Chris am Ende
@chrisamende.bsky.social
๐ค 444
๐ฅ 63
๐ 1
Chemical Biology and Medicinal Chemistry
#PFEColleague
reposted by
Chris am Ende
Nicholas Ball
6 months ago
SuFEx welcomes new coupling partners - carbon pronucleophiles now in
@chemicalscience.rsc.org
. Congrats to Ball Lab students Joe Novicku and Matt Teeter and Pfizer colleagues Alistair, Tom, Neil, ans
@chrisamende.bsky.social
on the great work!
#MyFirstChemSci
pubs.rsc.org/en/content/a...
loading . . .
Sulfur fluoride exchange with carbon pronucleophiles
Aryl alkyl sulfones are an important class of compounds in drug discovery; thus, new methods toward their synthesis are desirable. A general sulfur fluoride exchange (SuFEx) method to couple aryl sulf...
https://pubs.rsc.org/en/content/articlelanding/2025/sc/d5sc03893f
1
10
5
reposted by
Chris am Ende
Nicholas Ball
about 1 year ago
Just completed a three-month sabbatical Groton, CT site with
@chrisamende.bsky.social
. I had a great time working with excellent colleagues (including
@bagphos.bsky.social
) and learning a lot of new chemistry. Thanks so much!
2
10
1
reposted by
Chris am Ende
Peter Kenny
about 1 year ago
Opportunity in chemical biology &
#proteomics
at Pfizer (Groton CT USA) ref: 4924293 | closing: 06-Dec-2024
#ChemBiol
#biochem
#chemsky
๐งช
pfizer.wd1.myworkdayjobs.com/PfizerCareer...
loading . . .
Senior Scientist, Chemical Biology and Proteomics
Would you like to discover the medicines of the future? At Pfizer we deliver Breakthroughs That Change Patients Lives. In the Chemical Biology and Proteomics group, we play a vital role in this missio...
https://pfizer.wd1.myworkdayjobs.com/PfizerCareers/job/United-States---Connecticut---Groton/Senior-Scientist--Chemical-Biology-and-Proteomics_4924293-2
0
26
16
reposted by
Chris am Ende
Nicholas Ball
about 1 year ago
Check out the latest from our lab's @theballlab in @JOC_OL Lewis Acid-Catalyzed Sulfur Fluoride Exchange.
pubs.acs.org/doi/10.1021/...
loading . . .
Lewis Acid-Catalyzed Sulfur Fluoride Exchange
A new method uses metal Lewis acids as catalysts to convert sulfonyl fluorides, fluorosulfates, and sulfamoyl fluorides with silyl amines into SโN bond-containing compounds via sulfur fluoride exchange. The reaction successfully employs Ca(NTf2)2 as a catalyst to form sulfonamides, sulfamates, and sulfamides using in situ-generated or commercially available silyl amines in 35โ99% yields. Other metal Lewis acids are also demonstrated to be catalysts in SuFEx, forming sulfonamides and sulfamates in yields comparable to those of Ca(NTf2)2.
https://pubs.acs.org/doi/10.1021/acs.orglett.4c03726
1
19
5
reposted by
Chris am Ende
Neel Shah
about 1 year ago
Exciting NYAS symposium on the Chemical Biology of Nucleic Acids happening on January 14th, with an awesome speaker lineup from academia and industry. Submit an abstract if you want to present a poster or potentially get selected for a short talk!
bit.nyas.org/4furecg
loading . . .
Chemical Biology of Nucleic Acids
Join me for this event: Chemical Biology of Nucleic Acids
https://bit.nyas.org/4furecg
0
3
3
you reached the end!!
feeds!
log in