email with the line “You know the drill…” Yes, I do know the drill. It’s called rebranding sales reps to bypass University and hospital ethics restrictions while pretending otherwise.
10 months ago
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Delayed neurodegenerative symptoms in a PSEN2 carrier (dominantly inherited Alzheimer’s “escapee”). Despite tons of amyloid plaque, tau pathology delayed >10y. Analogous to PSEN1 patients with APOE3-Christchurch homozygosity (2019) & RELN-COLBOS (2023).
www.nature.com/articles/s41...
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Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia - Nature Medicine
A rare case of asymptomatic dominantly inherited Alzheimer’s reveals confined tau pathology and unique proteomic features, highlighting potential resilience mechanisms decades beyond expected onset.
https://www.nature.com/articles/s41591-025-03494-0
11 months ago
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reposted by
Joel Geerling
OpenBehavior
11 months ago
Researchers from the Champalimaud Foundation have shared an open-source lickometer that uses optical fibers for precise lick detection and includes an integrated nosepoke detector and LEDs for visual cue. Read about it in this week's post on OpenBehavior:
edspace.american.edu/openbehavior...
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High-Precision Optical Fiber-Based Lickometer
Visit the post for more.
https://edspace.american.edu/openbehavior/project/high-precision-optical-fiber-based-lickometer/
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reposted by
Joel Geerling
Kate Ellacott
11 months ago
Fluorescence Friday - combined RNAscope for GHS-R and immunoreactivity for GFAP and NEUN in the dorsal vagal complex. We are RNAscope newbies and very proud of Katherine Pye for setting this up from scratch in the lab. Apologies for wonky orientation - just run out of steam on Friday!
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Dear professional and scientific associations: please stop sending emails explaining that you don’t know what is happening or what will happen next.
11 months ago
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reposted by
Joel Geerling
NEJM.org
12 months ago
𝐍𝐨𝐭𝐚𝐛𝐥𝐞 𝐀𝐫𝐭𝐢𝐜𝐥𝐞𝐬 𝐨𝐟 𝟐𝟎𝟐𝟒 In the FINEARTS-HF trial, finerenone resulted in a lower rate of total worsening heart failure events and death from cardiovascular causes than placebo, marking a notable benefit with respect to its primary end point. Full trial results:
nej.md/470x4ix
#MedSky
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Lovely video about recent work from the Buzsáki lab at NYU. Accessible explanation of manifold concept (transforming 100s of recordings into a low-dimensional manifold), which reveals the replay of salient spatial patterns (w/ripples) during sleep.
youtu.be/ceFFEmkxTLg?...
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How Your Brain Chooses What to Remember
YouTube video by Artem Kirsanov
https://youtu.be/ceFFEmkxTLg?si=dyaYp0uO0FGi9tXh
12 months ago
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reposted by
Joel Geerling
Shannon Macauley
12 months ago
Cool paper. Hyperphosphorylated tau causes issues at the synapse & w/ behavior in new mouse model. No tangles necessary.
www.nature.com/articles/s41...
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In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds - Nature Neuroscience
Mice expressing humanized mutant tau exhibit synaptic loss and behavioral abnormalities in the absence of abnormal tau conformers, suggesting that hyperphosphorylated tau can be pathological, at least...
https://www.nature.com/articles/s41593-024-01829-7
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Interesting read. Also the first example I’ve seen of authors picking a fight with @elonmusk in a high-profile Neuroscience journal: “The unbearable slowness of being: Why do we live at 10 bits/s?”
t.co/1EfDKbXjFU
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https://www.cell.com/neuron/fulltext/S0896-6273(24)00808-0
https://t.co/1EfDKbXjFU
about 1 year ago
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Heartbreaking and inspiring. Best news article I’ve ever read about FTLD (MAPT, familial):
www.nytimes.com/2024/12/22/h...
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A Woman With a Rare Gene Mutation Fights to Avoid Her Mother’s Fate
A mutant gene is coming to steal Linde Jacobs’s mind. Can she find a way to stop it?
https://www.nytimes.com/2024/12/22/health/frontotemporal-dementia-genetic-mutation-linde-jacobs.html?smid=nytcore-ios-share&referringSource=articleShare
about 1 year ago
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reposted by
Joel Geerling
Dr. Cate Peña
about 1 year ago
Nothing says cozy reading by the fireplace like our new review, “Molecular heterogeneity and development of the VTA” Thanks
@bensaunders.bsky.social
and
@bellonec.bsky.social
for the invitation to contribute to this special issue on
#Dopamine
!
authors.elsevier.com/a/1kIwj8MqMi...
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It was lovely to have everyone in the Resch and Geerling labs together for a holiday dinner.
about 1 year ago
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about 1 year ago
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Hello, Bluesky!
about 1 year ago
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you reached the end!!
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