Sharing a exciting study by Howard Trachtman and colleagues in Lancet demonstrating efficacy of a targeted therapy for genetic FSGS. Exciting development and blueprint for tackling other genetic kidney diseases. thelancet.com/journals/lancet/article/PIIS0140-6736(25)02255-X/abstract?rss=yes

Predicting better lipids: In a cover-winning @natbiotech.nature.com paper, the Anderson & Langer Labs screened 1.6M lipids in silico to speed up successful designs for mRNA delivery to lungs. www.nature.com/articles/s41...

Genes regulate kidney stones. In our recent editorial, Ken Saida and I review the evolving landscape of Mendelian genetics in KSD and discuss findings from a large cohort analysis in cJASN: doi.org/10.2215/CJN.... @harvardmed.bsky.social @bostonchildrens.bsky.social

In our new @natcomms.nature.com study, we show that intergenic splicing of the NS disease gene/actin regulator NOS1AP is essential for kidney filter function via transcriptomic, proteomic, human genetic & mouse model studies. @harvardmed.bsky.social @bostonchildrens.bsky.social t.co/2xegr1OUlm