RoseMarie Akiki
@rosemarieakiki.bsky.social
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📥 69
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MD/PhD candidate at MUSC, molecular neuroscientist. Étranger
An honor to have such great mentors
@makototaniguchi.bsky.social
and Dr. Cowan! Very proud to be an alumna from their labs!
add a skeleton here at some point
9 months ago
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reposted by
RoseMarie Akiki
Makoto Taniguchi
9 months ago
Our study, led by
@rosemarieakiki.bsky.social
, reveals how long non-coding RNAs translate emotional experience into immediate early gene expression through R-loops and 3D chromatin loops.
www.science.org/doi/10.1126/...
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A long noncoding eRNA forms R-loops to shape emotional experience–induced behavioral adaptation
Emotional experiences often evoke neural plasticity that supports adaptive changes in behavior, including maladaptive plasticity associated with mood and substance use disorders. These adaptations are...
https://www.science.org/doi/10.1126/science.adp1562#core-collateral-share
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Check out our commentary on Mitra et al.'s findings in Biological Psychiatry on an epigenetic mechanism promoting heroine relapse after prolonged abstinence
www.sciencedirect.com/science/arti...
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An Epigenetic Mechanism Promoting Heroin Relapse After Prolonged Abstinence
https://www.sciencedirect.com/science/article/pii/S0006322324018213
9 months ago
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I owe it all to Lebanon ❤️
add a skeleton here at some point
11 months ago
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reposted by
RoseMarie Akiki
Science Magazine
12 months ago
Noncoding RNA controls the expression of a gene implicated in drug- and stress-induced behaviors. Learn more in a new
#SciencePerspective
:
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A neuronal gene that loops the loop
Noncoding RNA controls the expression of a gene implicated in drug- and stress-induced behaviors
https://scim.ag/4gOQbzD
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It's like someone read my mind!
add a skeleton here at some point
about 1 year ago
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reposted by
RoseMarie Akiki
Science X / Phys.org
about 1 year ago
A genetic regulatory mechanism involving RNA:DNA structures plays a crucial role in behavioral adaptations to emotional experiences, potentially informing RNA-based therapies for psychiatric disorders.
doi.org/g8vf5f
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RNA:DNA 'sandwich' plays key role in behavioral adaptations arising from emotional experiences, research reveals
A team of neuroscience researchers at the Medical University of South Carolina reports in Science the discovery of a new genetic regulatory mechanism involved in behavioral adaptations to emotional experiences in a preclinical model.
https://medicalxpress.com/news/2024-12-rnadna-sandwich-plays-key-role.html?utm_source=bsky.app&utm_medium=social&utm_campaign=v2
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reposted by
RoseMarie Akiki
Timothy Bredy
about 1 year ago
Following
@daylab.bsky.social
’s nice paper on eRNA regulating Fos, and then our paper showing eRNA mediated regulation of NR4A2, here’s yet another eRNA controlling NPAS4. LncRNAs for the win in the brain!
www.science.org/doi/10.1126/...
loading . . .
A long noncoding eRNA forms R-loops to shape emotional experience–induced behavioral adaptation
Emotional experiences often evoke neural plasticity that supports adaptive changes in behavior, including maladaptive plasticity associated with mood and substance use disorders. These adaptations are...
https://www.science.org/doi/10.1126/science.adp1562
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Great perspective on our paper by Dr. Heller looping our findings to modern molecular neuroscience!
add a skeleton here at some point
about 1 year ago
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you reached the end!!
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