🚀 Motivation boost to kick off the new year 🙂: The European Commission agreed to provide a 6-month-long extension to A-TANGO! Let's use this momentum and move forward swiftly now, so that A-TANGO can bring the much-needed G-TAK therapy for severe #AlcoholicHepatitis #cirrhosis #ACLF to the market.

🫖 Snuggle in with a cup of tea and a blanket over the holidays to read this year's MICROB-PREDICT publications - Wishing everyone relaxing winter holidays and a wonderful start into the New Year! ❄️ 📖 microb-predict.eu/for-scientis... @medblab.bsky.social @easlnews.bsky.social @ec.europa.eu

🥂 We have good news for the holidays: The technical hold-up in the EU portal has finally been resolved & we submitted the 3rd #PeriodicReport ☺️ Wishing everyone relaxing holidays❄️ Together, we are moving from bench to bedside to bring innovative therapies to #ACLF patients @rajivjalan.bsky.social

🚀 AF-B-STEP launches on 01 January 2026 🚀 🌐 afbstep.eu A global collaboration redefining atrial fibrillation (AF) - from “yes” or “no” to what really matters. We analyse data from 100,000+ people to quantify the global burden of AF - aiming to improve diagnosis, treatment and outcomes. #HeartHealth

As the year draws to a close, we are wrapping up 2025 with gratitude, momentum, and a spirit of community at concentris. ✨ 💡Curious about what’s next in 2026, and how these developments could support your work? Read our latest #newsletter: 🔗 mailchi.mp/concentris/n...

👏 New study from Dávid Tornai and colleagues 🎉: Serum #Villin1 is a promising non-invasive marker of #GutBarrier damage in #cirrhosis and #ACLF. It rises with severity, predicts 90-day mortality, links to #inflammation, and has been validated in an independent cohort! 📜 doi.org/10.1111/apt....

👉 In this video, Dávid Tornai (MD, PhD) from Maria Papp's group at the University of Debrecen in Hungary presents the consortium's research on serum #villin-1, a tell-tale sign of #GutBarrier failure in cirrhotic patients with acute #decompensation via a graphical abstract. 📽️ youtu.be/URerer6AxxY

📽️ Now online 🎧: lnkd.in/dJuMmsc4 Watch or listen to the newest EASL Studio Episode on “Rifaximin for Hepatic Encephalopathy: Balancing Benefits and Risks in the Era of Antimicrobial Resistance” from Wednesday, 26 Nov 2026. #rifaximin #HepaticEncephalopathy #AntimicrobialResistance #cirrhosis #ACLF

On Wednesday, 26 Nov, at 6 pm CET, EASL Studio hosts a new episode titled “Rifaximin for Hepatic Encephalopathy: Balancing Benefits and Risks in the Era of Antimicrobial Resistance” The episode will be broadcast live on EASL.eu and can be accessed here: 📹 easl.eu/easl-studio-... Don't miss it ☺️

🎉 Our new #mirobiome paper in #JHEP is out! We found distinct gut #virome shifts in #ACLF - from virulent to temperate #phages - with Lactococcus A + Enterococcus B phages linked to infections & higher 90-day mortality 👉 Read more: www.sciencedirect.com/science/arti... 📽️Video: youtu.be/0YF6qToBQUM

🌍 The MICROB-PREDICT team met in Münster, Germany from 1–2 October for its 14th Steering Committee Meeting! 👉 Team leaders discussed results from 20 new papers about late-stage #LiverDisease #cirrhosis #biomarkers and IPR topics as the project nears its final phase. The finish line is in sight!

Register for this exciting and high-calibre panel discussion on early cancer detection and the impact of artificial intelligence! 📅 15 October 2025 🕑 14 - 15:00 CEST 📍 online Register using this link: events.teams.microsoft.com/event/1fba7a... #oncology #MedSky #OncoSky

Next week: the final DECISION General Assembly in Madrid! 🎉 Celebrating 5+ years of science, collaboration, & results @rautoupe.bsky.social  @concentris.bsky.social  @navarrabiomed.bsky.social  @bioeticayderecho.bsky.social  @medblab.bsky.social  @europeliver.bsky.social  @easlnews.bsky.social et al

✨Final spotlight of this series: Our open access protocol on a self-medication #MouseModel of #ChronicPain that helps assess spontaneous #PainRelief & #DrugAbuse liability 🔗 doi.org/10.21769/Bio... Cabañero et al. (2022), co-authored by Beltrán Álvarez & Rafael Maldonado #Neuroscience #Analgesics

5️⃣ García-Blanco et al. (2002): www.jci.org/articles/vie... 📖 miRNA signatures associated with vulnerability to food addiction in mice & humans 💡Common #miRNA #signatures in mice & humans may underlie vulnerability to #FoodAddiction. 💡Targeting those miRNAs may modify maladaptive eating phenotypes.

4️⃣ academic.oup.com/ismej/articl... 📖 Presence of #Blastocystis in #GutMicrobiota associated with decreased executive function 💡Blastocystis colonisation in the gut is associated with measurable deficits in executive #CognitiveFunction, suggesting a possible #GutBrainAxis influence on cognition.

3️⃣ doi.org/10.3389/fpsy... 📖 Tetrahydrocannabinol #THC exposure in #adolescence elevates #impulsivity-like behaviour in #adulthood in a self-administration mouse model 💡Young-age THC exposure may produce a lasting impulsivity increase & neurochemical changes that predispose to #AddictiveBehaviour.

1️⃣ Del Mar Cajiao-Manrique, Maldonado & Martín-García (2023) doi.org/10.3389/fpha... 📖 A self-administration mouse model to study #CannabinoidAddiction 💡This novel #MouseModel provides a rigorous tool to study #CannabinoidAddiction & the neurobiological mechanisms of #vulnerability vs. #resilience.

🧬🐭👩‍🦰👨‍🦰 Translational research - from mice to humans - was central to #QSPainRelief: For better #PainRelief, safer #PainMedication and improved #ChronicPain treatment. ✅ Less pain 😵‍💫 Fewer side effects ☺️ Better QoL ✨ Here are 5 key papers about 🧠-mechanisms linked to #addiction #cognition #impulsivity

A more #PainRelief-relevant follow-up of the 2020 Sci. Rep. paper is this article by Ricarte, Dalton & Giraldo (2021), a year later: 🔗 doi.org/10.1021/acs.... 🧬 Structural assessment of #agonist #efficacy at the μ-opioid receptor #MOR 👉 #morphine and #fentanyl elicit different activation patterns

🔬 Wanna know the P-values for #agonist-dependent #GPCR activation? 👏 One of our 2 high-impact Nature publications was also the 1st QSPainRelief article: 📈 Bruzzese, Dalton & Giraldo (2020) present their #MolecularDynamics work & the best statistics to analyse it. 🔗 www.nature.com/articles/s41...

Here's another important QSPainRelief publication about allosteric sites at #GPCRs: They can be identified by looking at how strongly certain receptor sites are coupled to #conformational changes that occur during activation. 🔗 doi.org/10.3390/ijms... #allostery #pharmacology #receptors #ligands

Speaking of #allostery: What happens when you mutate the #CannabinoidReceptor (CB1) in silico with a single-point mutation? Find out👉: doi.org/10.1021/acso... Spoiler😉: The F237L mutation mimics #allosteric #ligand effects, globally altering #receptor conformations and hindering activation #GPCR

🎯Feature Alert 🚨 This paper delves into how #BindingKinetics reshape our understanding of #allosteric modulation. When it comes to cooperativity effects, it's all about 👉 WHERE molecules bind 👉 HOW FAST 👉 and in WHICH SEQUENCE 🔗 doi.org/10.1016/j.dr... #allostery #pharmacology #DrugDesign #GPCRs

🚀 Time-dependent #ligand-receptor #BindingKinetics and functionality in a #heterodimeric receptor model by Ortiz et al. (2024): Predicting how 2 drugs bind to a receptor complex over time - with implications for combination-therapies and #DrugDesign💊 🔗 doi.org/10.1016/j.bc... #Pharmacology #GPCRs

🔦 Spotlight on link.springer.com/article/10.1... 🧠 Using the LeiCNS-PK3.0 PBPK model, they predicted mouse #brainECF #pharmacokinetics for 10 drugs ✅ Accurate for 7 drugs ✅ First mechanistic #CNS PBPK #model in mice ✅ Strong translational potential #TranslationalPharmacology #DrugDevelopment

The paper by Budda et al. (2024) relates to the earlier publication by Gülave et al. (2023): doi.org/10.1016/j.ej... 🧠The transport of #morphine across the #BBB is non-linear - this is important for #receptor #occupancy predictions. Find out how BBB dynamics inform smarter, safer dosing strategies!

🧠 Non-linear blood-brain barrier #BBB transport & dosing influence #receptor #occupancy ratios of #morphine and #MorphineMetabolites (M3G + M6G) in the #pain matrix. 💡This might also explain some inter-individual differences! 🔗 bpspubs.onlinelibrary.wiley.com/doi/10.1111/... #ChronicPain #opioids

🔬By Bertayli et al (2024): PK-PD modelling of #morphine, #pregabalin & their combination shows synergistic #analgesia. Potential impact: 👉 Lowering #opioid doses 👉 Maintaining treatment efficacy 👉 Reducing side effects & abuse liability 🔗 www.page-meeting.org/default.asp?... #ChronicPain #Pain

📖 Just published 💊 👉 Introducing a rigorous theoretical framework for better #quantification of #drug-target #ResidenceTime (RT) - a key metric in #BindingKinetics that has lacked a firm quantitative foundation to date 👏 🔗 www.sciencedirect.com/science/arti... #Pharmacology #ComputationalBiology

🧪 Our new paper on the #pharmacokinetics of P-glycoprotein substrates in #brainECF shows how #invitro transport data can guide #invivo 🧠🐭🚶‍♀️predictions, but that high variability still limits the robustness of these predictions. 🔗 link.springer.com/article/10.1... 👉LeiCNS-PK3.4 PBPK model #CNS #brain

🫶 Our recent review shows that #SocialSupport is a powerful boost for #MentalHealth in #ChronicPain ⚡ , but its impact on pain intensity and daily function is less clear. 👉 Social support is crucial, but HOW matters 🔗 doi.org/10.1371/jour... #QoL #PainResearch #Pain @plosone.org @efic.bsky.social

🧠 Predicting how well #drug molecules cross the blood-brain barrier: Gülave et al. built a #MachineLearning model for the unbound brain-to-plasma partition coefficient (98 compounds). link.springer.com/article/10.1... 👉Best algorithm: Random Forest 💡Great for #CNS drug discovery! #BBB #PBPK #ML

💊 Morphine is a P-glycoprotein substrate, but do P-gp inhibitors meaningfully change #CNS exposure? 🧠 Likely not: A physiology-based pharmacokinetic #PBPK model predicts negligible impact across populations. #BBB #DrugInteractions #morphine #modelling #brain 🔗 link.springer.com/article/10.1...

Preoperative #susceptibility to secondary #hyperalgesia is associated with cough-evoked #pain 2 months after #thoracotomy (Gousset et al., 2025) 👉 onlinelibrary.wiley.com/doi/10.1002/... ⚕️Patients with high secondary hyperalgesia pre-op had more cough-evoked pain 2 months later. #PainPrediction

🧠 Central sensitisation drives #ChronicPain. This PhD thesis by Solenn Gousset (2025) bridges experimental pain models and clinical perspectives, exploring methods to measure and predict #CentralSensitisation. 👉 Explore the mechanisms behind persistent pain! 🔗 dial.uclouvain.be/pr/boreal/ob...

🧠 Ever wondered what affects how #morphine works in the brain? This modelling study found #beta-endorphin to be a major player in how morphine occupies its µ-opioid receptors (MORs) in rat #hypothalamus 🐭 #EndogenousOpioids matter, folks! #BindingKinetics #MOR www.sciencedirect.com/science/arti...

💡What happens when you combine 2 analgesics? 🔬 Bakker et al. (2025) used a nociceptive test battery to investigate #morphine + #pregabalin. Result: Increased #PainTolerance, only minimal side effects. A promising step toward safer #PainRelief & lower #opioid doses. pubs.acs.org/doi/10.1021/...

🔬 Read the original publication by Boglarka Balogh, David Tornai, Aniko Csillag et al. (2025) on behalf of the MICROB-PREDICT consortium and the PREDICT study group of the EASL-CLIF consortium: onlinelibrary.wiley.com/doi/10.1111/...

🚨 New #LiverFailure insights 🚨 In patients with #cirrhosis + acute #decompensation, secretory #IgA strongly correlates with #gut-barrier failure and is a powerful predictor of 90-day mortality in acute-on-chronic #LiverFailure #ACLF 👉 Watch on YouTube: youtu.be/KapUqG7AFFk #Biomarkers #GutBarrier

20% live with #ChronicPain - many without effective treatment The QSPainRelief database uses published data, existing meds & advanced models to help design more effective therapies 🎥 Intro video: youtu.be/0VWoc2fqks8 🔗 Database: qspainrelief.lacdr.leidenuniv.nl #PainRelief #PersonalisedMedicine

Join our webinar “Approaches to Early Cancer Diagnosis and the Impact of Artificial Intelligence in Oncology”! @phireproject.bsky.social, #PANCAIM & @pancaid.bsky.social are proud to discuss how AI is transforming #oncology. 🔗 Register: events.teams.microsoft.com/event/1fba7a... #CancerResearch

👏 ALB-TRIAL hits 50% enrollment 🎉 Half of the planned 240 patients have now been recruited across 14 centres in 7 countries - great progress for the MICROB-PREDICT project! Huge thanks to all site teams - Onward to full enrollment & better treatment for #cirrhosis patients with #ascites! #albumin

🎓 Dive into the complexity of #OpioidReceptors with Prof. Andrea Bedini (from @unibo.it) in his insightful Masterclass. 👉 A must-watch for anyone interested in #MOR, #KOR, and chronic pain therapeutics! ▶️ youtu.be/dcGBm03nvhI #GPCR #ChronicPain #Pharmacology @iasp.bsky.social @efic.bsky.social

For #WorldHepatitisDay we stand together 🩺 At A‑TANGO, we aim to transform healthcare for people with #LiverDisease, including those living with #cirrhosis and #ACLF, putting #patients first ☺️ Every person deserves timely, effective, and #stigma‑free support 💪 @europeliver.bsky.social @who.int

🔥 We’ve hit 50% recruitment in the #COMBATtrial! Huge thanks to all involved!💙 @rautoupe.bsky.social @hopitalbeaujon.bsky.social @hospitalclinic.bsky.social @rwth.bsky.social @uni-muenster.de @brunslab.bsky.social @medblab.bsky.social @frankuschner.bsky.social #LiverSky #ClinicalTrial

On #WorldBrainDay, we spotlight #ADHD, a brain condition with lifelong impact. TIMESPAN research reveals how it shapes risks for #obesity, #diabetes & heart disease.  More results coming soon. @easoobesity.bsky.social  #WBD2025

🔬 #PUBLICATION Alert! 🧾 𝗖𝗶𝗿𝗰𝗮𝗱𝗶𝗮𝗻 𝗿𝗵𝘆𝘁𝗵𝗺𝘀 𝗶𝗻 𝗰𝗮𝗿𝗱𝗶𝗼𝘃𝗮𝘀𝗰𝘂𝗹𝗮𝗿 𝗱𝗶𝘀𝗲𝗮𝘀𝗲 by Kelters et al. MARKOPOLO coordinator Andreas Daiber contributed to this review in the #EuropeanHeartJournal, highlighting the impact of impaired circadian rhythms on cardiovascular health. 🔗 academic.oup.com/eurheartj/ad...