Jyotirmoy Dey (@jyotirmoydey.bsky.social)

Direct Pd-Catalyzed β-C(sp3)–H Hydroxylation of Aliphatic Carboxylic Acids β-Hydroxy carbonyl scaffolds are of paramount importance due to their presence in a variety of natural products and bioactive molecules. In this study, we present a direct palladium-catalyzed β-C(sp3)–H hydroxylation of aliphatic carboxylic acids. The reported method employs convenient and readily available TBHP as an oxidant and provides an efficient, one-step route to a diverse range of β-hydroxy acids. Key aspects include the compatibility of this method with challenging α-non-quaternary carboxylic acids as substrates and excellent functional group tolerance. This newly developed method is expected to prove useful for generating compound libraries relevant to multiple disciplines. https://pubs.acs.org/doi/10.1021/acs.orglett.5c00614