Fresh from the oven! Ever wondered how cells keep ATR activation controlled during normal DNA replication? Our last paper in @natcomms.nature.com shows that they do it by extracting POLA/PRIM from chromatin using VCP/p97! Still curious? Take a look...🧵🧵🧬🧬

Very proud of the work of @rodrimartinr.bsky.social, Sara Rodríguez Acebes and the rest of the team. This has been a long effort with many people involved over the years. We have now a better understanding on how VCP/p97 connects priming during DNA replication and the replication stress response.