Claire McCarthy
@clairem402.bsky.social
📤 3118
📥 4946
📝 933
scientist with a PhD in toxicology | views are my own
Listening to Porch Light by
@noahkahan.bsky.social
:
youtu.be/hQSO9vFXnBU
#Musicsky
#MusicMonday
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Noah Kahan - Porch Light (Official Lyric Video)
YouTube video by NoahKahanVEVO
https://youtu.be/hQSO9vFXnBU
about 11 hours ago
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#MarchMovieChallenge
#Moviesky
#Filmsky
Day 16: Movie which takes place in a military academy Cadet Kelly
add a skeleton here at some point
about 11 hours ago
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Claire McCarthy
Letterboxd
about 22 hours ago
Ryan Coogler wins Best Writing (Original Screenplay) for Sinners
#Oscars
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Claire McCarthy
Letterboxd
about 23 hours ago
KPop Demon Hunters wins Best Animated Feature Film
#Oscars
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Drop something VAMPY 🧛🏻♀️🦇🖤⚰️🧛🏻♂️
add a skeleton here at some point
about 11 hours ago
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#MarchMovieChallenge
#Moviesky
#Filmsky
Day 15: Movie filmed or set in Maine It
add a skeleton here at some point
1 day ago
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Claire McCarthy
Science Magazine
3 days ago
The emergence of AI tools is not only helpful in cancer
#neuroscience
, but may be a necessary step to decode the highly complex networks that connect cancer cells to the nervous and immune systems, researchers argue in a new
#ScienceSignaling
Focus.
https://scim.ag/3P61s6j
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AI might be the next stage of our natural evolution: A cancer neuroscience perspective
Understanding the interactions between cancer and the nervous system may require AI-based analytics.
https://scim.ag/3P61s6j
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Claire McCarthy
Science Magazine
2 days ago
Are you celebrating
#PiDay
with pie ... or do you prefer cake? Researchers have designed a robot that can create and cook a cake with more than π ingredients. Learn more:
https://scim.ag/4s1fOU1
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Claire McCarthy
Cell Press
4 days ago
Cell Press: Championing real-world impact.
www.cell.com/about?utm_so...
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Claire McCarthy
Nature
4 days ago
Nature research paper: Ageing promotes metastasis via activation of the integrated stress response
go.nature.com/4uoWp0M
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Ageing promotes metastasis via activation of the integrated stress response - Nature
Ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrated stress response, and a therapeutic opportunity in older patients is revealed.
https://go.nature.com/4uoWp0M
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Claire McCarthy
Nature
3 days ago
The rates of more than a dozen cancers are increasing among adults under the age of 50. What are the reasons behind it?
go.nature.com/4cKxhLN
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Why are so many young people getting cancer? What the data say
Clues to a modern mystery could be lurking in information collected generations ago.
https://go.nature.com/4cKxhLN
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Claire McCarthy
Nature
2 days ago
Scientists say they have made some of the first direct measurements of how long it takes a protein to fold – and the results were surprising
go.nature.com/4s3xlec
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How fast does a protein fold? Real-time technique captures the moment
Nature - Proteins assume complex 3D shapes even faster than does DNA, which is a simpler molecule.
https://go.nature.com/4s3xlec
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Claire McCarthy
Cancer Cell
4 days ago
Lymph node colonization induces tissue remodeling via immunosuppressive fibroblast-myeloid cell niches supporting metastatic tolerance
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Lymph node colonization induces tissue remodeling via immunosuppressive fibroblast-myeloid cell niches supporting metastatic tolerance
Haist et al. demonstrate that lymph node (LN) colonization induces systems-wide LN remodeling in patients with head-and-neck cancer using multiplex imaging, spatial transcriptomics, and a melanoma model of LN metastasis. The authors identify spatially organized immunomodulatory myeloid/CAF niches as key features of metastatic tolerance that associate with T cell dysfunction and Treg activation beyond the tumor-colonized LN.
http://dlvr.it/TRRny1
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Claire McCarthy
Cancer Cell
4 days ago
IGSF11-VISTA is a critical and targetable immune checkpoint axis in diffuse midline glioma
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IGSF11-VISTA is a critical and targetable immune checkpoint axis in diffuse midline glioma
Collot et al. profile tumor and immune interactions in DMG. They identify DMG tumor cells that communicate with microglia through IGSF11-VISTA signaling. Targeting this communication pathway leads to tumor control by microglia and a favorable disease outcome. This positions IGS11-VISTA as a promising brain-specific therapeutic axis for DMG treatment.
http://dlvr.it/TRRyQ6
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Claire McCarthy
Cancer Cell
3 days ago
Framework for cancer evolution profiling and interception in colorectal cancer: ASCEND-CRC program
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Framework for cancer evolution profiling and interception in colorectal cancer: ASCEND-CRC program
Cancer evolution is a complex and dynamic process, yet most treatment strategies remain static. Infrequent tumor sampling has limited our ability to counteract the transient adaptive states that precede resistance. To address this gap, ARPA-H launched the ADAPT program, an initiative aimed at transforming cancer care by aligning therapies with real-time tumor evolution. Within this framework, the ASCEND-CRC trial aims to uncover early adaptive mechanisms and identify biomarkers to guide therapeutic decision-making in metastatic colorectal cancer (CRC). The study moves beyond single pre-treatment biomarkers by integrating multimodal profiling to longitudinally track tumor evolution and define an actionable set of dynamic biomarkers that inform treatment decisions. Together with other ADAPT initiatives, ASCEND-CRC represents a paradigm shift in precision oncology, establishing a scalable platform to intercept resistance.
http://dlvr.it/TRTM5Y
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Claire McCarthy
Michelle Tran, PhD
4 days ago
Excited to share the final first-author paper of my PhD is online in Cancer Discovery
@aacrjournals.bsky.social
!
doi.org/10.1158/2159...
We identify an SPP1⁺ macrophage–IL-6–CRP inflammatory axis linked to resistance to checkpoint blockade in bladder cancer
@bhardwajlab.bsky.social
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Drop something BROWN 🐻🧥🖤🍫🐕
add a skeleton here at some point
1 day ago
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Claire McCarthy
Scientific American
1 day ago
Snakes are key members of their ecosystems. Here’s what would happen if they suddenly vanished just like in the Oscar-nominated film Zootopia 2
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What would happen if snakes disappeared like in Zootopia 2? An investigation
Snakes are key members of their ecosystems. Here’s what would happen if they suddenly vanished just like in the Oscar-nominated film Zootopia 2
https://www.scientificamerican.com/article/what-zootopia-2-gets-right-about-the-science-of-snakes/
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#MarchMovieChallenge
#Moviesky
#Filmsky
Day 14: Scientist in a Movie Jurassic Park
add a skeleton here at some point
2 days ago
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Claire McCarthy
Benzie, the puppies Penn & Teller, and Richard
2 days ago
Happy pi day!
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Claire McCarthy
Lizzylizumab
2 days ago
Happy Pi Day 🥧
add a skeleton here at some point
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Claire McCarthy
Museum of Science
2 days ago
Did you know you can figure out pi using pie ingredients? 🥧🧪
@alexdainis.bsky.social
uses pecans to explore Buffon’s needle, a famous probability problem that can help estimate pi.
youtube.com/shorts/59pAw...
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Can Pecans Measure Pi?
YouTube video by Museum of Science
https://youtube.com/shorts/59pAwekdnI4?feature=share
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Claire McCarthy
C&EN (Chemical & Engineering News)
2 days ago
These blocks contain precisely measured fluorescent dyes dispersed in polymethyl methacrylate, according to Starna Cells. Analytical chemists use them to calibrate the lamps and detectors in fluorescence-based spectroscopy instruments.
cen.acs.org/analytical-c...
#CENChemPics
#chemsky
🧪
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Claire McCarthy
Foijer Lab
4 days ago
Very beautiful work to which we made a small contribution. Congrats to
@eileenparkes.bsky.social
and team!
#CIN
#Immunesurveillance|
Science Advances
www.science.org/doi/10.1126/...
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Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS–chemokine–myeloid axis
Chromosomal chaos rewires immune defense into tumor-promoting inflammation.
https://www.science.org/doi/10.1126/sciadv.aeb1611
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#MarchMovieChallenge
#Moviesky
#Filmsky
Day 13: Working dog in a movie Balto
add a skeleton here at some point
3 days ago
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If you see this, post a vampire that isn't Dracula.
add a skeleton here at some point
3 days ago
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If you see this, post a robot .....🤖
add a skeleton here at some point
3 days ago
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What's a line delivery you'll never forget?
add a skeleton here at some point
3 days ago
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Claire McCarthy
Where in the World
4 days ago
#WomensHistoryMonth
Day 12 - Conservationist and writer Rachel Carson helped spark the
#environmental
movement with her book 'Silent' Spring', about the dangers of pesticides. Where in the World...did she write 'Silent Spring'? Click to find out:
www.whereintheworldgame.com?id=214&type=q
#Science
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Claire McCarthy
Eric Topol
4 days ago
Aging, stress inside cells, and promoting cancer metastasis
www.nature.com/articles/s41...
AT4 is the effector of the integrated stress response, enriched in patients of advanced age with cancer and correlated with poor survival (Figure)
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#MarchMovieChallenge
#Moviesky
#Filmsky
Day 12: Coca Cola in a Movie The Breakfast Club
add a skeleton here at some point
4 days ago
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Claire McCarthy
Science Magazine
5 days ago
🎉 The overall winner of this year’s
#DanceYourPhD
contest is Sofia Papa. She and five other dancers re-create the piezoelectric effect, the ability of some crystalline materials to generate electricity when subjected to stress. Learn more:
https://scim.ag/4rtrGgq
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Claire McCarthy
Nature
6 days ago
Nature research paper: Precancerous niche remodelling dictates nascent tumour persistence
go.nature.com/4l8AgzC
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Precancerous niche remodelling dictates nascent tumour persistence - Nature
A study investigating the emergence of squamous tumours in the upper gastrointestinal tract of the mouse shows that an initial tumour stress response triggers fibroblasts to remodel the underlying stroma, creating a fibronectin-rich precancerous niche that supports tumour survival.
https://go.nature.com/4l8AgzC
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Claire McCarthy
Cancer Cell
6 days ago
A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma
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A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma
Rade et al. present a longitudinal single-cell atlas of BCMA CAR-T therapy in multiple myeloma, revealing that cilta-cel drives potent CD4⁺ cytotoxic responses and superior outcomes. Their findings identify plasmacytoid dendritic cells as unexpected BCMA-expressing targets and suggest therapeutic potential in blastic plasmacytoid dendritic cell neoplasm.
http://dlvr.it/TRPj1z
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Claire McCarthy
Cancer Cell
5 days ago
Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth
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Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth
Mateus-Tique et al. demonstrate that targeting FOLR2+ or TREM2+ tumor-associated macrophages with IL-12-expressing CAR-T cells eliminates immunosuppressive macrophages and unleashes endogenous anti-tumor immunity, leading to tumor clearance and improved survival in models of metastatic cancers.
http://dlvr.it/TRQrBM
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Claire McCarthy
Cancer Cell
5 days ago
CCL3 is produced by aged neutrophils across cancers and promotes tumor growth
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CCL3 is produced by aged neutrophils across cancers and promotes tumor growth
Bolli et al. develop a classifier that rescues neutrophils typically lost in scRNA-seq data, enabling unified pan-cancer analyses. This approach identifies CCL3hi aged tumor-associated neutrophils conserved across human and mouse cancers. Mechanistic perturbations show that neutrophil-derived CCL3 drives their CCR1-dependent survival in hypoxic niches, thereby promoting tumor progression.
http://dlvr.it/TRR6nQ
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Claire McCarthy
Daniel MacPhee 🇨🇦
5 days ago
“With the Human Organ Atlas (HOA), users can travel through the brain, heart, lungs, kidneys, and liver and better understand our anatomy and the diseases that threaten it. The platform is detailed in a paper published today in the journal Science Advances” 🧪
#Scicomm
www.popsci.com/health/human...
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Explore the human body in stunning, 3D detail with a new online tool
The free Human Organ Atlas gives users an up-close-and-personal look at 56 human organs.
https://www.popsci.com/health/human-organ-atlas/
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“Anything is possible when you have the right people there to support you.” - Misty Copeland
#WednesdayWisdom
5 days ago
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#MarchMovieChallenge
#Moviesky
#Filmsky
Day 11: Parents of a LGBTQ character in a movie Aristotle and Dante Discover the Secrets of the Universe
youtu.be/ukLWHUBAPJI
add a skeleton here at some point
5 days ago
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Choose your top 25 favorite cartoons. One per day for 25 days, in no particular order. No explanations, no reviews. Day 25: Schoolhouse Rock!
add a skeleton here at some point
5 days ago
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Claire McCarthy
Magdalena Skipper
6 days ago
What does science really tell us about skincare? Skin is sometimes described as the largest organ in the human body. Turns out advice on how to look after it is rarely based on real science. Nor does it emphasize the link with overall health 🧪
www.nature.com/articles/d41...
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Forget SkinTok: the real science of skincare and why it matters for your health
Skip the complicated regimens and expensive products seen on social media. The science of skin is deep but the recommendations are simple.
https://www.nature.com/articles/d41586-026-00700-y
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Claire McCarthy
C&EN (Chemical & Engineering News)
6 days ago
Chemists and innovative recyclers are trying to turn gloves, pipette tips, and other laboratory plastic waste into something useful.
#chemsky
🧪
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Chemistry labs make tons of plastic waste. Can we recycle it?
Chemists and innovative recyclers are trying to turn gloves, pipette tips, and other laboratory plastic waste into something useful
https://cen.acs.org/environment/recycling/recyling-gloves-plastic-lab-waste/104/web/2026/03?sc=260310_sc_eng_bs_cen
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Claire McCarthy
C&EN (Chemical & Engineering News)
6 days ago
Analysis of 85 pieces of Mesolithic pottery from hunter-gatherer-fisher communities in northeastern Europe shows the value of combining analytical techniques to improve the understanding of ancient diets and cooking methods.
#chemsky
🧪
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How ancient pottery preserves plant-eating proof
Organic residues on pots from northern and eastern Europe show plants were an important part of the local diet several thousand years ago
https://cen.acs.org/analytical-chemistry/art-&-artifacts/ancient-pottery-preserves-plant-eating-proof/104/web/2026/03?sc=260310_sc_eng_bs_cen
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Claire McCarthy
Kris Willis
6 days ago
More reporting from
@statnews.com
on the struggling pipeline for new antibiotics to treat drug-resistant infections
www.statnews.com/pharmalot/20...
Challenges at the earliest, most fraught stages of drug development are likely a contributing factor.
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Large drugmakers are developing fewer antibiotics, analysis finds
The number of potential antimicrobial treatments being developed by the world’s largest drugmakers nosedived by 35% over the past five years, according to a new analysis.
https://www.statnews.com/pharmalot/2026/03/10/drugmakers-develop-fewer-antibiotics-antimicrobials/
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#MarchMovieChallenge
#Moviesky
#Filmsky
Day 10: Favorite pop song used in a movie Dirty Dancing (I’ve Had) The Time of My Life
add a skeleton here at some point
6 days ago
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Choose your top 25 favorite cartoons. One per day for 25 days, in no particular order. No explanations, no reviews. Day 24: Ed, Edd n Eddy
add a skeleton here at some point
6 days ago
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Claire McCarthy
Science Magazine
7 days ago
Of the many impressive acrobatic qualities of cats, perhaps their most spectacular is their ability to right themselves midair so they always seem to land on their feet. The trick lies in a hyperflexible region of their backbone known as the thoracic spine, a new study finds.
https://scim.ag/4rlHodw
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Claire McCarthy
Nature
7 days ago
“In the past, it might have seemed like, ‘ah, that’s likely never going to work’,” says physicist Ania Jayich. “That’s not true any more.”
go.nature.com/3NdJMF1
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Why ‘quantum proteins’ could be the next big thing in biology
Fluorescent proteins with a quantum upgrade could offer unprecedented views inside cells.
https://go.nature.com/3NdJMF1
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Claire McCarthy
Cancer Cell
7 days ago
B cells disrupt tertiary lymphoid structure formation and suppress anti-tumor immunity
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B cells disrupt tertiary lymphoid structure formation and suppress anti-tumor immunity
Chen et al. find that a specific B cell subset is associated with immunotherapy resistance in bladder cancer. IGLL5+ B cells interact with HEVs through IGLL5-LTβR signaling, leading to the impairment of TLSs formation in humanized mouse models. This interaction presents a promising therapeutic target for overcoming immunotherapy resistance in bladder cancer.
http://dlvr.it/TRNrbw
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Claire McCarthy
Waggoner Lab
7 days ago
How fast does a protein fold? Real-time technique captures the moment
@nature.com
www.nature.com/articles/d41...
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How fast does a protein fold? Real-time technique captures the moment
Proteins assume complex 3D shapes even faster than does DNA, which is a simpler molecule.
https://www.nature.com/articles/d41586-026-00755-x
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