WORMoholic
@karoatarlab.com
📤 654
📥 326
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We are all about immunology, host-helminth interactions and tissue regeneration. karoatarlab.com
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WORMoholic
Henry McSorley
about 2 months ago
Latest McSorley lab paper is out! Led by Vivien
@vshek.bsky.social
, this is a story about the immunomodulators from H. polygyrus bakeri (Hpb), and how their analysis led to the identification of HpBoRB, a secreted protein which binds host RELM-beta
www.sciencedirect.com/science/arti...
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WORMoholic
Ariel Munitz
4 months ago
Just published in @AllergyEaaci Led by @dsilvaanish66 in collaboration with @RothenbergLab @ChenVarol @AstraZeneca. We reveal a non-redundant and key role for TSLP in eosinophilic esophagitis (EoE)- a chronic allergic disease of the esophagus.
onlinelibrary.wiley.com/doi/10.1111/...
🧵👇 1/8
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https://onlinelibrary.wiley.com/doi/10.1111/all.16682
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WORMoholic
Andrew S. MacDonald
4 months ago
Great to be a (small) part of this beautiful new study on global diversity of soil transmitted
#helminths
from
@stephenrdoyle.bsky.social
and colleagues 🧪
www.nature.com/articles/s41...
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Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets - Nature Communications
This study analysed genetic data of soil-transmitted helminths from 27 countries, revealing diversity impacting molecular test accuracy and highlighting the need to adapt diagnostics for effective STH...
https://www.nature.com/articles/s41467-025-61687-0
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WORMoholic
Henry McSorley
6 months ago
🚨 New McSorley lab paper just out in Cell Reports! Very happy to see this published - it has been a lot of work, and its turned into a really nice story. In it, we show that HpARI+HpBARI can be used as vaccines Tutorial thread below (1/16):
www.sciencedirect.com/science/arti...
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Vaccination against helminth IL-33 modulators permits immune-mediated parasite ejection
The murine intestinal nematode Heligmosomoides polygyrus bakeri (Hpb) modulates the host immune response via the Hpb alarmin release inhibitor (HpARI)…
https://www.sciencedirect.com/science/article/pii/S2211124725004929
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WORMoholic
SusanWestfall
7 months ago
Take a look at our latest work from
@ikinglab.bsky.social
identifying an immune-stromal cell axis that mediates disease tolerance against intestinal infection. It's been a pleasure working with a truly collaborative team to make this project a reality.
authors.elsevier.com/c/1kznjL7PXu...
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https://authors.elsevier.com/c/1kznjL7PXuEcm
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WORMoholic
King Lab at McGill University
7 months ago
I am very excited to share our article on IFNg, stroma and disease tolerance during intestinal helminth infection published today in Cell. This work was lead by the amazing
@susanwestfall.bsky.social
and supported by many international collaborators.
www.sciencedirect.com/science/arti...
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A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection
Type 1 immunity mediates host defense through pathogen elimination, but whether this pathway also impacts tissue function is unknown. Here, we demonst…
https://www.sciencedirect.com/science/article/pii/S0092867425003952?dgcid=coauthor
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A protective role for IFN-gamma during helminth infections—gotta love it! Congrats
@ikinglab.bsky.social
and
@susanwestfall.bsky.social
Really beautiful work, thank you for letting me be a small part of it
#Medsky
#immunosky
🪱
authors.elsevier.com/c/1kznjL7PXu...
7 months ago
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WORMoholic
Shai Bel (The Mucus Man)
7 months ago
🚨🚨 Dear friends in North America: I will be taking a 1-year sabbatical at
@uwmadisonmmi.bsky.social
with the wonderful
@markjmandel.bsky.social
(bringing the
#mucus
back to the marine world) from August 2025. If you want to meet up, let me know! Please share
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Eduardo Villablanca
7 months ago
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis Immunity
www.cell.com/immunity/ful...
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Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis
Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis. IL-22 production by group 3 innate lymphoid cells (I...
https://www.cell.com/immunity/fulltext/S1074-7613%2825%2900136-0
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WORMoholic
Mucosal Immunology
7 months ago
The microbiota regulates intestinal goblet cell response and mucin production during enteric parasitic infection via the TLR2-SPDEF axis
www.mucosalimmunology.org/article/S193...
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So cool
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8 months ago
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We have a new baby! We are going to have some beautiful images soon 🪱🔬🧪
8 months ago
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Ariel Munitz
9 months ago
Preprint 📢📢 Epithelial cell-derived cytokines such as TSLP snd IL-33 likely have key roles in the initiation of allergic diseases. We show that despite co-upregulation/expression of IL-33 and TSLP in EoE, TSLP has a dominant role.
www.biorxiv.org/content/10.1...
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Distinct roles for thymic stromal lymphopoietin (TSLP) and IL-33 in experimental eosinophilic esophagitis
Rationale: Thymic stromal lymphopoietin (TSLP) and IL-33 are alarmins implicated in EoE pathogenesis by activating multiple cells including mast cells (MCs). Whether TSLP or IL-33 have a role in EoE a...
https://www.biorxiv.org/content/10.1101/2025.02.25.640192v1
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Help a new PI! Started working on my first Intro to Immunology course lectures. Any suggestions on the best story/ historic perspective to make my students LOVE immunology above all? Jenner and Pasteur are the obvious fathers but maybe someone found another intriguing option?
#Immunosky
🧪
9 months ago
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WORMoholic
European Research Council (ERC)
9 months ago
Hello, Bluesky! ☀️ We fund frontier research in Europe—bold ideas, unexpected discoveries and science that shapes the future. So it’s only fitting we’ve landed here. Sorry for being late. Follow us for updates on ERC funding, research policy, and our grantees' discoveries.
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Sarah Ross
11 months ago
#Immunology
by First release now
@science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection
https://buff.ly/3DjNQ1e
By Maria Canesso,
@danmucida.bsky.social
,
@victora.bsky.social
and colleagues.
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🤯
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11 months ago
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Interesting!
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11 months ago
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Open minds and close friends is always important, science is no exception 🧪
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11 months ago
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WORMoholic
Mike Schumacher
12 months ago
We know everything about IL-33 already, right? No! In fact we know very little about IL-33 in the colonic epithelium Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵
www.mucosalimmunology.org/article/S193...
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When a fungal commensal ruins over a year of your postdoc at least you get a chance to be part of a very cool paper. Was great to be included in this interesting story 🧪 🪱🍄🟫
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12 months ago
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WORMoholic
TRAstonDrs
12 months ago
#MedSky🧪
#ImmunoSky
#IDsky
#academicsky
#publichealth
An excellent
#Clinicalperspectives
of The “danger theory of immunity” ,Immunogenetics of danger signals & Nuancing the danger theory of immunity
www.nature.com/articles/s41...
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Beautiful
add a skeleton here at some point
12 months ago
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WORMoholic
Barral Lab
12 months ago
Our first 🦋 post! Very happy to share our latest paper just out in Cell Reports, exploring the crosstalk between immune and epithelial cells in the gut. Check it out!
@vivianlilab.bsky.social
@kingscollegelondon.bsky.social
www.cell.com/cell-reports...
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IFN-γ-dependent regulation of intestinal epithelial homeostasis by NKT cells
The crosstalk between immune and epithelial cells is vital to maintain intestinal homeostasis. Lebrusant-Fernandez et al. identify NKT cells in the small intestine as key regulators of epithelial biol...
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01299-3
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Tara Sutherland
about 1 year ago
My lab in Aberdeen, in the stunning North East of Scotland, will soon be recruiting for a post-doc to studying immune-ECM interactions in the lung. If you love IL-13, Hyaluronan, ECM biology, pulmonary immune responses....Get in touch and keep an eye out for the position.
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Such a cool paper!
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about 1 year ago
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WORMoholic
Gal Haimovich ☣ 🧪🔬🎗
about 1 year ago
בדיוק פורסם מחקר חדש של שי בל (פקולטה לרפואה בצפת), שמראה שאנטיביוטיקה משפיעה ישירות על תאים מפרישי ריר במעי ועלולה לגרום לתופעת מעי רגיז. השוס כאן הוא שאין לזה קשר בכלל למיקרוביום של במעי.
www.science.org/doi/10.1126/...
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WORMoholic
Andrew S. MacDonald
about 1 year ago
I'm looking for 2 Postdocs & a Technician to join my team in Edinburgh, investigating
#mucosal
#immunity
&
#inflammation
during
#schistosome
#infection
. If this sounds exciting to you, pls apply! (by 19th Sep)🪱🔬🏴
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
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Postdoctoral Research Associate
We are looking for a Postdoctoral Research Associate to investigate the mucosal immune and inflammatory response during murine infection with the parasite Schistosoma mansoni, focusing on refined cell...
https://elxw.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1001/job/11136
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WORMoholic
Dor Salomon
about 1 year ago
Our observation piece is now online in Microbiology Spectrum: "Bile acids activate the antibacterial T6SS1 in the gut pathogen Vibrio parahaemolyticus" 🦠
journals.asm.org/doi/10.1128/...
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Bile acids activate the antibacterial T6SS1 in the gut pathogen Vibrio parahaemolyticus | Microbiology Spectrum
Bacterial pathogens often manipulate their host and cause disease by secreting toxic proteins. However, to successfully colonize a host, they must also remove commensal bacteria that reside in it and ...
https://journals.asm.org/doi/10.1128/spectrum.01181-24
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Next Gen tissue histology, might be fun to try!
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over 1 year ago
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WORMoholic
Dor Salomon
over 1 year ago
New dates for ISM2024 meeting are September 9-10, 2024. To register and submit an abstract (more than half the talks are selected from the abstracts) visit
ism.org.il/annualmeeting
🦠
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I think it's appropriate to start my Bluesky feed with the first Karo-Atar lab organoid culture! It took 6 months but we have (almost) everything we need to start doing some exciting research!!!🪱🪱 Let the fun begin 🤭
almost 2 years ago
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