Fascinating paper suggesting the assumption that there is a sigmoid dose response relationship and threshold effect ( "all-or-nothing") for loop diuretics rests on repeated misinterpretation of original studies from the 70s and 80s. #nephsky #cardiosky #emimcc academic.oup.com/ehjcvp/artic...

At 23 years of follow-up, population-based PSA screening of asymptomatic men led to a sustained reduction in prostate cancer mortality, although overdiagnosis remains a concern. Full ERSPC study results and Research Summary: nej.md/42YYsg7  #MedSky #Oncology

Among patients with atherosclerosis or diabetes but no previous myocardial infarction or stroke, evolocumab led to a lower risk of major adverse cardiovascular events than placebo. Full VESALIUS-CV trial results: nej.md/4oWrIN6 #AHA25

In a meta-analysis of 17,801 patients with myocardial infarction and preserved LVEF (≥50%), beta-blockers did not reduce death, MI, or heart failure over a median 3.6 years of follow-up. Full results: nej.md/43U5Ppo #AHA25

New living clinical practice guideline: Cardiovascular, kidney related, and weight loss effects of therapeutics for type 2 diabetes See our #BMJInfographic for a visual summary of the recommendations www.bmj.com/content/390/...

Happy 276th birthday Edward Jenner! What a time for vaccination: 154 million lives saved in the last 50 years, tempered with an increase in vaccine preventable diseases across the world, vaccine sceptics in charge in the US, and cuts to overseas aid threatening global immunisation programmes.

Exceptionally clear and informative resource.

The risk of venous thromboembolism (VTE) varies across contemporary hormonal contraceptives, with the highest risk associated with combined pills. #MedSky https://ja.ma/3Y5WQPf

Terminally Ill Adults (End of Life) Bill: call for evidence here's mine margaretmccartney.substack.com/p/terminally... www.parliament.uk/business/new...

Paper in this week's NEJM shows that in patients with atrial fibrillation and stable coronary artery disease, edoxaban monotherapy is superior to the combination of edoxaban plus an antiplatelet drug. Major difference was in bleeding rather than reduction in ischaemic events.

Oral HRT increases venous thrombotic risk (VTE). Tibolone increases arterial but not VTE risk. Topical HRT showed no increase in either. Huge prospective Swedish study: 919,614 women of whom 77,512 started HRT. tinyurl.com/85jxatux #HRT

Disagree. It’s not the NICE decision that’s disappointing , it’s the drug https://www.ft.com/content/7762094c-a86d-43ac-9ed7-fc74ead4c5c5

Excellently articulated opinion piece from former PM Gordon Brown.

Trending in the wrong direction... #AMR #WAAW24 #PharmSky pharmaceutical-journal.com/article/news...

MEGA PDF on Incretin therapies by the one and only @drkevinfernando.bsky.social Very topical at the moment for CRM world #PharmSky #Medsky #GPsky #CRM #CardioSky img.medscapestatic.com/vim/live/pro...

Excited to share our recent publication exploring a path forward to retire Cockroft Gault and move towards universal eGFR-based medication dosing decisions, a monumental effort led by Wendy St. Peter and the @nkf-professionals.bsky.social doi.org/10.1093/ajhp...

CLEAR trial: Should we routinely use Spironolactone after Acute Myocardial Infarction? No! #AHA2024 www.nejm.org/doi/full/10....

GOLD 2025 guidance now available. No dramatic changes to pharmacological management of COPD from my reading. #PharmSky #COPD goldcopd.org/2025-gold-re...

Interesting conclusion from Cochrane. Are we currently over treating BP in this cohort? Thoughts? #PharmSky #Pharmacy

SUMMIT trial: “Treatment with tirzepatide led to a lower risk of a composite of death from cardiovascular causes or worsening heart failure than placebo and improved health status in patients with heart failure with preserved ejection fraction and obesity” www.nejm.org/doi/full/10....

BPROAD trial: “Among patients with T2 diabetes, the incidence of major CVD events was significantly lower with intensive treatment targeting a systolic blood pressure of <120 mm Hg than with standard treatment targeting a systolic blood pressure of <140 mm Hg” www.nejm.org/doi/full/10....

Good piece on the problems around drug choice in assisted suicide unherd.com/2024/11/the-...

Partisan prophecy: God warning powerless people of their fate if they do not support and defend the cause of the right people in power. Biblical prophecy: God warning those in power of their fate if they do not support and defend the cause of powerless people.

I understood that BlueSky was supposed to be a 'safer' space than X... On browsing feeds on Christianity/religion, perhaps this is not a safe space after all! Is there space for people of faith to encourage each other here, or should we move elsewhere?! #christianity #religion #christian