Big thanks to @tododge.bsky.social and @mollyschumer.bsky.social for their invaluable mentorship!! I’ll also be presenting a poster on this work at PEQG this Thursday (8:30-10pm, PgmNr 284T)

Exciting new work from the lab led by @lagiven.bsky.social & co-advised by @tododge.bsky.social mapping pigmentation variation in the swordtail X. nezahualcoyotl! Spotting variation is linked to xmrk but embedded in complex genomic regions that Tris & Lyle tackled with UL nanopore: shorturl.at/Ljw1z

Excited to share new work on two sex-linked pigment traits in Xiphophorus! This project was led by undergrad @lagiven.bsky.social, who’s worked with me for the last 3(!) years. www.biorxiv.org/content/10.6...

We are excited to share our pan-pangenome paper! This is a long time coming work of my postdoc with the incredible @psudmant.bsky.social, and a stellar group of people! I hope you enjoy reading it! And I am excited to talk more more about it this week at #PEQG26!! www.biorxiv.org/content/10.6...

We are often asked whether pangenomes are worth the hassle. The files can be large and methods to explore them are much more challenging than linear references. Earlier this week, we preprinted a clear example of how and why pan-genome graphs are so important for trait discovery.

Thrilled to present my dissertation research at the Hamilton Symposium! We used approaches including GWAS, long-read sequencing, phylogenetic methods, and behavior experiments to uncover the genetic basis and evolutionary history of a shared polymorphism. Can’t wait to share what we’ve learned!

Thrilled that our new review article on animal hybridization is now up on EcoEvoRxiv! 🎉 Working on this review with @mollyschumer.bsky.social was a blast, and it was such a wonderful opportunity to catch up on all the amazing work in animal hybridization over the last few years!

Ver excited to share my just-published Darwin Review with @lh3lh3.bsky.social on population-scale long-read sequencing! royalsocietypublishing.org/rspb/article...

Happy to announce the alpha release of the SCINKD3! SCINKD3 is an extension of SCINKD streamlines the use of WGS data from multiple individuals to identify sex chromosomes. In testing, its shown to be robust in many cases with as few as 4 individuals. github.com/DrPintoThe2n...

Long reads carry multiple small vars and SVs and their phasing. LongcallD is the only caller that tightly integrates germline/mosaic small/structural vars/MEIs and their phasing in a single C program. One command line to get competitive small variant calls and better SVs. Led by Yan Gao.

Excited so share our newest study using a single-library HiFi-CiFi approach to generate chromosome-scale diploid assemblies of two vole genomes, identifying putative drivers of divergent pair-bonding behavior, namely a prairie-vole-specific duplication of Avpr1a gene, led by @mabuelanin.bsky.social

Proud that this work is now published! We hope it helps orient future #Nanopore long-read sequencing studies hunting for structural variants Also really happy to share eight new high-coverage (>100x) long-read read pools and assemblies with the #Drosophila community! doi.org/10.1093/g3jo...

I am hiring a staff bioinformatician for my new lab at the University of Utah! Please consider applying if you are on the hunt: employment.utah.edu/salt-lake-ci...

Excited to join PAG this year! Tomorrow (01/11) I will be sharing my work on black-footed cat genomics! Stop by the "Wildlife Genomics" session @ 8:55 am in Pacific F-G to learn about Africa's smallest cat

I'll be presenting my work tomorrow morning at #PAG33! Stop by Pacific C (Comparative Genomics - Animals) @9:16am to learn about structural variation of swordtail Y-chromosomes and alternative reproductive tactics.

Excited to present at #PAG33 on the dynamic evolution of a balanced polymorphism. We've uncovered unexpected patterns using long-read sequencing and other fun methods. Talk: Saturday @8:40am in Pacific C (Comparative Genomics - Animals) Poster: Monday @10-11:30am in Golden State Ballroom (P216)

Absolutely thrilled to share the latest work from my lab focused on the variation and evolution of human centromeres among global populations! We assembled 2,110 human centromeres, identifying 226 new major haplotypes and 1,870 α-satellite HOR variants. www.biorxiv.org/content/10.6...

Modestly, we decided to review a century's worth of theories of balancing selection :) onlinelibrary.wiley.com/doi/10.1111/...

Beautiful work by @nadiahaghani.bsky.social and @mollyschumer.bsky.social on perhaps the most charismatic coloration trait in swordtails and platys!

Happy to share work spearheaded by former grad student Colin Shew testing shared duplicated cis regulatory elements (CREs) using an MPRA. While we find some high effect CREs, collectively paralog differences represent modest effects accounting for observed gene expression divergence.

Do you know ~60% of human SVs fall in ~1% of GRCh38? See our new preprint: arxiv.org/abs/2509.23057 and the companion blog post on how we started this project and longdust: lh3.github.io/2025/09/29/o.... Work with Alvin Qin

First pop gen paper from our lab! We find repeated evolutionary turn over of sex chromosomes in darters contributes to reproductive isolation. Turnover may be an escape hatch to resolve mitonuclear conflict & neo sex chromosomes evolved via a rare recessive mutation. www.biorxiv.org/content/10.1...

The Sudmant lab at UC Berkeley is seeking a postdoc to work on a fully funded NIH project to understand differences in DNA repair and somatic mutation across the primate tree of life. Please spread widely to those who may be interested aprecruit.berkeley.edu/JPF05052

If you're attending #SMBE2025 check out graduate student @tododge.bsky.social 's talk at 11:30 am tomorrow (8:30 pacific time tonight if you're watching remotely). It's a wild ride with lots of complex structural variation, balancing selection, and introgression!

Excited to talk about balancing selection, hybridization, and independent evolution at the #SMBE2025 hybridization & introgression symposium! Symposium 14: Day 3, Room 2 @ 11:30am Beijing Time

🚨Preprint🚨 Sex chromosome identification & genome curation from a single individual with SCINKD www.biorxiv.org/content/10.1... Incredible work led by @drpintothe2nd.bsky.social in collaboration w/ @drsimonegable.bsky.social @stuartvnielsen.bsky.social @tonygamble.bsky.social SE Keating & CH Smith

Please share with early career researchers interested in pursuing a PhD! Our goal is to make the application process more transparent with info sessions and 1:1 mentorship.

📣📣📣 So pleased to see @vdbijl.bsky.social's stunning analysis of the inheritance and genetics of guppy color diversity out today @natecoevo.nature.com! Deep learning reveals the complex genetic architecture of male guppy colouration. www.nature.com/articles/s41...

1/9 Excited to share the preprint for the second half of my PhD with @mollyschumer.bsky.social: Connecting human environmental impacts to hybridization in swordtail fish through genomics, GIS, water chemistry, and histology. Thread below! #SciSky www.biorxiv.org/content/10.1...

Already seeing big improvements by combining PacBio and ONT Ultralong reads!

Awesome new paper by @lucalivraghi.bsky.social et al. doi.org/10.1016/j.cu... in @currentbiology.bsky.social on the evo-devo of a butterfly color variation enjoy the show!

A project five years in the making, we've now published complete "T2T" genomes for six additional ape species! It turns out that finishing (and analyzing) six genomes is slightly more work than one... doi.org/10.1038/s415...

Call for Papers! Special Issue: Functional and Adaptive Effects of Genomic Structural Variation in @heredityjournal.bsky.social 📅 Submission Deadline Extended: 1st April 2025 Guest Editors: @ellenleffler.bsky.social, @mydennis.bsky.social, Omer Gokcumen, and myself www.nature.com/collections/...

New NIH funded research from our group now out. We are interested in development and evolution of cell types and adult phenotypes. In this paper, postdoc Dylan Huang and collaborators asked how a pigmentary ornament of bright white cells develops on the fin of zebrafish. www.pnas.org/doi/10.1073/...

Finally ready to see the world! Theories of balancing selection - past, present and future: www.biorxiv.org/content/10.1... A true collaborative effort that brought together theoreticians and empiricists, models, data, and fresh perspectives on how balancing selection can shape genetic variation.

Rising temperatures are not slowing #mosquitoes down... A new study coauthored by Stanford's Lisa Couper and @stanfordwoods.bsky.social Erin Mordecai finds that mosquitoes -- and the diseases they carry -- can adapt to hotter temperatures. Read the study: bit.ly/3PqTNw8

Congrats to @jeffgroh.bsky.social et al on publication of "Ancient structural variants control sex-specific flowering time morphs in walnuts and hickories" www.science.org/doi/10.1126/...

Moved here recently and figured I should shamelessly promote our recent paper for my very first post.