Claire McCarthy
@clairem402.bsky.social
📤 2700
📥 4777
📝 643
scientist with a PhD in toxicology | views are my own
November Movie 30 Day Challenge Day 10: A Superhero Movie Wonder Woman
m.imdb.com/title/tt0451...
#Filmsky
#moviesky
add a skeleton here at some point
about 3 hours ago
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Claire McCarthy
about 13 hours ago
Dr. Florence Sabin | Immunologist and educator, born
#OTD
in 1871. The first woman to hold a full professorship at Johns Hopkins School of Medicine (where she graduated from in 1900) and the first woman elected to the National Academy of Sciences.
#WomenInSTEM
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Nature
about 8 hours ago
Getting Rosalind Franklin’s story right is crucial, because she has become a role model for women going into science
www.nature.com/articles/d41...
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What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
https://www.nature.com/articles/d41586-023-01313-5
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November Movie 30 Day Challenge Day 9: A Movie From Your Favorite Director The Dark Knight
en.wikipedia.org/wiki/The_Dar...
#Filmsky
#moviesky
add a skeleton here at some point
about 23 hours ago
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Claire McCarthy
Nature Metabolism
2 days ago
RESEARCH | T Feng, Q Luo, J Yun et al (
@mdanderson.bsky.social
) The combination of glucose and fructose in sugar-sweetened beverages promotes colorectal cancer metastasis via sorbitol dehydrogenase 🧪
www.nature.com/articles/s42...
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Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD - Nature Metabolism
Feng, Luo and colleagues show that the combination of glucose and fructose, as found in sugar-sweetened beverages, promotes colorectal cancer metastasis through a mechanism involving sorbitol dehydrog...
https://www.nature.com/articles/s42255-025-01368-w?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
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Claire McCarthy
Shicheng Guo
2 days ago
Synthetic fluorophores enhance live-cell microscopy, enabling nanoscale to macroscale imaging with improved resolution. PMID:41188619, Nat Chem Biol 2025, @nchembio
https://doi.org/10.1038/s41589-025-02038-4
#Medsky
#Pharmsky
#RNA
#ASHG
#ESHG
🧪
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Synthetic fluorophores for live-cell fluorescence microscopy and biosensing | Nature Chemical Biology
Fluorescence microscopy has become an indispensable tool to investigate the dynamics of macromolecules directly in living cells on length scales ranging from the nanoscale via super-resolution microscopy (SRM) to the macroscale by light sheet technology. Advances in these microscopy techniques and the desire to perform experiments with high spatial and temporal resolution in living cells increase the requirements imposed on the fluorophores used. Tailor-made synthetic small-molecule fluorophores in combination with innovative labeling strategies help to overcome these challenges and continue to push the boundaries in live-cell microscopy. This Review discusses important advances in improving the performance of synthetic fluorophores for live-cell applications and how synergistic effects can be produced by using clever labeling strategies. We detail how synthetic fluorophores advance different microscopy modalities including live-cell SRM and showcase how they can be implemented into bi
https://doi.org/10.1038/s41589-025-02038-4
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Claire McCarthy
Ele Willoughby
1 day ago
Happy birthday to
#inventor
Hedy Lamarr (1914 – 2000) & Hollywood star. 🧪🐡👩🏼🔬
#histsci
Born Hedwig Keisler in Vienna, she gained fame after her risqué & notorious starring role in Machatý’s ‘33 film Ecstasy. Mandl, 1st of 6 husbands, objected & tried unsuccessfully to buy all copies of film.
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Drop something GOLD 🏆👑🖤🔱🥇
add a skeleton here at some point
about 23 hours ago
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Claire McCarthy
Cancer Cell
3 days ago
Online Now: Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions
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Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions
By single-cell and spatial transcriptomics analysis, Peng et al. reveal that alveolar progenitors are the earliest predecessor of LUAD and reside in epithelial-proinflammatory niches that are more common in premalignant stages and enriched with IL-1β-IL1R1 signaling. Targeting IL-1β and these niches in mice reduces alveolar progenitors and development of LUAD.
http://dlvr.it/TP7RRW
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Claire McCarthy
Cancer Cell
3 days ago
Online Now: Cellular senescence in precancer lesions and early-stage cancers
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Cellular senescence in precancer lesions and early-stage cancers
Cellular senescence plays dual roles in precancer lesions: initially serving as a tumor-suppressive barrier within the epithelial compartment and later contributing to a pro-tumoral precancer tissue microenvironment (PreTME) via a sustained, paracrine secretome known as senescent-associated secretory phenotype (SASP). This commentary highlights the role of senescence across various PreTME cell types, explores emerging pharmacologic and lifestyle interception strategies, and outlines current challenges for advancing biomarkers and clinical translation.
http://dlvr.it/TP7c9S
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Cancer Cell
3 days ago
Online Now: Decoding the spatial dynamics of tumor and immune cell interactions in solid cancers
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Decoding the spatial dynamics of tumor and immune cell interactions in solid cancers
The spatial landscape of the tumor immune microenvironment (TIME) is under significant investigation as a driver of immunotherapy resistance in solid tumors. Most work centers on constituent immune cells within intra-tumoral niches, overlooking tumor cell phenotypes. Yet cancer cells shape their milieu by multiple modalities, including secreting and depleting metabolites. Here, we argue that integrating cancer cell phenotypic heterogeneity into spatial analyses is essential to reveal the mechanisms that generate TIME diversity and to better address resistance to immunotherapy.
http://dlvr.it/TP7tKD
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Claire McCarthy
Science Magazine
4 days ago
Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis. Learn more this week:
https://scim.ag/4nFEGO7
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Claire McCarthy
Nature
3 days ago
Scientists have created the most detailed maps yet of how our brains differentiate from stem cells during embryonic development and early life
go.nature.com/4qIpjr3
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First ever atlas of brain development shows how stem cells turn into neurons
A collection of studies that chart how mammalian brain cells grow and differentiate is a ‘very valuable’ tool for neuroscientists.
https://go.nature.com/4qIpjr3
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November Movie 30 Day Challenge Day 8: A Movie with Your Favorite Actor The Bourne Identity
m.imdb.com/title/tt0258...
#Filmsky
#moviesky
add a skeleton here at some point
2 days ago
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Claire McCarthy
bioRxiv Cell Biology
2 days ago
HeartMap: An Integrated Cell Atlas of 2.4 million cells across 209 Individuals in Health and Disease
https://www.biorxiv.org/content/10.1101/2025.11.06.686995v1
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Virginia Silio
2 days ago
Sharing this, quite relevant this week.
www.thelancet.com/journals/lan...
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Remembering my sister Rosalind Franklin
Rosalind Franklin died of ovarian cancer in 1958 aged 37 years. Sympathy and feminism have combined to give us her familiar image as a downtrodden woman scientist, brilliant but neglected, a heroine t...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)60452-8/fulltext
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Claire McCarthy
MU-Peter Shimon 🀄
2 days ago
🔆 Happy
#NationalSTEMday
Every November 8th... National STEM Day is a reminder of how science, technology, engineering and math help us to ask questions, solve problems and imagine a better world. National STEM Day: What is it and Why is it Important? 🧪
stemhunter.com/national-ste...
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Princess Vimentin PhD | Cancer Biologist
2 days ago
3D organoid culture technology is a growing field & exists for a variety of cell types & cancers. Brain organoids or lab grown “reductionist replicas” of the human brain help scientists to understand fetal development & cognitive disorders, including autism. 🧪🎁 🔗
www.nytimes.com/2025/11/06/s...
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What We Can Learn From Brain Organoids
https://www.nytimes.com/2025/11/06/science/brain-organoids-neurons.html?unlocked_article_code=1.zk8.uKnd.dBhkO8bNOxbj&smid=nytcore-ios-share&referringSource=articleShare
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Claire McCarthy
Nature Portfolio
2 days ago
Researchers from BICAN have expanded their cell-type atlases to include developing human, mouse, and non-human primate brains using multimodal genomics, which was published in Nature. 🧪
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BICCN: A cell census of the developing human brain
Expanding cell-type atlases to include developing human, mouse and non-human primate brains using multimodal genomics.
https://go.nature.com/4qJ1I9y
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Dr Chris Earl (MOL-BIO)
2 days ago
🧪My first article was accepted for a Medium publication: "Science Spectrum" If you use Medium, please clap and follow 🙏 It's about the Molecular Revolution and how it reshaped our understanding of life — and why its next phase could decide our fate.
medium.com/science-spec...
#science
#philsky
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The Molecular Revolution in Biology
How molecular biology reshaped our understanding of life — and why its next phase could decide our fate.
https://medium.com/science-spectrum/the-molecular-revolution-in-biology-0a99521dfe61
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Claire McCarthy
Robert “The Baste God” McNees
2 days ago
Wilhelm Röntgen discovered X-rays
#OTD
in 1895 when he noticed that emanations from a Crookes tube caused a platino-barium screen to fluoresce. The rays exposed photographic plates but were blocked by bone and metal. This early plate shows his wife's hand. 🧪 ⚛️ Image: Wellcome Trust
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Freya Harrison
2 days ago
What Rosalind Franklin truly contributed to the discovery of DNA’s structure. A really informative article, perfect for a weekend coffee read.
www.nature.com/articles/d41...
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What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
https://www.nature.com/articles/d41586-023-01313-5
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Check out some
#CoolScienceImages
(with music by The Faim) from the
@natureportfolio.nature.com
collection of the BRAIN Initiative Cell Atlas Network (#BICAN).
www.nature.com/collections/...
#neuroscience
#FluorescenceFriday
🧪
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3 days ago
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November Movie 30 Day Challenge Day 7: Film with a One Word Title Once
m.imdb.com/title/tt0907...
#Filmsky
#moviesky
add a skeleton here at some point
3 days ago
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Claire McCarthy
The Batlle Lab
3 days ago
1/17 🧵 🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇 ➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC). Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
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TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages - Nature Genetics
Targeting TGFBR1 in transplantable mouse colorectal tumor organoids improves response to anti-PD-L1 therapy. Mechanistically, TGF-β abrogates clonal expansion of T effector and memory phenotypes and i...
https://www.nature.com/articles/s41588-025-02380-2
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Claire McCarthy
Cancer Grand Challenges
3 days ago
💡 New research from the
#CancerGrandChallenges
NexTGen team offers a way to make CAR T-cell therapy more effective — even against cancers that try to hide. 📖 Read the open-access paper in Nature Cancer:
doi.org/10.1038/s43018-025-01056-4
#Immunotherapy
#CART
#PaediatricOncology
#CancerResearch
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Engineering T cells with a membrane-tethered version of SLP-76 overcomes antigen-low resistance to CAR T cell therapy - Nature Cancer
Majzner and colleagues show that engineering T cells with a membrane-tethered version of the signaling adaptor molecule SLP-76 alongside a chimeric antigen receptor (CAR) enhances CAR T cell activity ...
https://doi.org/10.1038/s43018-025-01056-4
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Claire McCarthy
Nature Methods
3 days ago
Squidiff: a diffusion-based model to predict transcriptome response to perturbations.
www.nature.com/articles/s41...
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Squidiff: predicting cellular development and responses to perturbations using a diffusion model - Nature Methods
Squidiff is a diffusion-based model to predict transcriptomic changes in response to perturbations.
https://www.nature.com/articles/s41592-025-02877-y
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Claire McCarthy
Nature Methods
3 days ago
CABLE: a method that uses information about cell or nuclear shape to infer fiber tracts in the brain.
www.nature.com/articles/s41...
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Whole-brain reconstruction of fiber tracts based on cytoarchitectonic organization - Nature Methods
CABLE harnesses cytoarchitectural information such as cell or nuclear shape to infer fiber tracts in the brain of, for example, marmosets, macaques or humans.
https://www.nature.com/articles/s41592-025-02865-2
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Claire McCarthy
Science Magazine
3 days ago
New findings in
#ScienceSignaling
show that cells called leukocytes have a surface “coating” that can be modified during inflammatory conditions, such as
#psoriasis
, revealing how immune cells are recruited to sites of inflammation.
https://scim.ag/4osBp5U
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Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during psoriasis-like skin inflammation
Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate.
https://scim.ag/4osBp5U
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Claire McCarthy
Cell - a Cell Press journal
3 days ago
Now online! StealTHY: An immunogen-free CRISPR platform to expose concealed metastasis regulators in immunocompetent models
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StealTHY: An immunogen-free CRISPR platform to expose concealed metastasis regulators in immunocompetent models
By sidestepping Cas9 immunogenicity, the StealTHY CRISPR platform enables immune-compatible in vivo genetic screens, directly translatable to humanized cancer models. Using this immune-stealth strategy allows for the discovery of metastatic drivers and reveals the AMH-AMHR2 axis as a clinically actionable pathway for dampening carcinoma metastasis.
http://dlvr.it/TP7fS8
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Claire McCarthy
Keri Martinowich
3 days ago
For
#FluorescenceFriday
- one of my favorites from the archives of a neuron ⚪ and astrocyte 🟢 co-culture. Image credit to Stephanie Page and former research assistant Beth Pattie 🧠🔬🧪
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Ele Willoughby
3 days ago
Happy birthday to Marie Skłodowska-Curie (1867 – 1934, Polish-born, naturalized-French
#physicist
&
#chemist
at work in her lab. The contents of her lab glassware in my print appropriately glow-in-the-dark! 🧪🐡👩🏼🔬
#histsci
Marie Curie was the 1st woman to win a Nobel prize, the only woman to ever win
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November Movie 30 Day Challenge Day 6: A Film That Is Set In Space Aliens
m.imdb.com/title/tt0090...
#Filmsky
#moviesky
add a skeleton here at some point
4 days ago
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Claire McCarthy
Kristina Killgrove
5 days ago
I think this is a pretty cool proof of concept... even if the resulting knits look a little janky, lol. 🧪🧶
news.cornell.edu/stories/2025...
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Knitting machine makes solid 3D objects | Cornell Chronicle
A multicollege team has developed a prototype of a knitting machine that creates solid, knitted shapes, adding stitches in any direction so users can construct a wide variety of shapes and add stiffne...
https://news.cornell.edu/stories/2025/11/knitting-machine-makes-solid-3d-objects
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Claire McCarthy
Waggoner Lab
5 days ago
Hot New Clues for Treating Immune ‘Cold’ Tumors
@cincyresearch.bsky.social
scienceblog.cincinnatichildrens.org/hot-new-clue...
www.science.org/doi/10.1126/...
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Johanna Joyce
5 days ago
New issue of Nature - with NINE studies on
#brain
#development
from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬 An amazing set of resources for all scientists working on the brain! 🧠 Immersive feature:
www.nature.com/immersive/d4...
🧠 Perspective:
www.nature.com/articles/s41...
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Drop something BLUE 👖🦋🖤🧞♂️🫐
add a skeleton here at some point
4 days ago
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Growing up were there any moments in movies that traumatized you? 😬
add a skeleton here at some point
4 days ago
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Claire McCarthy
C&EN (Chemical & Engineering News)
4 days ago
How much do you know about the chemistry of spices? Test your knowledge of what spice chemicals can do besides seasoning food.
cen.acs.org/biological-c...
#chemsky
🧪
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Quiz: How much do you know about the chemistry of spices?
Test your knowledge of what spice chemicals can do besides seasoning food.
https://cen.acs.org/biological-chemistry/Quiz-much-know-chemistry-spices/103/web/2025/11?sc=251106_sc_eng_bs_cen
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Museum of Science
4 days ago
Science isn’t a solo mission, it’s a team effort. 🧪 Dr. Raychelle Burks is a chemist who thrives on collaboration, using the power of forensic science to solve real-world problems. Her work shows how diverse minds working together can spark big breakthroughs.
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Science Magazine
6 days ago
A new
#ScienceImmunology
study in mice has identified stem-like tissue-resident memory T cells that can reactivate and regulate immune responses in the intestines, which could inform future
#immunotherapies
against gastrointestinal tumors or chronic infections.
https://scim.ag/4hJTaeH
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Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine
Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall.
https://scim.ag/4hJTaeH
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Claire McCarthy
Science Magazine
6 days ago
AI cell models could transform biomedicine—if they work as promised.
https://scim.ag/3Jeou8A
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Can AI capture the mind-boggling complexity of a human cell?
Researchers are competing to make “virtual cells” that could transform biomedicine by predicting gene activity and more
https://scim.ag/3Jeou8A
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Claire McCarthy
Nature
6 days ago
“I think there’s a collective amnesia right now about COVID-19” SARS-CoV-2 infections have been rising in the past month, and limited surveillance is hampering health strategies
go.nature.com/3LeRVbd
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COVID-19 is spreading again — how serious is it and what are the symptoms?
Limited COVID-19 surveillance data are hampering vaccination and health strategies, researchers say.
https://go.nature.com/3LeRVbd
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Nature
5 days ago
Nature research paper: Origins of chromosome instability unveiled by coupled imaging and genomics
go.nature.com/43MBKYN
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Origins of chromosome instability unveiled by coupled imaging and genomics - Nature
Coupling live-cell imaging, machine learning and genomic sequencing, the MAGIC platform enables investigation of the cellular context, mutation rates and triggers of spontaneous chromosomal abnormality formation, shedding light on fundamental determinants of chromosomal instability.
https://go.nature.com/43MBKYN
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It's Book Quote Wednesday and the word is COLOR. “I think it pisses God off if you walk by the color purple in a field somewhere and don't notice it.” - The Color Purple by Alice Walker
#Booksky
#bookqw
add a skeleton here at some point
5 days ago
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“One day you'll look back and realise how hard it was, and just how well you did.”
@charliemackesy1.bsky.social
#WednesdayWisdom
5 days ago
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November Movie 30 Day Challenge Day 5: A Movie Based on a True Story Hidden Figures
m.imdb.com/title/tt4846...
#Filmsky
#moviesky
add a skeleton here at some point
5 days ago
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Claire McCarthy
Lara K. Mahal
6 days ago
Proud of our latest
#glycotime
review. Co-authored by my amazing cancer collaborator Dr. Eva Hernando and our students
@faezehjame.bsky.social
, Tigist Batu and Kylie Prutisto-Chang. 🧪 Glycosylation in Cancer: From Functional Roles to Therapeutic Implications -
www.annualreviews.org/content/jour...
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Glycosylation in Cancer: From Functional Roles to Therapeutic Implications
The field of cancer glycobiology aims to understand how aberrant glycosylation contributes to the development of cancer. While the significance of glycosylation to normal and pathological cellular fun...
https://www.annualreviews.org/content/journals/10.1146/annurev-cancerbio-060625-123845
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Nature Biotechnology
5 days ago
Research Highlight: Combining CRISPR perturbations with chromatin profiling
www.nature.com/articles/s41...
add a skeleton here at some point
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Claire McCarthy
PLOS Biology
5 days ago
PRMT5 is a
#HistoneMethyltransferase
upregulated in various cancer types. This study shows that PRMT5 regulates TCF3
#AlternativeSplicing
under
#hypoxia
and that this promotes
#EMT
and invasion of
#BreastCancer
cells
@plosbiology.org
🧪
plos.io/48ZbZrT
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