McDevitt Laboratory (@mcdevittlab.bsky.social)

🚀 PhD Opportunity on Infectious Diseases and #AMR! 🧬🔬 Are you passionate about understanding how #bacteria acquire essential #biometals and cause disease? We have fully funded joint PhD project (@thedohertyinst.bsky.social) with Prof. Trevor Moraes (@utoronto.ca). To find out more: bit.ly/4pMfmI4

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Molecular Insights into Emerging Determinants of Bacterial Zinc Homeostasis : Find an Expert : The University of Melbourne Klebsiella pneumoniae is a Gram-negative opportunistic pathogen and a World Health Organization (WHO) priority organism, owing to rising rates of multidrug resistance and the increasing burden of infections in both community and healthcare settings. These challenges, together with the lack of an effective vaccine, highlight an urgent need to identify new therapeutic targets for the treatment of K. pneumoniae infections. Zinc is an essential first-row transition metal ion required by all forms of life. In bacteria, zinc has critical roles in cellular physiology and virulence. This PhD project will employ state-of-the-art molecular, structural, and elemental analytical techniques to characterise newly identified systems involved in K. pneumoniae zinc acquisition and resistance. The project will examine how these systems contribute to evasion of host innate immune responses and antimicrobial resistance. Insights gained from this work will provide a strong foundation for the development of novel therapeutics targeting bacterial metal homeostasis pathways. http://bit.ly/4pMfmI4