Marta Barisa
@marta-barisa.bsky.social
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Solid tumour immunotherapy @ UCL Great Ormond Street Hospital for Children, London, UK
reposted by
Marta Barisa
Chris Tape
about 2 months ago
Excited to share our new paper: ‘Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell–Mediated Immunomodulation’ led by Callum Nattress in collab. with Jonathan Fisher lab (1/13)
aacrjournals.org/cancerres/ar...
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Marta Barisa
Science Magazine
about 2 months ago
This year’s
#NobelPrize
in Physiology or Medicine has been awarded to three scientists for discovering how the immune system distinguishes friend from foe.
https://scim.ag/3Wt5rdi
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Medicine Nobel goes to three researchers who identified immune system’s security guards
Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi discovered regulatory T cells that prevent autoimmune disease
https://scim.ag/3Wt5rdi
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reposted by
Marta Barisa
Cancer Research UK City of London Centre
2 months ago
🏆Announcing our Development Fund 2025 Awardees 🏆 This pump-priming fund enables researchers to explore and launch innovative new ideas. Swipe to see our first four successful applicants and read about all the projects and co-applicants on our website:
www.colcc.ac.uk/development-...
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reposted by
Marta Barisa
Waggoner Lab
4 months ago
Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for antigen-dim cell targeting & avoidance of antigen-dim tumor relapse
@natcomms.nature.com
www.nature.com/articles/s41...
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👩🔬 Check out the stunning AI-analysed videos of aB7H3 CAR-T killing clumps of patient-derived neuroblastoma generated by our colleagues Prinses Maxima 🔬 CD4 CAR (blue), CD8 CAR (green), live tumours (yellow), dead tumours (red) Full story
nature.com/articles/s41...
@natureportfolio.nature.com
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4 months ago
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🚨 Avidity of clinical-stage aB7H3 scFv CAR-T's predicts function 🚨 The conclusions took us by surprise, in the opposite direction of canonically held knowledge about CD19- CARs in leukaemia Check out our latest story in
@natureportfolio.nature.com
www.nature.com/articles/s41...
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Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function - Nature Communications
CAR-T cells have been found to be less effective as treatment for solid tumours. Here the authors, utilising B7H3 as an antigen, consider how changes in B7H3 binders lead to functional changes of CAR-...
https://www.nature.com/articles/s41467-025-61427-4
4 months ago
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🌟 I’ve written a children’s book about vaccines- probably the greatest ever paediatric health innovation. I struggled to find resources to explain this to my son that were accessible to him, so I wrote my own. Everyone is welcome to our story time! 🔬 You can find the book here:
amzn.eu/d/3QNB5Xh
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7 months ago
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🚨🔬 Happy to share our review out in Nat Biotech Great collab on Mϕ, γδT and NK cell translational success (and fails) with colleagues from Harvard&Zhejiang. What can we learn from innate immune tx trials, how can we do better and what next for the field?
www.nature.com/articles/s41587-025-02629-5
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Engineering innate immune cells for cancer immunotherapy - Nature Biotechnology
The unique attributes of innate immune cells position them as attractive candidates for cancer immunotherapy, with engineering strategies to enhance their antitumor potential, offering notable therape...
https://www.nature.com/articles/s41587-025-02629-5
8 months ago
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