New preprint reveals bacteria can't just collect all resistance genes like Pokemon cards. We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...

"Honey, wake up. New CUT protocol just dropped" www.biorxiv.org/content/10.1...

Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...

The original circos plot? From the 1947-1948 Carnegie Yearbook, the page prior to McClintock's Mutable Loci in Maize paper.

1/ Excited to share our latest opinion piece published today in Trends in Microbiology (@cp-trendsmicrobiol.bsky.social): Hypermutator fungal pathogens: from threat to meltdown Here, we argue that the origin of hypermutation follows defined principles, rather than...

The first paper of my PhD is now available as a preprint! 🎉 Transposable elements (TEs) don't just jump within fungal genomes, they also move extensively between species. In this study, we screened over 1,300 fungal genomes and found a conservative estimate of 5,500+ horizontal transfer events.

Excited to share the first PhD preprint of @iglavincheska.bsky.social — now on bioRxiv! We explored the 3D genome of Zymo and found: 🧬 Rabl-like conformation 🧩 Accessory chr tethered to core centromeres 🏰 Self-interacting domains and boundaries with insulator motifs www.biorxiv.org/content/10.1...