ACIP Day 1 is off and running. Before that gets in the weeds, check out my story from yesterday on the patchwork effort by states, coalitions and clinician groups to fill the void left by the CDC on vaccine guidance and outreach. endpoints.news/a-patchwork-...

Scoop: Covid-19 vaccine makers have been sidelined ahead of this week's ACIP meeting. Working group members have not asked companies to produce any data, though Pfizer had a call with members last week, per one source. For @endpts.com: endpoints.news/covid-19-vac...

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A 26-year-old collaboration between the government and top research centers to advance new pediatric brain cancer treatments is being wound down, an HHS spokesperson confirmed to @endpts.com. Money is being redirected to another childhood cancer funding channel. endpoints.news/hhs-winds-do...

HHS says ‘the science speaks for itself’ on mRNA cuts. Scientists it cites disagree Good piece from @maxbayer.bsky.social endpoints.news/researchers-...

HHS says that "the science speaks for itself" on the decision to retreat from mRNA vaccine research. But some of the scientists disagree. A team at @endpts.com reached out to co-authors behind 100+ studies cited by HHS and here's what we heard: endpoints.news/researchers-...

Scoop: An HHS official tasked with implementing MAHA's agenda was fired following BARDA's decision to cut 22 mRNA contracts. For @endpts.com: endpoints.news/hhs-official...

The first bit of detail I've seen on the cost of these Phase 4 studies strongly recommended by the FDA to Covid-19 vaccine makers. endpoints.news/novavax-expe...

FDA staff were overruled again by Vinay Prasad, who limited Moderna’s Covid vaccine to high-risk children under 12, arguing that healthy kids wouldn’t see sufficient clinical benefit.

Vinay Prasad overrode Covid vaccine reviewers for a third time when he approved Moderna's Covid vaccine for at-risk young kids. The company had applied for approval for all kids 6 months to 11 years old, though its unclear what exactly reviewers decided. endpoints.news/prasad-overr...

About 1 in 3 young people who are 12 to 17 years old have prediabetes, new national data show. www.statnews.com/2025/07/09/p...

Breaking: HHS Sec. Kennedy has adopted ACIP recommendations made in April, including for RSV vaccines. The recommendation for RSV expanded their use to at-risk 50-59 year olds. Updated meningococcal rec also adopted. www.cdc.gov/acip/vaccine...

Without even addressing the merits of that goal, why does disconnecting from left-wing groups mean tying yourself to right-wing messaging? Regardless of whether it's meant to be ironic, the people behind this are implicitly conceding that Project 2025 as a package was good communication strategy.

The FDA uploaded a number of new documents earlier this month involving Novavax's Covid-19 approval. New CBER chief Vinay Prasad wrote in a decisional memo that the harms of Covid vaccination may outweigh the benefits in "low-risk populations." endpoints.news/cber-chief-p...

ACIP voted to remove thimerosal from all flu vaccines, following a contentious debate between the rebuilt panel and clinicians. The sole former ACIP member on the new panel, Dr. Cody Meissner, was the only "no" vote. Our @endpts.com story: endpoints.news/cdc-vaccine-...

Our @endpts.com preview story ahead of this week's ACIP meeting. Politics and science are on a collision course, with the nation's vaccine guidance hanging in the balance. endpoints.news/politics-col...

punches

A remarkable few hours. Every ACIP member has been terminated. Many weren't notified before RFK's op-ed. Some are now receiving a succinct notice from CDC. Our @endpts.com story: endpoints.news/trump-admini...

We are a crossroads. CDC immunization schedule lists a shared clinical decision-making recommendation for healthy kids. But HHS reiterates in a statement to me that recommendations have been removed for that group and pregnant women.

Had the opportunity to chat with former senator Kyrsten Sinema about psychedelics and ibogaine. Really interesting to hear what's galvanized her and why she's specifically backing this drug. endpts.com/former-sen-k...

⚡ BREAKING: Summit says PD-1xVEGF bispecific ivonsecimab misses overall survival in closely-watched lung cancer study $SMMT endpts.com/summit-says-...

The NOTUS reporters said they spent five days (!) going through the 522 citations in the report.

Moderna's response to HHS saying that mRNA technology "remains under-tested" after axing funding for a bird flu vaccine: "Results during the pandemic speak for themselves, including demonstrated efficacy and a safety profile established in over a billion people worldwide."

Will Moderna's next-gen Covid vaccine be approved? I don't know! It very well might fit within the framework the FDA just put out. It's also technically the first "new" Covid vaccine in front of the FDA. I previewed the decision for @endpts.com. endpts.com/will-the-fda...

At the risk of sounding too horse race-y, Lykos' pain last year was Compass' gain in the race for the first FDA approved #psychedelic. My colleague Ayisha Sharma has a deeply reported story on the new frontrunner, and how commercial preparations are already underway. endpts.com/a-new-dawn-f...

The White House MAHA Commission is out with its first report. Here are my four takeaways for the drug industry: endpts.com/the-maha-rep...

Breaking: Marty Makary and Vinay Prasad spell out new FDA framework for future Covid vaccine approval in @nejm.org editorial. The two will elaborate at town hall later this afternoon. For @endpts.com: endpts.com/future-covid...

RFK has adopted updated ACIP guidance for the chikungunya vaccines but recommendations for RSV and meningococcal shots remain under review. For @endpts.com: endpts.com/kennedy-adop...

From deal to disaster: Drugmakers face a changed Washington as Trump embraces ‘most favored nation’ prices Good reporting from @maxbayer.bsky.social and @drewsnews.bsky.social: endpts.com/drugmakers-t...

An @endpts.com exclusive: President Trump met privately with Dave Ricks last Wednesday following a White House event with CEOs celebrating new US investments. But for the pharma industry, the party quickly ended. With @drewsnews.bsky.social endpts.com/drugmakers-t...

Our first @endpts.com Post-Hoc Live is in ***1 HOUR*** We'll be streaming on YouTube, LinkedIn and X. And there will be a replay available if you can't make it. If you tune in, give us feedback! We'll have a chat on the YouTube stream but you can also email us. www.youtube.com/live/RPsQ4DQ...

Here's something new: our first-ever Post-Hoc Live happens tomorrow at noon ET Watch @drewsnews.bsky.social, @maxbayer.bsky.social and @annajbrown.bsky.social talk pharma & tariffs — while live! endpts.com/how-pharma-i...

The biotech trade group BIO is out with a new campaign supporting vaccines: whywevaccinate.org

Breaking: FDA has asked Novavax to generate more clinical data in the form of a post-marketing commitment, further delaying approval. A company spokesperson wouldn't comment on timeline. endpts.com/fda-asks-nov...

@endpts.com got ahold of the HHS restructuring document. My angle this morning: endpts.com/cms-would-ab...

ACIP voted to expand RSV vaccine recommendations to at-risk adults in their 50s. That sound you hear is Moderna, Pfizer and GSK hootin and hollerin. But the recs still need CDC's stamp of approval, which is expected to come from RFK Jr. since there is no acting chief. endpts.com/cdc-advisors...

Pharma-specific tariffs inched closer after the Trump administration confirmed that it launched a 232 probe. That investigation actually began two weeks ago, on April 1. endpts.com/trump-drug-t...

Tomorrow is day 1 of the first ACIP meeting of 2025. I previewed the meeting and the status of the committee for @endpts.com. endpts.com/cdc-vaccine-...

We are accepting applications for Lawfare's paid Summer 2025 internship. The intern will assist with running and maintaining the Lawfare website and will have an opportunity to learn a variety of research skill. The application period will close on April 20. www.lawfaremedia.org/article/inte...

Q&A: Lundbeck’s head of R&D Johan Luthman on neuroscience strategy, the $2.6B seizure drug buyout, and what the BMS–Karuna deal means for Cobenfy.

@endpts.com breaking news: RFK will not testify before the Senate HELP committee this week. Senators had asked for an update on the restructuring effort. HHS was a no comment. endpts.com/rfk-wont-tes...

Reading Abundance is a major to-do so I'll tread lightly having not read the book yet. But this is answered somewhat in recent polling: Americans approve of DOGE's mission and hate its execution. I'd have questions for people who think not talking about bureaucracy is good, actually.

Scoop: HHS says in a memo to Capitol Hill that it will "streamline the FDA to remove unnecessary management layers and offices and streamline them into 5 shared services offices." More from the memo and an email to HHS staff about it in our @endpts.com story: endpts.com/fda-will-con...

My full @endpts.com Q&A with BIO CEO John Crowley, covering tariffs, layoffs, MAHA and US manufacturing. A confluence of obstacles has him concerned that the industry is "dangerously close" to breaking. But he's confident the admin wants to support biotech's core mission. endpts.com/bio-ceo-on-t...

@endpts.com had the first interview with BIO CEO John Crowley after large-scale cuts swept across the FDA. “It’ll be a challenge,” he said today. “We take the FDA as we find it and this is the FDA we have today.” More on the cuts, on Peter Marks, on moving forward: endpts.com/itll-be-a-ch...

An @endpts.com exclusive: Transcend Therapeutics succeeds in a Phase 2 study testing its neuroplastogen treatment for PTSD. endpts.com/transcends-n...

Lykos’ interim CEO, Michael Mullette, is set to step down @maxbayer.bsky.social for Endpoints. endpts.com/lykos-interi...

SCOOP: NIH abruptly canceled a slew of #LongCOVID studies funded through its RECOVER initiative this week, including 45 pathobiology studies designed to uncover how the disease works inside the body. @cenmag.bsky.social #chemsky #biosky cen.acs.org/policy/resea...

10,000 job cuts hitting HHS as part of a gigantic agency reorg. @zacharybrennan.bsky.social has the breaking news: endpts.com/hhs-plans-to...