Check out our new preprint in which we teamed up with the Walter and Chen labs to determine how transcription coordinates the folding and function of a tandem aptamer glycine riboswitch from B. subtilis: www.biorxiv.org/content/10.1...

Our paper describing a method for measuring cotranscriptional RNA folding using high-throughput RNA chemical probing is out @natcomms.nature.com!

Tool - 10,000 Days and Fear Inoculum both qualify.

Here is our paper showing in vivo folding of nascent RNA right after synthesis, published now in @cp-molcell.bsky.social! With @karlaneugebauer.bsky.social, @isaac-vock.bsky.social, @mattdsimon.bsky.social www.cell.com/molecular-ce...

I'm excited to share our latest publication on co-transcriptional RNA folding in a eukaryote! Great work by Leo Schärfen with collaboration from Isaac Vock and Matt Simon! @leoschaerfen.bsky.social @mattdsimon.bsky.social Take a peek here authors.elsevier.com/a/1kpxo_Oylr...

I'm excited to share our latest publication on co-transcriptional RNA folding in a eukaryote! Great work by Leo Schärfen with collaboration from Isaac Vock and Matt Simon! @leoschaerfen.bsky.social @mattdsimon.bsky.social Here is the link that works! authors.elsevier.com/a/1kpxo_Oylr...

Yup. I use SABIAN cymbals and inquired about getting some prototypes through SABIAN's Sound Check program in January. I was told that the program was on hold for the US until the uncertainty regarding tariffs is resolved. Glad I'm already set up with all the catalog cymbals I want for now...

BOOM! US tariffs could crash the market for North American drummers, writes PIIE's Cullen Hendrix www.piie.com/blogs/realti...

Our paper describing our Transcription Elongation Complex Display platform for high-throughput cotranscriptional RNA functional assays is now online at @naturecomms.bsky.social: www.nature.com/articles/s41.... We used TECdisplay to assess the activity of >1M ZTP riboswitch variants!

It's my great pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture. If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)

I haven't seen a nucleic acids starter pack yet, so I started one! Please reach out if I missed you! go.bsky.app/NxKgUY5

Our latest preprint, led by Skyler Kelly: we developed a platform for high-throughput cotranscriptional RNA biochemistry called Transcription Elongation Complex display. www.biorxiv.org/content/10.1...

The final version of our article describing a modernized procedure for cotranscriptional RNA structure probing is online! www.nature.com/articles/s41...

Paper data for an assay I dreamed up in 2018 👀