Brooke M. Emerling
@bemerling.bsky.social
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reposted by
Brooke M. Emerling
Cosimo Commisso
5 months ago
Thrilled to share our first collaboration with
@bemerling.bsky.social
🎉 Fantastic work by first author Dr. Gurpreet Arora showing how PI5P4Kα fuels pancreatic cancer cell fitness and reveals a new therapeutic vulnerability.
www.cell.com/cell-reports...
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PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer
PI5P4Kα is a critical metabolic gatekeeper in PDAC, promoting glucose and iron acquisition to support tumor survival. Arora et al. demonstrate that PI5P4Kα suppression disrupts the metabolic flexibili...
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00970-2
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reposted by
Brooke M. Emerling
Cosimo Commisso
9 months ago
New preprint with
@bemerling.bsky.social
+ first author Dr. Preeti Arora: PI5P4Kα supports pancreatic cancer cell survival by maintaining iron. Knockdown disrupts iron homeostasis, triggers apoptosis, and blocks tumor growth. A potential new target.
www.biorxiv.org/content/10.1...
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PI5P4Kα Regulates Iron Balance to Promote Metabolic Fitness in Pancreatic Cancer
Phosphoinositide kinases generate distinct phosphoinositides that regulate processes that maintain cellular fitness. Phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) have garnered interest for the...
https://www.biorxiv.org/content/10.1101/2025.04.07.647654v1.full.pdf+html
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reposted by
Brooke M. Emerling
Nature Reviews Cancer
9 months ago
#REVIEW 🚨 Brooke Emerling & Co
@sbpdiscovery.bsky.social
@bemerling.bsky.social
#REVIEW
summarize the roles of phosphatidylinositol 4-kinases
#PI4Ks
and phosphatidylinositol phosphate kinases
#PIPKs
in cancer. 📖 ⬇️
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Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities - Nature Reviews Cancer
In this Review, Emerling and colleagues summarize the roles of phosphatidylinositol 4-kinases (PI4Ks) and phosphatidylinositol phosphate kinases (PIPKs) in cancer. They highlight the altered expression of these kinases in tumours and discuss ongoing efforts in developing therapies targeting these lesser-studied phosphoinositide kinase families.
https://bit.ly/4iQunoF?utm_source=dlvr.it&utm_medium=bluesky
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