Lizzy Smyth
@lizzysmyth.bsky.social
π€ 1034
π₯ 1189
π 20
Oncologist. Cancer Research π©ββοΈ. Clinical Trials π§¬π. Oxford Irish.
#Oncsky
π’It's
#ESMO
election time! I am delighted to be nominated for ESMO Director of Education π ALL the nominees are fantastic representing the global
@myesmo.bsky.social
community π πfor all the good wishes Rules this year for social media so that's it from me! Now please vote π³οΈ!
7 months ago
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We've spent 2024 discussing RT trial results in gastroesophageal cancer. My radiation oncology mate Som helps me make sense of it all below... 2024 Top Story in Oncology: The Role of Radiotherapy in Operable Gastro-Oesophageal and Gastric Cancer β Time for Change
prac.co/l/22cfph7u
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2024 Top Story in Oncology: The Role of Radiotherapy in Operable Gastro-Oesophageal and Gastric Cancer β Time for Change
Written by Elizabeth Smyth MD Written by Somnath Mukherjee MD, MRCP, FRCR, FRCP
http://prac.co/l/22cfph7u
about 1 year ago
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Eileen Parkes
about 1 year ago
When the Western really has to work (via DPhil student text) Good to see the old methods live on
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Toni Choueiri, MD
about 1 year ago
Just published in
#ESMOopen
results from our trial of IO-naive patients with advanced kidney cancer with PD1/CTLA4 and PD1/LAG3!
www.esmoopen.com/article/S205...
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DEFINE_ME
https://www.esmoopen.com/article/S2059-7029(24)01843-X/fulltext
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Paolo Tarantino, MD
about 1 year ago
Twitter, as we knew it, is gone, stained by new horrific algorithms that promote misinformation. π¦ is a much better place for those interested in science. And itβs growing fast. Thanks @jamiedoggett for highlighting our efforts to rebuild a safe place for scientific discussion.
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Good to see our protocol paper for DECIPHER in press at ESMO GO! ctDNA 𧬠after surgery will detect pts with HER2β gastroesophageal
#cancer
at high risk of recurring π§¬β receive TDxD instead of usual post-op chemo Hope to
#cure
some micrometastatic cancers π
www.sciencedirect.com/science/arti...
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Evaluating trastuzumab deruxtecan in patients with gastrooesophageal adenocarcinoma who are ctDNA and HER2 positive: DECIPHER
Operable gastrooesophageal adenocarcinoma (GOA) is treated with multimodality therapy which is curative in <50% of patients. Patients in the UK with oβ¦
https://www.sciencedirect.com/science/article/pii/S294981982400075X
about 1 year ago
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Toni Choueiri, MD
about 1 year ago
Our latest in
@naturecomms.bsky.social
from
@danafarber.bsky.social
/
@mskcc.bsky.social
collaboration: AI to extract cancer outcomes in EMR!
www.nature.com/articles/s41...
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Paolo Tarantino, MD
about 1 year ago
OS results of KN-522 out in @NEJM. Terrific news: adding pembro to neoadjuvant chemo for TNBC saves lives (5% 5-year Ξ). Bad news: weβre stuck with giving 5 drugs to all patients with stage II-III TNBC, with permanent toxicity for many. Biomarkers, please!
t.co/8S9YWOP1lr
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Nice work from my (ex π₯) fellow
@acammarota.bsky.social
ππ Examining PD-L1 expression in RCTs of chemo vs. chemo-ICI in operable GEA we show: β Strong link between PD-L1 and pathological response. βοΈ Less so OS ..
www.esmogastro.org/article/S294...
Looking forward to MATTERHORN next year!
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PD-L1 as a response biomarker to chemotherapy plus immune checkpoint inhibitors in operable gastroesophageal adenocarcinoma: a meta-analysis of neoadjuvant clinical trials
Perioperative chemoimmunotherapy [i.e. chemotherapy plus immune checkpoint inhibitor (ICI) (ChTβICI)] is an investigational treatment for operable gastroesophageal adenocarcinoma (GEA) with unclear ou...
https://www.esmogastro.org/article/S2949-8198%2824%2900068-2/fulltext
about 1 year ago
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Padmanee (Pam) Sharma, MD, PhD
about 1 year ago
www.nature.com/articles/s41...
Sharing our latest review article to highlight the importance of appropriately developing combination strategies for immune checkpoint therapy. Grateful for working with 3 brilliant scientists: Sangeeta Goswami, Kristen Pauken & Linghua Wang
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Next-generation combination approaches for immune checkpoint therapy - Nature Immunology
In this Review, Sharma and colleagues describe the current landscape of combination therapies and discuss requirements for the development of effective combination strategies.
https://www.nature.com/articles/s41590-024-02015-4
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Paolo Tarantino, MD
about 1 year ago
Regular abstracts from
#SABCS24
are out! 3407 pages of new breast cancer discoveries. Find them here:
sabcs.org/Portals/0/Do...
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https://sabcs.org/Portals/0/Documents/Full%20Abstracts%20minus%20embargoed_FINAL.pdf?ver=L9oce4fvzC42Ui4sDUmMwQ%3d%3d
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Julie Gralow
about 1 year ago
ASCO annual meeting 2025 abstract submitter open - closes Jan 28th. To support global innovation in cancer research, payment waivers offered to 1st authors from low- & lower-middle-income countries (World Bank)! Apply for a waiver when you submit an abstract
conferences.asco.org/am/abstract-...
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ASCO Meetings
https://conferences.asco.org/am/abstract-submission-requirements
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Best case series ever π€£..
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about 1 year ago
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Looking forward to seeing the other institutions & societies join too... I've been lobbying mine π
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about 1 year ago
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Tatiana Prowell, MD
about 1 year ago
NEW
#Oncology
: EGFR expression mediates resistance to T-DXd (EGFR overexpression β¬οΈ HER2 homodimerization & HER2/ADC internalization) Combining with EGFR mAbs restored HER2/ADC trafficking & β¬οΈ activity in nonclinical models
#DrugDevelopment
#OncoSky
www.cell.com/cell-reports...
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EGFR-directed antibodies promote HER2 ADC internalization and efficacy
Gupta etΒ al. demonstrate that high EGFR expression mediates resistance to HER2 antibody drug conjugates (ADCs) including trastuzumab deruxtecan (T-DXd) by limiting HER2/ADC internalization. The additi...
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00539-1
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MinhTri Nguyen, MD
about 1 year ago
@valdesan.bsky.social
to the rescue! Oncology Vol 1 and 2 starter packs (links included in the packs)
go.bsky.app/UP8aWPd
#medsky
#oncsky
#oncosky
#oncology
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Good new for BTC patients!
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about 1 year ago
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Amy C. Moore, PhD
about 1 year ago
Reclaiming our joy
#MedSky
#OncSky
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go.bsky.app/GKXp9Fy
Happy Friday! Sharing oncology starter pack
#2π
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about 1 year ago
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VJOncology
about 1 year ago
November is gastric cancer awareness month and we are sharing updates in the field β At
#ESMO24
, we spoke with Jessie Elliott on long-term survivorship concerns of patients with esophageal and gastric cancer. πSee the video below! π
https://buff.ly/48WQh5R
#stcsm
#gism
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Long-term survivorship concerns of patients with esophageal and gastric cancer - VJOncology
Jessie Elliott, FRCS, PhD, Trinity St. Jamesβs Cancer Institute, Dublin, Ireland, discusses the long-term survivorship concerns of patients with esophageal...
https://buff.ly/48WQh5R
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Better late than never ππ!
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about 1 year ago
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Lizzy Smyth
Emil Lou, MD,PhD,FACP
about 1 year ago
Right on time for
#NANETS2024
: the North American Neuroendocrine Tumor Society is on
@bsky.app
! Lots of posts to come from the NET community over the next three days during the Annual Symposium taking place in
#Chicago
.
@oncothor.bsky.social
@cancertrials.bsky.social
@halletjulie.bsky.social
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Vivek Subbiah, MD
about 1 year ago
π¨The exodus of
#MedTwitter
#OncSky
to
#BlueSky
@bsky.app
is fascinating. All the
#Twitter
birds are now flying freely in the Bluesky. π¦π Will
#Bluesky
succeed where
#Threads
and
#Mastodon
struggled?#MedTwitterMigration
#BlueSkySocial
@oncoalert.bsky.social
@tmprowell.bsky.social
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β Should we switch chemotherapy for patients with gastroesophageal cancer after 3 months? ARMANI trial published in Lancet Oncol today βοΈ Patients who switched to 2L pac/ram after 3m of OxFU had β¬οΈ PFS and OS than patients who continued 1L chemo β....but also β¬οΈ hospital visits & toxicity.
about 1 year ago
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This oncology starter pack belowππΌ is worth a follow..
#findyourpeople
#medsky
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about 1 year ago
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Johanna Joyce
about 1 year ago
Inspired by the other amazing starter packs - here's one for cancer researchers! I tried to make this broad - from immunology to genomics to cell biology and so much more.. This list also includes organizations & institutes supporting cancer researchers π§ͺπ¬βοΈπ©Ί Hope its useful!
go.bsky.app/FEoaJMc
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Brian Wallach
about 1 year ago
Once an activist, always an activist.
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π Great to see this published! VESTIGE is a negative randomised trial with an important lesson.. β‘οΈ Give adjuvant FLOT even when there's residual cancer after neoadjuvant chemo. π Looking forward to the translational work
annalsofoncology.org/article/S0923-β¦
about 1 year ago
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