💊 Morphine is a P-glycoprotein substrate, but do P-gp inhibitors meaningfully change #CNS exposure? 🧠 Likely not: A physiology-based pharmacokinetic #PBPK model predicts negligible impact across populations. #BBB #DrugInteractions #morphine #modelling #brain 🔗 link.springer.com/article/10.1...

Preoperative #susceptibility to secondary #hyperalgesia is associated with cough-evoked #pain 2 months after #thoracotomy (Gousset et al., 2025) 👉 onlinelibrary.wiley.com/doi/10.1002/... ⚕️Patients with high secondary hyperalgesia pre-op had more cough-evoked pain 2 months later. #PainPrediction

🧠 Central sensitisation drives #ChronicPain. This PhD thesis by Solenn Gousset (2025) bridges experimental pain models and clinical perspectives, exploring methods to measure and predict #CentralSensitisation. 👉 Explore the mechanisms behind persistent pain! 🔗 dial.uclouvain.be/pr/boreal/ob...

🧠 Ever wondered what affects how #morphine works in the brain? This modelling study found #beta-endorphin to be a major player in how morphine occupies its µ-opioid receptors (MORs) in rat #hypothalamus 🐭 #EndogenousOpioids matter, folks! #BindingKinetics #MOR www.sciencedirect.com/science/arti...

💡What happens when you combine 2 analgesics? 🔬 Bakker et al. (2025) used a nociceptive test battery to investigate #morphine + #pregabalin. Result: Increased #PainTolerance, only minimal side effects. A promising step toward safer #PainRelief & lower #opioid doses. pubs.acs.org/doi/10.1021/...

🔬 Read the original publication by Boglarka Balogh, David Tornai, Aniko Csillag et al. (2025) on behalf of the MICROB-PREDICT consortium and the PREDICT study group of the EASL-CLIF consortium: onlinelibrary.wiley.com/doi/10.1111/...

🚨 New #LiverFailure insights 🚨 In patients with #cirrhosis + acute #decompensation, secretory #IgA strongly correlates with #gut-barrier failure and is a powerful predictor of 90-day mortality in acute-on-chronic #LiverFailure #ACLF 👉 Watch on YouTube: youtu.be/KapUqG7AFFk #Biomarkers #GutBarrier

20% live with #ChronicPain - many without effective treatment The QSPainRelief database uses published data, existing meds & advanced models to help design more effective therapies 🎥 Intro video: youtu.be/0VWoc2fqks8 🔗 Database: qspainrelief.lacdr.leidenuniv.nl #PainRelief #PersonalisedMedicine

Join our webinar “Approaches to Early Cancer Diagnosis and the Impact of Artificial Intelligence in Oncology”! @phireproject.bsky.social, #PANCAIM & @pancaid.bsky.social are proud to discuss how AI is transforming #oncology. 🔗 Register: events.teams.microsoft.com/event/1fba7a... #CancerResearch

👏 ALB-TRIAL hits 50% enrollment 🎉 Half of the planned 240 patients have now been recruited across 14 centres in 7 countries - great progress for the MICROB-PREDICT project! Huge thanks to all site teams - Onward to full enrollment & better treatment for #cirrhosis patients with #ascites! #albumin

🎓 Dive into the complexity of #OpioidReceptors with Prof. Andrea Bedini (from @unibo.it) in his insightful Masterclass. 👉 A must-watch for anyone interested in #MOR, #KOR, and chronic pain therapeutics! ▶️ youtu.be/dcGBm03nvhI #GPCR #ChronicPain #Pharmacology @iasp.bsky.social @efic.bsky.social

For #WorldHepatitisDay we stand together 🩺 At A‑TANGO, we aim to transform healthcare for people with #LiverDisease, including those living with #cirrhosis and #ACLF, putting #patients first ☺️ Every person deserves timely, effective, and #stigma‑free support 💪 @europeliver.bsky.social @who.int

🔥 We’ve hit 50% recruitment in the #COMBATtrial! Huge thanks to all involved!💙 @rautoupe.bsky.social @hopitalbeaujon.bsky.social @hospitalclinic.bsky.social @rwth.bsky.social @uni-muenster.de @brunslab.bsky.social @medblab.bsky.social @frankuschner.bsky.social #LiverSky #ClinicalTrial

On #WorldBrainDay, we spotlight #ADHD, a brain condition with lifelong impact. TIMESPAN research reveals how it shapes risks for #obesity, #diabetes & heart disease.  More results coming soon. @easoobesity.bsky.social  #WBD2025

🔬 #PUBLICATION Alert! 🧾 𝗖𝗶𝗿𝗰𝗮𝗱𝗶𝗮𝗻 𝗿𝗵𝘆𝘁𝗵𝗺𝘀 𝗶𝗻 𝗰𝗮𝗿𝗱𝗶𝗼𝘃𝗮𝘀𝗰𝘂𝗹𝗮𝗿 𝗱𝗶𝘀𝗲𝗮𝘀𝗲 by Kelters et al. MARKOPOLO coordinator Andreas Daiber contributed to this review in the #EuropeanHeartJournal, highlighting the impact of impaired circadian rhythms on cardiovascular health. 🔗 academic.oup.com/eurheartj/ad...

What does grassroots dissemination look like? TIMESPAN works closely with people with lived experiences & organisations to make research matter. Beyond papers and conferences. Read about our approach: 🔗 timespan.eu/timespan-gra... #ADHD #TIMESPAN #Scicomm

Good to see a feature on German TV last week about social prescribing, focusing in particular on museums and arts on prescription. This includes interviews with Wolfram from Charité and Nick from the National Academy for Social Prescribing, who are both part of SP-EU. www.3sat.de/kultur/kultu...

Hey, #ADHDcommunity! How do you find & consume information about #ADHD? Take our very short, anonymous survey 👉 docs.google.com/forms/d/e/1F... 🙏 Thank you!! Your input will help us improve how ADHD-related resources and research results are shared. #AdultADHD #ADHDresearch

What an inspiring 9th Steering Committee Meeting! It was lovely to meet fellow liver-health enthusiasts & clinical investigators who recently joined the #GTAK Study. Let's include as many #ACLF patients in the study as possible.💉😊 #AlcoholicHepatitis @europeliver.bsky.social @easlnews.bsky.social

PANCAID is proud to share that coordinator Klaus Pantel will speak at the G7 Cancer conference in Paris on June 26. 🕚 11:50 AM 💬 Talk: Early diagnosis and detection of minimally residual disease in #pancreaticcancer using #liquidbiopsy More info: g7cancer-events.com #G7Cancer

🧠 Midpoint check-in! Today, PANCAID held its 6th Steering Committee meeting as we hit the halfway mark of our #HorizonEU project. WP leads aligned strategy & next steps for advancing early #PancreaticCancer detection. We’re buzzing for what’s ahead! ⚡ #CancerResearch #LiquidBiopsy

📢 New review from PANCAID's WP4: Cost-effectiveness of #earlydetection in #pancreaticcancer 🧾💶 ➡️ Some strategies work well, but inconsistencies in methods limit broader conclusions. Read the full paper: link.springer.com/article/10.1... @drchrisbrett.bsky.social #HealthEconomics

🆕 Our Annual Report is out now! It features the latest trends and achievements, from AI to climate change solutions, as well as the yearly monitoring of #HorizonEU. Explore the EU's Research & Innovation landscape in 2024. Read it here: europa.eu/!Nd6QPq

🌍 We’re bringing African & European researchers closer together under #HorizonEU. Scientists, innovators & experts from both continents will join forces to tackle shared regional & global challenges & advance the African Union - EU Innovation Agenda 🔗 europa.eu/!c4f3tx

We are delighted to say that our website is now live, with information and updates about the SP-EU programme and #SocialPrescribing social-prescribing.eu. Take a look and let us know what you think!

Join this exciting event! Don't miss our #OpenInnovation event, uniting experts in #DrugDevelopment, #bioinformatics, and #hepatology. Connect with researchers, industry professionals, and investors to share insights & explore collaboration opportunities! 🚀 Register now: inevent.uk/en/Crowdheli...

🧪 Day 2 Magic: 👉 Clinical efficacy, ethical considerations, and the final reporting 📰 👉 A power session on #dissemination, #IP, and how our #innovations will go commercial 🚀 👉 Brainstorming on next steps and funding pathways to keep our momentum going 💸 👉 Final wrap-up & virtual high-fives 🙌

🧠 Highlights from Day 1: 👉 Updates on our #QSPainRelief #ModelPlatform after a warm welcome by Liesbeth 👉 Deep dives into data management, in silico computations, cellular signalling, and preclinical validation 🔬 👉 Coffee-fueled discussions ☕ on how our model translates into real-world impact 💡

Wrapping things up for our final deliverables in fresh #SpringTime spirit: Our Steering Committee assembles for the last time as we shift into top-gear productivity 🚀until the end of June! 😎 #ChronicPain #PersonalisedMedicine #DrugCombinations #PainRelief @horizoneu.bsky.social @efic.bsky.social

🔁 EU Headed 📢 Did you miss the Horizon Europe Cluster 4 Info Days? The recordings are now available! 🔗 You can now watch the recorded sessions to get more info on the HE calls and on how to apply for #EUfunding: europa.eu/!j4DNkf

We are delighted to be joining The International Social Prescribing Showcase on 16th June, hosted by The National Academy for Social Prescribing and The International Social Prescribing Collaborative. Sign up now socialprescribingacademy.org.uk/events/nasp-...

👉 Follow the new project page for a landmark Social Prescribing EU project with partners from across Europe including many members of the ISPC 👉 Full project title: #SocialPrescribing to promote and improve #access to #health and #care services for people in #vulnerable situations in Europe

Today is #SocialPrescribingDay! We are delighted to be bringing together 22 health and research organisations in Berlin today for our first SP-EU General Assembly. Find out more about our project: Social Prescribing EU – health and care services for people in vulnerable situations

It’s great to have SP-EU colleagues together here at Charité in Berlin for our first General Assembly!

The European Citizens' Initiative has a petition calling for a ban on conversion practices for LGBTIQ people. Find out more: eci.ec.europa.eu/043/public/#...

Done several #EU projects with @concentris.bsky.social ! Has always been a pleasure!

📣 Secure your spot now 📣: inevent.uk/en/Crowdheli... Check out our upcoming (online) A-TANGO #LiverHealth Helix Event! 🟣 Industrial Perspective on #DrugDevelopment Challenges for #ClinicalTrials 🗓️ 04 June 2025 🕙 Begin: 10 am BST #ClinicalResearch @rajivjalan.bsky.social @easlnews.bsky.social

🔦 PANCAID Partner Spotlight: @concentris.bsky.social As project office & WP6 lead, concentris keeps PANCAID running smoothly, from coordination to communication, training & impact. Their expert team supports EU research from start to finish. #ResearchManagement #SciComm #HorizonEurope

#HorizonEU Work Programme 2025 has been adopted! It’s a simpler & more accessible Work Programme: 🔹 Open & less prescriptive topics 🔸 Shorter topic descriptions 🔹 Increased use of lump sums And more 👇 europa.eu/!WKg4Vq

In a Comment article for Nature, Cindy Sangalang identifies three key changes that are needed to improve understanding of trauma across generations, and to develop more-effective interventions and policies to prevent mass harms and their negative impacts in the future. 🧪

🔬 #PUBLICATION Alert! 🧾 Just published in #atherosclerosis: 𝗖𝗮𝗿𝗱𝗶𝗼𝘃𝗮𝘀𝗰𝘂𝗹𝗮𝗿 𝗿𝗶𝘀𝗸 𝗽𝗼𝘀𝗲𝗱 𝗯𝘆 𝘁𝗵𝗲 𝗲𝘅𝗽𝗼𝘀𝗼𝗺𝗲 by Andreas Daiber, Sanjay Rajagopalan, Marin Kuntić & Thomas Muenzel 🔗 Full text: www.atherosclerosis-journal.com/article/S002...

At #EASL2025, ELPA President Marko Korenjak presented 3 EU projects: A-TANGO, LIVER AIM & THRIVE. At the Layperson Events, science met real stories — patients at the center of innovation, action & hope. @liveraim.bsky.social @A-TANGO @THRIVE @korenjak.bsky.social @ninadonner.bsky.social

✅ How to reach a #consensus in science 🧬: Clinic director Frank Tacke (Charité) trains future #hepatology leaders on the #DelphiMethod, a reliable forecasting method using multiple rounds of questionnaires for an expert panel to reach a mutual agreement. 🗓️ What a fun #workshop at #EASLCongress 2025

🧪 SAT-209 – #EASL2025 MNK6106 vs. rifaximin to treat #HepaticEncephalopathy - new Phase 2a data from Prof. @rajivjalan.bsky.social (UCL) explores safety, PK & ammonia-lowering potential. HE treatment innovation in motion! #Cirrhosis

🧠 SAT-210 – #EASL2025 New tool alert! The #mHEST scale brings clarity to grading hepatic #encephalopathy in trials & clinics. A big step for #cirrhosis care. Kudos to Prof. @rajivjalan.bsky.social & his team! #LiverHealth #HE #ClinicalResearch

Live from the #EASLCongress: Debbie Shawcross (KCL) presents on Rebooting immunity: Harnessing FMT to revive innate defences in #cirrhosis as part of the Symposium “Microbiome and liver health: Unveiling new therapeutic pathways” 🦠🧫 #EASL2025 @easlnews.bsky.social @kingscollegelondon.bsky.social

🔬 Improving the prognostic performance of the #MELD score is a challenge that Nikolaj Torp (Odense University Hospital) took on, comparing the original score with MELD 3.0 in 777 patients with an acute #decompensation of #cirrhosis #POSTER SAT-196-YI 👏 📅 Presented at #EASLCongress | #EASL2025

✨ #PosterTour today at #EASLCongress 2025: All our 3 Horizon2020 #LiverResearch projects in 1 session! Topic: #Cirrhosis & #PortalHypertension Chair: Maria Papp 💡 Big moments: #AMMON-OHE model for post-#TIPS #encephalopathy (Rajiv Jalan) #Terlipressin response in AKI-HRS w/ CKD (Frank Uschner)

🩺 Impact of diabetes mellitus on clinical outcomes in patients with acutely decompensated cirrhosis #E_POSTER SAT-184-YI by Mimma Bonomo (UNITO) explores how coexisting diabetes mellitus affects prognosis in patients hospitalized with acute decompensation of cirrhosis. #EASL2025