Wiltgenlab
@wiltgenlab.bsky.social
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Professor at UC Davis. Interested in neurobiological mechanisms of learning and memory.
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Wiltgenlab
Denise J. Cai, Ph.D.
6 days ago
How does neuronal gene expression evolve over time in response to experience? CytoTape will help us find out - a major milestone for neuroscience, providing new ways to study memory & aging š§ Congrats to the whole team! Looking forward to our continued collaboration on this work š
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Dr. Keith R. Brunt
28 days ago
Epstein-Barr Virus
#EBV
was linked to
#MultipleSclerosis
- now a plausible cause has been found, misidentification by longterm memory T-cells that pick on the wrong protein, ANO2, instead of the EBV-antigen. Massive inflection towards the elimination of MS!!! š§Ŗš§ Cell
www.cell.com/cell/fulltex...
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Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis
Researchers identified anoctamin-2 (ANO2) as a frequent autoimmune target in multiple sclerosis, with T cell responses against ANO2 occurring in over half of patients. These ANO2-specific T cells shar...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2901481-3
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Roddy Grieves
about 1 month ago
Can humans & animals really use internal maps to take shortcuts? Tolman famously said yes - based largely on his Sunburst maze. Our new review & meta-analysis suggests evidence is far weaker than you might think. š§µš
doi.org/10.1111/ejn....
@uofgpsychneuro.bsky.social
@ejneuroscience.bsky.social
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Tolman's Sunburst Maze 80āYears on: A MetaāAnalysis Reveals Poor Replicability and Little Evidence for Shortcutting
In 1946, Tolman etĀ al. reported that rats could take a novel shortcut to a goal after training on an indirect route, supporting the Cognitive Map theory. However, a review of subsequent Sunburst maze...
https://doi.org/10.1111/ejn.70365
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about 1 month ago
What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality.
www.biorxiv.org/content/10.6...
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Jonathan Eisen
about 2 months ago
Reminder - a great job opportunity at
@ucdavis.bsky.social
Dean, College of Biological Sciences
jobs.sciencecareers.org/job/676649/d...
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Dean, College of Biological Sciences - Davis job with University of California, Davis | 676649
University of California, Davis Dean, College of Biological Sciences The University of California, Davis (UC Davis) seeks a dynamic, effective, and
https://jobs.sciencecareers.org/job/676649/dean-college-of-biological-sciences
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Earl K. Miller
about 2 months ago
A must-read review. It argues that brain areas are only one of several organizing principles and are not especially central, given their weak correspondence to function. Cytoarchitecture and connectivity are a starting point, not the endpoint.
www.nature.com/articles/s41...
#neuroscience
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Rethinking the centrality of brain areas in understanding functional organization - Nature Neuroscience
Parcellation of the cortex into functionally modular brain areas is foundational to neuroscience. Here, Hayden, Heilbronner and Yoo question the central status of brain areas in neuroscience from the ...
https://www.nature.com/articles/s41593-025-02166-z
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Nicola Sambuco
2 months ago
This new preprint by
@katewassum.bsky.social
is š„ Really solid work. It's a must read
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Keri Martinowich
2 months ago
This new ERC study uses an overlapping set of human š§ donors as our just dropped locus coeruleus preprint. Availability of data from both regions in the same donor facilitates our current efforts to analyze molecular signaling across the circuit, which is highly vulnerable in Alzheimer's disease.
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Ben Hayden
2 months ago
Thoughtful review with some good recent historical perspective on the ongoing paradigm shift that is radically changing the way we think about what brain areas do.
www.nature.com/articles/s41...
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How distributed is the brain-wide network that is recruited for cognition? - Nature Reviews Neuroscience
Both localized and distributed views on the functional organization of the brain have been put forward. In this Perspective, Rosen and Freedman examine the degree to which these two views account for ...
https://www.nature.com/articles/s41583-025-00992-5
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Mark James Adams
3 months ago
One for the heredity scolds: construct a multi-tissue GRM where people are differentially related to themselves.
www.nature.com/articles/d41...
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We are all mosaics: vast genetic diversity found between cells in a single person
Technical advances allow researchers to trace the genetic changes that occur over time.
https://www.nature.com/articles/d41586-025-03768-0
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Amy Nemmity
3 months ago
I don't see a lot of people talking about this, so I want to highlight something GOOD Billie Eilish stood in a room full of billionaires and said "you're billionaires... Why?" She donated 11.5 MILLION DOLLARS to food equity and climate orgs, which Stephen Colbert announced to said billionaires.
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Billie Eilish Calls on Billionaires to Support People in Need: 'No Hate, But Give Your Money Away'
Billie Eilish donates $11.5 million from 'Hit Me Hard and Soft' tour to charity and calls on billionaires to support people in need during hard times.
https://www.rollingstone.com/music/music-news/billie-eilish-charity-donation-billionaire-call-out-1235456868/
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SJo
3 months ago
Excited to share the latest from the lab on the molecular mechanisms of silencing and un-silencing a hippocampal engram ensemble. Was fun using a variant of the EPSILON technique developed by Adam Cohen's lab. (1/2)
www.sciencedirect.com/science/arti...
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Molecular mechanisms mediating engram ensemble retrievability state in mice
Engrams, ensembles of neurons that store memories, exist along a continuum of retrievability. Normally, sensory cues can reactivate a latent engram toā¦
https://www.sciencedirect.com/science/article/pii/S0896627325007536?dgcid=author
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Paul Frankland
4 months ago
New paper from the lab šØ Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...
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https://authors.elsevier.com/a/1lzT-3BtfHC-Pj
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Shaked Palgi
4 months ago
I am excited to share my PhD work on head-direction cells recorded in the wild, now published in
@science.org
, where we recorded neurons in bats flying outdoors on an island.
doi.org/10.1126/sci...
With
@ray-neuro.bsky.social
, Shir Maimon, Liora Las, Nachum Ulanovsky and many others
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Very interesting work by the Yin lab! š¤
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4 months ago
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Stephanie L. Grella, PhD
4 months ago
How prediction error drives memory updating: role of locus coeruleusāhippocampal interactions: Trends in Neurosciences
www.cell.com/trends/neuro...
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How prediction error drives memory updating: role of locus coeruleusāhippocampal interactions
The brain constantly generates predictions based on oneās knowledge of the world, as captured in memory. When these predictions are in error, our knowledge base must be revised to remain relevant. Her...
https://www.cell.com/trends/neurosciences/fulltext/S0166-2236%2825%2900189-4
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Paul Frankland
4 months ago
New paper from the lab led by Ali Golbabaei. If youāre interested in systems consolidation, generalization and hippocampal neurogenesis a short š§µ follows:
authors.elsevier.com/a/1lsO73QW8S...
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https://authors.elsevier.com/a/1lsO73QW8SA4Gf
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May-Britt Moser
5 months ago
So proudš¤©: Beautiful work by
@clykken.bsky.social
šš» et al: finally we understand how the hippocampus can express multiple maps even though grid cell inputs are universal metrics. E.g. hippocampal global remapping was induced when different grid modules anchored independently to environments. See šš½
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Zoe Drayson
5 months ago
When a typo in your Google search leads to new and exciting philosophical positions
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Emilie MacƩ
5 months ago
Thrilled to share that our work is now published in Science! ⨠We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! š§
www.science.org/doi/10.1126/...
š§µ1/
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Tyler Norris
5 months ago
MLK Jr. on violence:
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Hugo Spiers
5 months ago
Mice are always smarter that we expect, here guessing the trail ahead rather than just blind following. Cool work:
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Jake Wintermute
6 months ago
When the PI hasn't worked in at the bench in years but needs to do something in the lab for a photoshoot
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Green Day at Bottlerock 2025 š¤
9 months ago
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Josh Johansen
9 months ago
Iām excited to share a new paper from the lab. The study led by Xiaowei Gu reveals how the mPFC encodes complex emotional memories, using an internal model to infer emotional associations and memories via projections to the amygdala. aš§µ(1/8)
rdcu.be/el19t
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Prefrontal encoding of an internal model for emotional inference
Nature - Neurons in the rodent dorsomedial prefrontal cortex encode a flexible internal model of emotion by linking directly experienced and inferred associations with aversive experiences.
https://rdcu.be/el19t
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Paul Frankland
9 months ago
Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.
rdcu.be/el18q
A short thread follows for those interested. 1/n
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Systems consolidation reorganizes hippocampal engram circuitry
Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...
https://rdcu.be/el18q
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Danai Riga
9 months ago
A wonderful day for science, to see the (peri)
#LC
in all its glory. A ginormous effort from all involved, and a fantastic resource for the field. Chapeau š© š§ šµ
www.nature.com/articles/s41...
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Heterogeneous pericoerulear neurons tune arousal and exploratory behaviours - Nature
A set of neurons in the peri-locus coeruleus region controls arousal and avoidance states, providing an understanding of the neurobiological basis of arousal and exploratory behaviours.
https://www.nature.com/articles/s41586-025-08952-w
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Said goodbye to Ana and Cassiano last night. Best of luck in Brazil!!!
9 months ago
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Kara Marshall
9 months ago
Gave a talk at my parentsā retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. Iām happy to share slides with anyone who asks- just get in touch!
youtu.be/BY_SFgi-Cig
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Kara Marshall PHD-History of Science in America - Trilogy at Tehaleh 04/27/25
YouTube video by Steve Lawson
https://youtu.be/BY_SFgi-Cig
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Annabelle Singer
10 months ago
Check out our latest paper today in Nature: āGoal specific hippocampal inhibition gates learningā
www.nature.com/articles/s41...
By Nuri Jeong, Xiao Zheng, Abby Paulson, Steph Prince and colleagues.
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Keri Martinowich
11 months ago
academic.oup.com/brain/articl...
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On the responsibilities of intellectuals and the rise of bullshit jobs in universities
You may never have considered yourself to be one. Why would you? But if youāre reading this, there is more than a likelihood that you are one. If youāre a
https://academic.oup.com/brain/article/148/3/687/8058558
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www.cell.com/neuron/fullt...
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Closed-loop modulation of remote hippocampal representations with neurofeedback
Animal models of memory retrieval trigger retrieval with cues and measure retrieval using behavior. Coulter etĀ al. developed a neurofeedback paradigm that rewards hippocampal activity patterns associa...
https://www.cell.com/neuron/fulltext/S0896-6273(24)00923-1
11 months ago
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Paul Frankland
about 1 year ago
It's the post-"standard model" age! Our Preview of a fantastic new study from Yi Zhong's lab on the role of the hippocampus in updating remote memories. Fun putting this together with Ali Golbabaei.
authors.elsevier.com/a/1kZ4f3BtfH...
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Mark Jacob
about 1 year ago
Iām old enough to remember when a person who dumped a dead bear cub in New Yorkās Central Park and tried to make it look like a bike accident might have trouble getting confirmed as Health and Human Services secretary.
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Caitlin Mallory
about 1 year ago
1/19 Iām thrilled that my postdoctoral work, with John Widloski and David Foster is now out in
@science.org
, along with a wonderful preview by Daniel Bendor!
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The time course and organization of hippocampal replay
The mechanisms by which the brain replays neural activity sequences remain unknown. Recording from large ensembles of hippocampal place cells in freely behaving rats, we observed that replay content i...
https://www.science.org/doi/10.1126/science.ads4760?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
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The Transmitter
about 1 year ago
Cells in the hippocampus encode not only information about a fellow batās position, but also its identity and distinct social features. By
@claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/social-behav...
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Dean Buonomano
about 1 year ago
Some thoughts on why I think the sister fields of Neuroscience and AI will diverge going forward.
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Paul Frankland
about 1 year ago
Just giving this a boost for those who may not have seen it yet... we have a PI position (molecular and cellular basis of cognition) at The Hospital for Sick Children (Toronto). The position comes with an appointment at Assist/Assoc Prof level at U of T. Share widely!
can-acn.org/scientist-se...
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Scientist/Senior Scientist ā Research Institute, Hospital for Sick Children, University of Toronto ā Canadian Association for Neuroscience
https://can-acn.org/scientist-senior-scientist-research-institute-hospital-for-sick-children-university-of-toronto/
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Hugo Spiers
about 1 year ago
New modelling of how episodic memory can arise from spatial mapping, just out in Nature:
www.nature.com/articles/s41...
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Episodic and associative memory from spatial scaffolds in the hippocampus - Nature
A neocorticalāentorhinalāhippocampal network model based on grid cell states recapitulates experimental results and reconciles the spatial, associative and episodic memory roles of the hippocampus.
https://www.nature.com/articles/s41586-024-08392-y
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The locus coeruleus helps clear waste from the brain during sleep - interesting!
www.sciencedirect.com/science/arti...
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Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep
As the brain transitions from wakefulness to sleep, processing of external information diminishes while restorative processes, such as glymphatic remoā¦
https://www.sciencedirect.com/science/article/pii/S0092867424013436?via%3Dihub
about 1 year ago
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Merry Christmas ššš
about 1 year ago
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If you're using TetTag mice to label "engram cells" you might be interested in our recent paper. We discovered an issue with a popular strain from Jackson that contains fos-shEGFP. Endogenous levels of c-Fos expression appear to be massively increased when performing IHC.
doi.org/10.3389/fnbe...
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Frontiers | Abnormal c-Fos expression in TetTag mice containing fos-EGFP
https://doi.org/10.3389/fnbeh.2024.1500794
about 1 year ago
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Tom McHugh
about 1 year ago
New paper from Yuichi Makino and Yi Wang, building on Yuichiās earlier work on physiological signatures of memory age, here he adds data from the amygdala and Yi's ML skills to predict the age of a memory from raw LFP and offer insight to the neurobiology,
www.nature.com/articles/s41...
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Multi-regional control of amygdalar dynamics reliably reflects fear memory age - Nature Communications
Differential neural dynamics in the amygdala that define recall of different ages of fear memory remain not fully understood. Here, the authors show by both experiments and modeling that multiregional...
https://www.nature.com/articles/s41467-024-54273-3
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Very interesting š¤
www.nature.com/articles/s41...
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Formation of long-term memory without short-term memory revealed by CaMKII inhibition - Nature Neuroscience
Inhibiting CaMKII impairs short-term memory (STM) in mice during an avoidance task but does not affect long-term memory (LTM). This suggests that STM and LTM are processed differently, with CaMKII cri...
https://www.nature.com/articles/s41593-024-01831-z
about 1 year ago
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Mazen Kheirbek
about 1 year ago
I am excited that my first Bluesky post is to share our new paper in
@natureportfolio.bsky.social
- "Understanding the neural code of stress to control anhedonia." With
@fxia.bsky.social
,
@valeriafascianelli.bsky.social
and
@stefanofusi.bsky.social
.
www.nature.com/articles/s41...
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Understanding the neural code of stress to control anhedonia - Nature
Examination of the neural activity in the basolateral amygdala and ventral CA1 of mice during tasks or rest following exposure to social stress reveals signatures of resilience and susceptibility to s...
https://www.nature.com/articles/s41586-024-08241-y
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