Histone H3 availability is more important for development than H3.2 versus H3.3 subtype identity www.biorxiv.org/content/10.6... Nice work from @gene-marie-3.bsky.social!

Now published here! doi.org/10.1038/s443... @efapostolou29.bsky.social @stadtfeldlab.bsky.social @kritikakasliwal.bsky.social

Excited to share that my most recent work with Kaushiki is now out! See this thread by @stadtfeldlab.bsky.social. As with much of science, the middle of this project felt very murky for a time, before we worked out what was going on. Matthias has hauntingly represented this in his thread.

Very excited to announce that our collaborative study with @efapostolou29.bsky.social on the transcriptional mechanisms distinguishing totipotent and pluripotent cells has been published (link.springer.com/article/10.1...). #totipotency #ZGA #stemcells #epigenetics #chromatin

I'm really happy to announce that my two main postdoctoral works have been published in the same issue of Developmental Cell! First, the final form of the mouse cortical organoid protocol (tinyurl.com/bddfmx8n), which I recently presented at Development presents (tinyurl.com/36udcpme) and…

Epigenetics Update - Three-dimensional regulatory hubs support oncogenic programs in glioblastoma bit.ly/4iDk8Ec Howard A. Fine and Effie Apostolou (Weill Cornell Medicine) reporting in Mol Cell #Epigenetics #GBM --- High-resolution insights without cell sorting at epigenometech.com

Our work on the regulation is out www.cell.com/stem-cell-re...! Congrats to our collaborators in the Vierbuchen and Mezey labs. It turns out that genetic variation has to be very much considered if you want to harness stem cells safely in biomedicine. #pluripotency #epigenetics #stemcells

Post-mitotic transcriptional activation and 3D regulatory interactions show locus- and differentiation-specific sensitivity to cohesin depletion https://www.biorxiv.org/content/10.1101/2025.02.13.638153v1

And a second study in collaboration with Dr. Fine, led by the talented Sarah Breves, Dafne Di Giammartino and Alex Polyzos revealing the role of hyperconnected 3D hubs in controlling broader oncogenic programs in glioblastoma and other cancers. www.biorxiv.org/content/10.1...

Kaushiki and I are excited to share our preprint about fate restriction in pluripotent cells! We show that EHMT2 counteracts the reactivation of clusters of totipotency genes by nucleating heterochromatin domains at LINE-1 repeats. 1/n @efapostolou29.bsky.social and Stadtfeld Labs #DevBio 🧬🖥️