Melanie de Wit
@mmdewit.bsky.social
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PhD candidate Vrije Universiteit Amsterdam Studying Autism
pinned post!
(1/9) 📣 OUT NOW! 📣 So excited to share that our systematic review and meta-analysis on the autism polygenic score is now published in JAACAP Open
@jaacapjournals.bsky.social
.
doi.org/10.1016/j.ja...
A (long) thread of our main findings ⤵️
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https://doi.org/10.1016/j.jaacop.2025.04.001
5 months ago
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(1/9) 📣 OUT NOW! 📣 So excited to share that our systematic review and meta-analysis on the autism polygenic score is now published in JAACAP Open
@jaacapjournals.bsky.social
.
doi.org/10.1016/j.ja...
A (long) thread of our main findings ⤵️
loading . . .
Redirecting
https://doi.org/10.1016/j.jaacop.2025.04.001
5 months ago
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reposted by
Melanie de Wit
Psychiatric Genomics Consortium (PGC)
6 months ago
🔎Looking for a clear overview of autism genetics?🔍 This 2021 Psychological Medicine paper provides just that!
www.cambridge.org/core/journal...
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Genetic contributions to autism spectrum disorder | Psychological Medicine | Cambridge Core
Genetic contributions to autism spectrum disorder - Volume 51 Issue 13
https://www.cambridge.org/core/journals/psychological-medicine/article/genetic-contributions-to-autism-spectrum-disorder/89240047F6928249D9DE91A6A6CFBD52
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reposted by
Melanie de Wit
Psychiatric Genomics Consortium (PGC)
6 months ago
Some autistic people are diagnosed early 👶, others much later 🧑🎓. This new preprint finds that age of diagnosis links to different genetic and behavioral profiles. Such axes help explain why autism can look so different from one person to another.
tinyurl.com/cexv5uh5
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An axis of genetic heterogeneity in autism is indexed by age at diagnosis and is associated with varying developmental and mental health profiles
There is growing recognition that earliest signs of autism need not clearly manifest in the first three years of life. To what extent is this variation in developmental trajectories associated with ag...
https://tinyurl.com/cexv5uh5
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reposted by
Melanie de Wit
Psychiatric Genomics Consortium (PGC)
6 months ago
📣Out now 📣 In a GWAS meta-analysis,
@angelicaronald.bsky.social
and colleagues identified 11 independent genome-wide significant loci associated with age at onset of walking.
www.nature.com/articles/s41...
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Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry - Nature Human Behaviour
A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and gene...
https://www.nature.com/articles/s41562-025-02145-1?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20250507&utm_content=10.1038/s41562-025-02145-1#Abs1
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reposted by
Melanie de Wit
Genetics Network Amsterdam
9 months ago
(in Dutch): Interessant interview met
#GENEAmsterdam
wetenschappers
@mmdewit.bsky.social
en
@tincatwin.bsky.social
: 'Erfelijk of ontwikkeld: hoe ontstaat autisme?' over hartnekkige misverstanden, de interpretatie van erfelijkheid en de invloed van externe factoren.
www.quest.nl/mens/psychol...
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Erfelijk of ontwikkeld: hoe ontstaat autisme?
Kinderen krijgen in Nederland gemiddeld pas rond hun vijfde de diagnose 'autisme'. Toch is neurodiversiteit in grote mate erfelijk. Hoe zit dat? Hoe ontstaat autisme?
https://www.quest.nl/mens/psychologie/a63569971/autisme-erfelijk/
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reposted by
Melanie de Wit
Michel Nivard
11 months ago
No posts yet but this is a grassroots network of Amsterdam geneticists, crosses disciplines, institutions & career stage. All run out of passion on a shoestring budget. Great way to strike up collaborations!
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https://bsky.app/profile/geneamsterdam.bsky.social
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Join us tomorrow for what I'm sure will be an interesting session on Science Outreach!
add a skeleton here at some point
11 months ago
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reposted by
Melanie de Wit
11 months ago
Last Thursday, Thomas and
@mmdewit.bsky.social
shared insights on sex differences in autism and diagnostic ratios at an
#AutismeCafe
— bringing science beyond the department. Great discussions with autistic people and parents followed!
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