Excited to be part of this collaborative work on telomere biology in pluripotent cells. We found that nonsense-mediated mRNA decay (NMD) becomes essential for cell survival in the absence of TRF2, by preventing production of a dominant-negative TRF1 isoform. www.nature.com/articles/s41...

Uncovering the isoform-resolution kinetic landscape of nonsense-mediated mRNA decay with EZbakR https://www.biorxiv.org/content/10.1101/2025.03.12.642874v1

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.