Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

Goldschmidt's hopeful monsters in cancer: single cell DNAseq shows whole genome doubling (WGD) is an ongoing and frequent mutational process in ovarian cancer. www.nature.com/articles/s41... beautiful work from @sohrabshah.bsky.social and team

Whole-genome doubling (WGD) occurs in ~30% of solid tumors and is linked to poor outcomes. Is it a one-time event or an ongoing mutational process? In our new @nature.com paper now in print, we show WGD continuously shapes tumor evolution and immune evasion. www.nature.com/articles/s41...

We have two #postdoc positions open to join my team at @ebi.embl.org in beautiful Cambridge! We are a mission-driven, highly collaborative and dynamic team located at the Wellcome Genome Campus, one of the most exciting hubs in the world focused on biomedical research 👇

The stomach is an organ unique in its function, environment and exposures. How does this affect the mutations that normal cells in the stomach acquire? What does this reveal about the origins of stomach cancer? These questions and more in our @nature.com paper: www.nature.com/articles/s41...

New year, new beginnings! I am absolutely delighted to share that I have joined Harvard Medical School, Massachusetts General Hospital and Broad Institute to start my research group in Boston in January 2025! 🎉🧬🔬 #NewPI #AcademicSky #NextChapter (1/7)

It was a treat to see the @OnesandToozePod live in New York last night. Timely dialogues on climate activism, the UN and cosmopolitanism. And Keynes, of course!

Excited to share a commentary on emerging challenges in understanding and targeting cancer genome instability to improve patient outcomes: https://bit.ly/3XoSstk Thanks to @CD_AACR for the opportunity and to everyone else from the @AACR NextGen Stars Program who contributed!

We are only one month away from the @GordonConf GRC+GRS in Single-Cell Cancer Biology! We have a fantastic program lined up! A few spots left. Register now! 🔥 GRS: June 8-9 (early career)🔥 https://dir.lat/O0TlRc 🔥 GRC: June 9-14 (main...

Beautiful morning in San Diego! I am excited to present our latest work on genome instability in ovarian cancer. Looking forward to a fantastic session with @sajraparicio @McclellandLab @skimomiks (12:15-14:00 PT, Room 29 Conv...

In Orlando this week for #AACR23! A great experience thus far presenting our recent work, meeting colleagues and hearing about the latest advances.

To close out the year, I am incredibly delighted to share our latest work now published in @Nature. We studied the impact of genomic instability on the tumor microenvironment and its role driving immune evasion in ovarian...

What an epic final full of so much suspense! Congratulations, Argentina! #FIFAWorldCup

Fabulous time with colleagues from across all the #CancerGrandChallenges teams in beautiful Barcelona.

Wonderful morning meeting the Queen of Spain and Spanish colleagues in NYC to discuss the future of cancer research. Thanks to @ContraCancerEs @CasaReal @IC_NewYork @comunidadECUSA for hosting this event. #WorldCancerResearchDay

It is great to be back at @CSHL for the Biology of Genomes "Reunion Tour 2022" 🤘. Come say hi if you are here! #BoG22

#AACR22 minisymposium on single-cell and spatial profiling of tumor cells and the immune microenvironment, chaired by @IamLinghua and @SohrabShah https://ativsoftware.com/appinfo.php?page=Session&project=AACR22&server=eventpilotadmin.com&id=P21441#AACR22#AACR22AACR22

Great @CompOncMSK representation at the #AACR22 poster session this morning!

Thrilled to be in New Orleans for #AACR2022! A great return to in-person conferences after two years.

Proud and delighted to share our latest work on the impact of mutational processes on immune and malignant phenotypes in ovarian cancer. https://www.biorxiv.org/content/10.1101/2021.08.24.454519v1 @sloan_kettering @CompOncMSK @SohrabShah @DmitriyZamarin @fuhlitz #singlecell...

Francisco Goya’s enlightened genius on display at The Met’s “Graphic Imagination”. #metmuseum #Goya275

Vigil for the victims of police brutality. #BlackLivesMatter

This weekend I will be riding with Team @CompOncMSK at @Cycle4Survival. Every donation helps! All the funds raised will support rare cancer research at @sloan_kettering. You can donate here: https://bit.ly/2vqfnM6

Superb work being presented today at the @sloan_kettering CMO Symposium. Come by the poster session to hear about the latest work we are doing between the @SohrabShah Lab and an incredible cross-disciplinary team of collaborators at MSK – 2:50-3:30pm at Zuckerman Research Center.