Kiss, shrink, run | Science www.science.org/doi/10.1126/...

Kiss, Shrink, Run ⛹🏻‍♀️ New Perspective in @science.org about one of my favourite topics: how synapses and their tiny vesicles communicate in the brain. Chang-Lu Tao and colleagues reveal a previously unknown pathway for vesicle release. Read more here: doi.org/10.1126/scie... @istaresearch.bsky.social

We are delighted and very satisfied with a extremely smooth installation of the @abberior.rocks Mirava Polyscope, by 2 fantastic engineers. Our new ‘imaging soldier’ is equipped with 2- and 3D STED, MINDLUX, adaptive optics, lifetime imaging, matrix detectors and options for spectral imaging.

Doing a post doc

The @erc.europa.eu awards Advanced Grants to “active researchers who have a track-record of significant research achievements.” ISTA could now secure a quadruple success in the most recent call for these prestigious European grants. #ERCAdG

We just pushed “Memory by a 1000 rules” onto bioRxiv, where we use clever #ML to find #plasticity quadruplets (EE, EI, IE, II) that learn basic stability in spiking nets. Why is it cool? We find 1000s!! of solutions, and they don’t just stabilise. They #memorise! www.biorxiv.org/content/10.1...

Curious about the latest news on how RGP lineages generate cortical neuronal diversity? Don't miss our new review from @HippenmeyerLab written by @fabripipicelli.bsky.social and myself www.sciencedirect.com/science/arti...

www.sciencedirect.com/science/arti... Our new review in Current Opinion in Neurobiology is out! "How radial glia progenitor lineages generate cell-type diversity in the developing cerebral cortex"

🔬 Ever wondered how therapeutic antibodies work? 3D LLS-TDI-DNA-PAINT and live-cell LLS microscopy allow decoding of the molecular interplay of endogenous CD20 on B cells with therapeutic antibodies. 📄 Read more: www.science.org/doi/10.1126/...

New brain aging study is out today in Nature The largest single-cell RNA seq dataset of mouse brain aging reveals incredible insights and could pave the way for future therapies to slow or manage the impacts of the aging process. 🧵 #studyBRAIN

Human cortical pyramidal neurons are larger, with more elaborate branching, and distinct nonlinear biophysical properties compared to rat cortical pyramidal neurons. Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)

Researchers challenged longhorn crazy ants and humans with the same task: maneuvering a T-shaped object through two consecutive open doorways. Single humans always outperformed single ants, but ant groups could beat human groups. In PNAS: www.pnas.org/doi/10.1073/...

Delighted to highlight our new paper in @natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...

Axonal and synaptic mechanisms in the HUMAN neocortex that could underlie memory consolidation during slow-wave #sleep . Check out our latest research published today in Nature Communications ( @natureportfolio.bsky.social ). 🎉 Link: www.nature.com/articles/s41...

Want to know how many vesicles there are in a mossy fibre synapse, without counting thousands of vesicles by hand in electron micrographs? Our new tool SynapseNet has you covered and is now available as a preprint www.biorxiv.org/content/10.1... . Read on for a short overview of our paper.

Is neuroscience research really working to understand the human brain? Or do we get lost in mouse cognition? I’ve asked myself this a lot since starting to work with human tissue. Our first Jonas Lab foray into untangling human hippocampal circuits is now online! www.cell.com/cell/fulltex... 1/a few

Outstanding project by our lab and foremost by my super talented colleague @jakefwatson.bsky.social - check it out!!!