How immuniry change wuth age - age-dependent TH2 bias in CD4 T cells and CD8 T cells is broadly driven by reduction in T cell signalling strength over time www.nature.com/articles/s41...

Grateful to our amazing @CleClinic_PHO team for shining so brightly at #LightTheNight 🌟 Your passion and advocacy bring hope to leukemia & lymphoma patients and families every day. Together, we’re lighting the path toward a cure. ❤️🕯️ #LLS #TeamClevelandClinic @bloodcancerunited.bsky.social

You want to feel good and 🤩👏… come to @velosano . Nothing feels as good as being with previous #ChildhoodCancer patients who are now #Survivors and #riding for the #Cure

Here we go ; safe ride to all #Riders @bikeVeloSano 25 miles. 🙏thank you so much for all you do to raise $ for #CancerResearch at @ClevelandClinic 💯 for the #Cure . Cancer impact goes beyond one patient , one family … it affects the community and together 💪 can make an impact

The impact of CMV reactivation on mortality after chimeric antigen receptor T-cell therapy url: ashpublications.org/bloodadvance...

Join us on July 26 at the Cleveland Metroparks Zoo for a one-of-a-kind bike ride for kids ages 3–10 to raise funds for pediatric #cancer #research at @clevelandclinic.bsky.social . www.velosano.org/trike-bike www.velosano.org/trike-bike/

This is sad news abd huge loss to #Medicine #Pediatric and #Science in general . May his menory be a blessing . pioneerpressobits.space/atul-butte-s...

Mentorship is a powerful way to give back in #PedsHemOnc. I am so honored to be among #mentors at the American society of pediatric hematology - oncology speedy mentorship supporting the next generation boosts career satisfaction, fosters personal growth & strengthens our field for the future.

Dr. Caitlyn Duffy from @stjude.bsky.social presented great talk at poem_group about Implementation science in leukemia 1- discussed the 17 year odessy - translation of discovery to delivery 2- EPIS implementation framework

So grateful to be invited to #POEM 4th Scientific Conference! Connecting with ped oncologists to improve care & access for kids with cancer has been truly inspiring. 👏🎉 Dr. rawad rihani and Dr. Gevory Tamamyan for fantastic reception to start #POEM2025 #PediatricOncology #CancerCare

A heartfelt thank you to our incredible team at Cleveland Clinic Children’s for coming together in support of St. Baldrick’s Foundation. Your dedication, generosity, and passion for making a difference in the lives of children with cancer is truly inspiring #StBaldricks m.youtube.com/watch?v=azNy...

Thank you 👏 Dr. Jim Fernandez for organising great conference #PrimaryImmunodeficiency at @ClevelandClinic and great talk about #IVIG . It is amazing to see the use increase significantly. Did you know it takes 8-9 months to make IVIG and it approximately collected from 15,000 donors

Great advice by Troy Torgerson about what to do when you have VUS “variable unknown significance “ at @clevelandclinic.bsky.social #PrimaryImmuneDeficiency symposium

Still time to join us at #UodateInPrimaryImmunodeficiency at @clevelandclinic.bsky.social endorsed by immune deficiency foundation Very educational agenda and world renowned experts discussing diagnosis and management of different immune deficiencies www.clevelandclinicmeded.com/live/courses...

Celebrating a Second Chance at Life Symposium May 3 - 9, 2025 A week packed full of information, inspiration and community. symposium.bmtinfonet.org

The fight against # ChildhhodCancer is not just medical challenge - it is calling - beyond medication to wholistic care So proud of our music therapist 🎉👏 Emily Ervin @CleClinicKids for supporting kids - see picture below 👇 with one of our kids cutting her hair

So proud and inspired by our team : Preston , Katie and Stacey participating in @clevelandclinic.bsky.social #StBaldrick shave for the cure event We are doing what we do to support kids & their families and organisations like St Baldrick so we can do research to find more cure and better therapies

So excited to welcome our #Pediatric residents at @clevelandclinic.bsky.social To join all our care givers in our mission “Caring for life, researching for health, educating those who serve”

Childhood cancer survivors have a more than two-fold increased risk of developing melanoma during their lifetime, compared to the general population, as well as a two-fold increased risk of death associated with a melanoma diagnosis consultqd.clevelandclinic.org/study-reveal...

fotoshare.co/i/20j6sp6 so excited to celebrate the grand finale of #LLS

The Pediatric Rare Disease Priority Review Voucher Program, incentivizing research peds rare diseases expired Dec/2025. Research for #ChildhoodCancer is affected . ask Congress to reauthorize the program by supporting the Give Kids a Chance Act of 2025 (H.R. 1262) www.votervoice.net/mobile/Bioco...

so honored to be part of the team led by Dr. Adetola kassim #BMTCTN CTN1507 Haplo-HCT for patients with severe sickle cell disease; - Of 42 Adult pts underwent haplo-HCT: 95% alive at 2 yrs, 88% are potentially cured at fraction of the cost of gene therapy evidence.nejm.org/doi/pdf/10.1...

Great job 👏 👏 by Dr. Mark Walters @uscfb.bsky.social to present RUBY study sponsored @editasmed -Gene therapy for #SCD - sustained normal hemoglobin and hgb F above >40% - F cells >>99.3% - pain free in 27/28 patients - improved QOL

Watch this incredible story and then ask me why i chose to be pediatric oncologist- A fight for survival 💪 These kids are inspiration Our team of clinician and scientists working on #Tumor Vaccine for Ewing Sarcoma www.wkyc.com/article/news... www.wkyc.com/article/news...

2024 was an incredible year of innovation for our Division of Pediatric Hematology & Oncology! We’re proud to share some of our key accomplishments from the past year: www.linkedin.com/posts/clevel...

I enjoyed listening to tbe new @clevelandclinic.bsky.social podcast about pediatric health related topics “Little health” open.spotify.com/episode/2uKa...

Cord blood transplant was associated with less risk of relapse in MRD positive AML getting MAC regimen HCT. www.nature.com/articles/s41...

AR Marderstein et al showed increased mitochondrial mass & oxidative stress in #Downsyndrome led to mutations in regulatory regions genes in HSCs which explain increased #Leukemia in DS Single-cell multi-omics of human fetal blood in #Down Syndrome @nature.com www.nature.com/articles/s41...

Transplant-Free Strategies for Low-Risk Relapsed Hodgkin Lymphoma offer excellent cure and should be considered for selected patients to avoid long term side effects of high dose chemo / autologous transplant www.medpagetoday.com/hematologyon...

Thrilled to be again in Kuwait and excited to hear about #PedBMT program growth presented by Dr Sondus Alsharidah at the 4th Kuwait 🇰🇼 Ped BMT & Gene therapy conference. 👏🎉 work. BMT is not quick surgery and rather a long journey and best care is local where patients families can be supported

Thank yoh @vjhemonc.bsky.social for highlighting advances and barriers to make gene therapy for SCD more accessible www.vjhemonc.com/video/odfje4...

Children with ETV6::RUNX1 or high-hyperdiploid B-ALL have excellent 5-year EFS (97.7% and 94.7%) with low-intensity therapy. However, high-hyperdiploid B-ALL with slow MRD response needs improved treatments 👇👇👇 ashpublications.org/blood/articl...

excited to share our commentary review @jama oncology for Jon-BMT option in relapsed Hodgkin lymphoma . Nontransplant Treatment for Relapsed Pediatric Hodgkin Lymphoma—Less Is More jamanetwork.com/journals/jam...

What a fantastic late breaking abstract fantastic by Françoise Bernaudin ⁦‪@ASH_hematology‬⁩ #ASH24: long term outcomes in DREPAGREFFE study evaluating all-HSCT in # SCD with abnormal cerebral velocity. - alloSCT provided better primary prevention of stroke, ⬆️social QoL, working memory

It was a special connection the moment Katie met the woman who donated a portion of her liver and gave her son, Sonny, a new life. “Sandy gave a piece of herself to save my baby’s life. Organ donation is truly an unconditional gift.” More: cle.clinic/3O66NXk

Fascinating findings from the @cmullighan.bsky.social team: ctDNA was identified in all cases of hematological malignancies, in 19 out of 38 patients with solid tumors, and in just 1 out of 18 brain tumor patients 👇👇👇 www.nature.com/articles/s41...

Congratulations 👏🎉 Dr John Tisdale for receiving well deserved recognitions and The Ernest Beutler Lecture award #ASH24 @ash-hematology.bsky.social His work on #GeneTherapy and #BMT IN #SCD opened the path for many treatments and saved so many lives .

congratulations 👏🎉 to Dr. Sean Morrison who received this year @ash-hematology.bsky.social #ASH24 E. Donnall Thomas lecture award for his work on hematopoietic stem cell biology. Interesting work on importance of BM niche #BMT interesting work on impact of B blockers on engraftment

Fred Hutch at #ASH24: Hematologist-oncologist Dr. Natalie Wuliji presents findings from a multi-center study showing how socioeconomic status affects access to allogeneic hematopoietic cell transplantation for adults with acute myeloid leukemia #AML. ash.confex.com/ash/2024/web...

Congrats to a giant in our field, Dr. Eliane Gluckman who worked with Dr. Hal E. Broxmeyer. #CordBlood transplant wouldn't exist w/o their collaboration. When I visited @IU_Health a few years ago he showed me equipment they used for 1st patient #ASH24 #bmtsm

Sen Zhan , PhD presented data at #ASH24 plenary session- PF4 impact on murine and human HSC aging . This could provide targeted therapies for HSC rejuvenation and potential strategies improve the course of age-related immune dysfunction and hematopoietic diseases #aging #HSC

Two more points made by Dr. Rau #ASH24 1- despite that Blina has not been tested in Adolescents /HR-ALL but we could probably extrapolate that Blina could also decrease Relapse risk 2- increased risk of grade 3+ infections beyond cycles of Blina #ChildhoodCancer cure more Pts , and to cure better

I never tire of seeing these progressively improved pediatric ALL survival curves, which represent one of the most remarkable achievements in all of medicine. Amazing to see even more improvement with bispecific antibody #immunotherapy presented in the #ASH24 Plenary session. #hematology #leukemia

Dr. Rachel Rau presented Children Oncology Group study ALL1731 study at plenary session #ASH24 👏👏 1- Blina decreased BM relapse significantly across all risk factors including ; hypodyploid , +MRD , Latino ethnicity, etc 2- no change in CNS relapse #ChildhoodCancer #Leukemia

Congratulations 🎉and very well deserved to Dr. Elaine Gluckman for receiving #ASH24 WALLACE H. COULTER AWARD - life time achievement in Hematology . She pioneered cord blood transplantation and made great advances in care of non-malignant blood disorder patients

Update fromBbluebird bio HGB-206 group C and HG -210 study regarding Lovo-cel for #SCD at #ASH24. - Data about 58 patients - 86.8% achieved complete resolution of all VOE - 94.7% had complete reduction of severe VOE - Model to predict likelihood of VOE-CR and sVOE-CR at 6 months

Impressive results about Exa-Cel in TDT from @vertexpharma.bsky.social at #ASH24 - 54 patients - 98% (53/54) had achieved Transfusion free x12 months - the remaining patient is free of RBC Tx for at least 8 months Similar results about safety and efficacy in #SCD

BEACON study initial data @beamforall.bsky.social IN #AS24 - BASE editing in Hgb1/2 for #SCD :7 patients - less collection cycles - faster engraftment in ANC (17 days) and PLT (19 days) - one death - high level of hgb F (>60%) with improvement in total hemoglobin and less hemolysis