Hillscape cells: Hippocampal place cells map terrain geometry independently of behavior #neuroskyence @roddy-grieves.bsky.social Eleonore Duvelle and Jeff Taube: www.science.org/doi/10.1126/...

New preprint from the lab. @markgergues.bsky.social and crew show that the PVT gates ventral hippocampal salience coding, shifting output between threat- and reward-weighted representations during associative learning and anxiety-related behavior. www.biorxiv.org/content/10.6...

The locus coeruleus, which provides norepinephrine to the rest of the brain, is even more spatially and functionally diverse than previously thought, new findings suggest. By Holly Barker www.thetransmitter.org/locus-coerul...

Sharing the latest from the lab. Led by Yunlong Liu, this work explores how microglia and engram neurons interact during fear extinction in the hippocampus. rdcu.be/fgNH7

this is the way

Uncovering the architecture of aging. Very cool work! 🧪

Is spatial navigation innate? The grid cell code exists before navigation experience 🧪🧠

Deconstruction of a memory engram 🧪🧠

Nice work from JJ DYN-O-MITE 🧪🧠

Brain cells on a chip learn to play Doom 🤯🧪🧠 youtu.be/yRV8fSw6HaE

Place cells in space 🚀 🧪🧠

Stuff like this blows my mind 🧪🧠

Teaching my class about fear behaviors today and found this gem online 😅 🧪🧠 www.youtube.com/watch?v=jTZG...

Place cells exhibit no local topography 🧪🧠

CA1 is more than just a spatial map with task signals layered on top 🧪🧠

Excited to share our study in Neuron led by @travisgoode.bsky.social, a K99 PDF (interviewing for Faculty) and Sahay lab team with collaborators at BROAD, Hopkins, and UW Seattle, defining a neural circuit that links prior experience with feeding behavior. Open Access: sahaylab.com/publications

How does neuronal gene expression evolve over time in response to experience? CytoTape will help us find out - a major milestone for neuroscience, providing new ways to study memory & aging 🧠 Congrats to the whole team! Looking forward to our continued collaboration on this work 🎉

Epstein-Barr Virus #EBV was linked to #MultipleSclerosis - now a plausible cause has been found, misidentification by longterm memory T-cells that pick on the wrong protein, ANO2, instead of the EBV-antigen. Massive inflection towards the elimination of MS!!! 🧪🧠Cell www.cell.com/cell/fulltex...

Can humans & animals really use internal maps to take shortcuts? Tolman famously said yes - based largely on his Sunburst maze. Our new review & meta-analysis suggests evidence is far weaker than you might think. 🧵👇 doi.org/10.1111/ejn.... @uofgpsychneuro.bsky.social @ejneuroscience.bsky.social

What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...

Reminder - a great job opportunity at @ucdavis.bsky.social Dean, College of Biological Sciences jobs.sciencecareers.org/job/676649/d...

A must-read review. It argues that brain areas are only one of several organizing principles and are not especially central, given their weak correspondence to function. Cytoarchitecture and connectivity are a starting point, not the endpoint. www.nature.com/articles/s41... #neuroscience

This new preprint by @katewassum.bsky.social is 🔥 Really solid work. It's a must read

This new ERC study uses an overlapping set of human 🧠 donors as our just dropped locus coeruleus preprint. Availability of data from both regions in the same donor facilitates our current efforts to analyze molecular signaling across the circuit, which is highly vulnerable in Alzheimer's disease.

Thoughtful review with some good recent historical perspective on the ongoing paradigm shift that is radically changing the way we think about what brain areas do. www.nature.com/articles/s41...

One for the heredity scolds: construct a multi-tissue GRM where people are differentially related to themselves. www.nature.com/articles/d41...

I don't see a lot of people talking about this, so I want to highlight something GOOD Billie Eilish stood in a room full of billionaires and said "you're billionaires... Why?" She donated 11.5 MILLION DOLLARS to food equity and climate orgs, which Stephen Colbert announced to said billionaires.

Excited to share the latest from the lab on the molecular mechanisms of silencing and un-silencing a hippocampal engram ensemble. Was fun using a variant of the EPSILON technique developed by Adam Cohen's lab. (1/2) www.sciencedirect.com/science/arti...

New paper from the lab 🚨 Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age: authors.elsevier.com/a/1lzT-3BtfH...

I am excited to share my PhD work on head-direction cells recorded in the wild, now published in @science.org, where we recorded neurons in bats flying outdoors on an island. doi.org/10.1126/sci... With @ray-neuro.bsky.social, Shir Maimon, Liora Las, Nachum Ulanovsky and many others

Very interesting work by the Yin lab! 🤔

How prediction error drives memory updating: role of locus coeruleus–hippocampal interactions: Trends in Neurosciences www.cell.com/trends/neuro...

New paper from the lab led by Ali Golbabaei. If you’re interested in systems consolidation, generalization and hippocampal neurogenesis a short 🧵 follows: authors.elsevier.com/a/1lsO73QW8S...

So proud🤩: Beautiful work by @clykken.bsky.social 💃🏻 et al: finally we understand how the hippocampus can express multiple maps even though grid cell inputs are universal metrics. E.g. hippocampal global remapping was induced when different grid modules anchored independently to environments. See 👇🏽

When a typo in your Google search leads to new and exciting philosophical positions

Thrilled to share that our work is now published in Science! ✨ We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭 www.science.org/doi/10.1126/... 🧵1/

MLK Jr. on violence:

Mice are always smarter that we expect, here guessing the trail ahead rather than just blind following. Cool work:

When the PI hasn't worked in at the bench in years but needs to do something in the lab for a photoshoot

Green Day at Bottlerock 2025 🤘

I’m excited to share a new paper from the lab. The study led by Xiaowei Gu reveals how the mPFC encodes complex emotional memories, using an internal model to infer emotional associations and memories via projections to the amygdala. a🧵(1/8) rdcu.be/el19t

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation. rdcu.be/el18q A short thread follows for those interested. 1/n

A wonderful day for science, to see the (peri) #LC in all its glory. A ginormous effort from all involved, and a fantastic resource for the field. Chapeau 🎩 🧠 🔵 www.nature.com/articles/s41...

Said goodbye to Ana and Cassiano last night. Best of luck in Brazil!!!

Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig

Check out our latest paper today in Nature: “Goal specific hippocampal inhibition gates learning” www.nature.com/articles/s41... By Nuri Jeong, Xiao Zheng, Abby Paulson, Steph Prince and colleagues.

It's the post-"standard model" age! Our Preview of a fantastic new study from Yi Zhong's lab on the role of the hippocampus in updating remote memories. Fun putting this together with Ali Golbabaei. authors.elsevier.com/a/1kZ4f3BtfH...

I’m old enough to remember when a person who dumped a dead bear cub in New York’s Central Park and tried to make it look like a bike accident might have trouble getting confirmed as Health and Human Services secretary.