@rosellilab.bsky.social
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Open position for graduate student at the Roselli lab!
8 months ago
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To all colleagues here: have you ever built your own hardware upgrades, and is it worth compared to buying it?
8 months ago
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A new preprint from the lab: are there actionable entry points to treat intracranial hypertension? our investigation of a porcine subdural haematoma model:
www.biorxiv.org/content/10.1...
9 months ago
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reposted by
Jonathan Kipnis
10 months ago
Excited to share our work by exceptional postdoc, Kyungdeok (KD) Kim. 2025 marks 10th anniversary of meningeal lymphatic discovery and I canât be happier celebrating it with this work addressing how lymphatic dysfunction leads to cognitive deficits ||
www.sciencedirect.com/science/arti...
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Meningeal lymphatics-microglia axis regulates synaptic physiology
Meningeal lymphatics serve as an outlet for cerebrospinal fluid, and their dysfunction is associated with various neurodegenerative conditions. PrevioâŠ
https://www.sciencedirect.com/science/article/pii/S0092867425002107
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Heading to the Mario Negri Institute in Milan! New TBI research will be presented in our talk there tomorrow!
11 months ago
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reposted by
Max-Planck-Gesellschaft
11 months ago
New treatment avenue for
#Duchenne
muscular dystrophy: researchers found that transcriptional adaptation can boost utrophin production in human cells, unlocking a promising new therapeutic approach!đ@stainierlab.bsky.socialâŹ, Lara Falcucci,
@cmdooley.bsky.social
,
@douglasadamoski.bsky.social
et al.
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Mechanism for treating muscle degeneration discovered
Utrophin increase in muscle cells after transcriptional adaptation normalises cell function in Duchenne muscular dystrophy
https://www.mpg.de/24166261/0212-pfor-mechanism-for-treating-muscle-wasting-discovered-149770-x?c=2249
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reposted by
Nature
11 months ago
CAR-T-cell therapy treated a girl with a rare childhood cancer, raising hopes for future recipients of the approach
https://go.nature.com/42XLYpK
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Woman in cancer remission for record 19 years after CAR-T immune treatment
CAR-T-cell therapy treated a girl with a rare childhood cancer, raising hopes for future recipients of the approach.
https://go.nature.com/42XLYpK
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A new collaborative paper is out... a surprising new non-conventional phenotype in ALS, and a way to treat it:
www.science.org/doi/10.1126/...
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Early-onset sleep alterations found in patients with amyotrophic lateral sclerosis are ameliorated by orexin antagonist in mouse models
In amyotrophic lateral sclerosis, sleep defects occur in patients, risk gene carriers, and mouse models in which they are rescued preclinically by an orexin antagonist.
https://www.science.org/doi/10.1126/scitranslmed.adm7580
12 months ago
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We are glad to celebrate our associate Florian olde Heuvel, for the award of the Hannelore Kohl Foundation national prize for his work on biomarkers of synaptic damage in human severe TBI !
jnnp.bmj.com/content/95/1...
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Dynamics of synaptic damage in severe traumatic brain injury revealed by cerebrospinal fluid SNAP-25 and VILIP-1
Background Biomarkers of neuronal, glial cells and inflammation in traumatic brain injury (TBI) are available but they do not specifically reflect the damage to synapses, which represent the bulk volu...
https://jnnp.bmj.com/content/95/12/1158.long
12 months ago
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reposted by
Computational Systems Neuroscience
about 1 year ago
--- Seminar in
#Neuroscience
--- Functional diversity of inhibitory amygdala microcircuits đŁ Dr. Sabine Krabbe, DZNE, Bonn đ Jan 27, 2025 - 16:00 Lecture Hall, Biocenter
@unicologne.bsky.social
zoologie.uni-koeln.de/forschung/ne...
@ibehave.bsky.social
@ggatto.bsky.social
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Some more recent work in preprint format (we really like preprinting everything!) :
www.biorxiv.org/content/10.1...
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Spinal motoneuron excitability is homeostatically-regulated through ÎČ-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice
Homeostatic feedback loops are essential to stabilize the activity of neurons and neuronal networks. It has been hypothesized that, in the context of Amyotrophic Lateral Sclerosis (ALS), an excessive ...
https://www.biorxiv.org/content/10.1101/2024.03.25.586570v3
about 1 year ago
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A very productive collaboration with the always-great Beato lab!
www.cell.com/cell-reports...
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Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration
Through in vitro and in vivo electrophysiology and super-resolution microscopy, Nascimento et al. identify early-stage alterations in pre-motor spinal recurrent inhibition and monosynaptic Ia excitati...
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01397-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124724013974%3Fshowall%3Dtrue
about 1 year ago
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More neuropathology forays for us, and third paper with the Braaks :
actaneurocomms.biomedcentral.com/articles/10....
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Patterns of synaptic loss in human amyotrophic lateral sclerosis spinal cord: a clinicopathological study - Acta Neuropathologica Communications
Amyotrophic Lateral Sclerosis (ALS) is mainly characterized by the degeneration of corticospinal neurons and spinal α-motoneurons; vulnerable cells display prominent pTDP-43 inclusions. Evidence gathe...
https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-023-01616-8
about 1 year ago
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Forays into human neuropathology and the mistery of white-matter neurons (with the living legends Braak&delTredici):
actaneurocomms.biomedcentral.com/articles/10....
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Neuropeptide FF (NPFF)-positive nerve cells of the human cerebral cortex and white matter in controls, selected neurodegenerative diseases, and schizophrenia - Acta Neuropathologica Communications
We quantified and determined for the first time the distribution pattern of the neuropeptide NPFF in the human cerebral cortex and subjacent white matter. To do so, we studied nâ=â9 cases without neur...
https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-024-01792-1
about 1 year ago
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Highlights from the last three months of RoselliLab work! Marker of synaptic damage and neuroinflammation in human severe TBI
pmc.ncbi.nlm.nih.gov/articles/PMC...
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Dynamics of synaptic damage in severe traumatic brain injury revealed by cerebrospinal fluid SNAP-25 and VILIP-1
Biomarkers of neuronal, glial cells and inflammation in traumatic brain injury (TBI) are available but they do not specifically reflect the damage to synapses, which represent the bulk volume of the b...
https://pmc.ncbi.nlm.nih.gov/articles/PMC11671962/
about 1 year ago
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Blood-CSF barrier in ALS: patterns and alterations across >1000 patients
academic.oup.com/brain/articl...
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BloodâCSF barrier integrity in amyotrophic lateral sclerosis
The bloodâCSF barrier helps to regulate inflammation in the CNS, and to shield the CNS from potentially toxic external factors. Klose et al. show that the
https://academic.oup.com/brain/article-abstract/147/12/4254/7672885?redirectedFrom=fulltext&login=false
about 1 year ago
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Hypothalamic atrophy as a new imaging endophenotype in ALS: how does it change in ALS variants?
www.nature.com/articles/s41...
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Hypothalamic atrophy in primary lateral sclerosis, assessed by convolutional neural network-based automatic segmentation - Scientific Reports
Scientific Reports - Hypothalamic atrophy in primary lateral sclerosis, assessed by convolutional neural network-based automatic segmentation
https://www.nature.com/articles/s41598-025-85786-6
about 1 year ago
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A good start into 2025 for the RoselliLab. A refined MR spectroscopy pipeline for the definition of absolute metabolite concentration in the mouse brain with sub-microliter spatial resolution:
onlinelibrary.wiley.com/doi/10.1111/...
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SubâMicroliter 1H Magnetic Resonance Spectroscopy for In Vivo HighâSpatial Resolution Metabolite Quantification in the Mouse Brain
An optimized acquisition and post-processing pipeline for brain magnetic resonance spectroscopy based on the LASER sequence is reported, enabling metabolite spectra from 700ânL volume of interest in ...
https://onlinelibrary.wiley.com/doi/10.1111/jnc.16303
about 1 year ago
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Here comes the RoselliLab also on BlueSky !
about 1 year ago
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