On Halloween, I recommend reading Anthony' Petrosino's appreciation of statistician Fred Mosteller, including how Fred invoked #Halloween in providing comments on one of his draft articles 👇 www.jameslindlibrary.org/articles/cha...

On #WorldStrokeDay (www.world-stroke.org/world-stroke...), learn about the disconnect between pre-clinical and clinical research and the role of CAMARADES in this article that Merel Ritskes-Hoitinga and Pandora Pound wrote for me 👇 www.jameslindlibrary.org/articles/the... #EBM #EBHC

Remind yourself of the value of the randomised trial on #WorldPolioDay through a history of the Salk #polio vaccine trial, which showed the vaccine's benefits 50 years ago journals.sagepub.com/doi/10.1177/... Read more by Harry Marks in my library www.jameslindlibrary.org www.who.int/europe/campa...

Ahoy! If you would like to see some other articles that illustrate the recent history of individual participant data meta-analyses, click on this link www.jameslindlibrary.org?s=individual and scroll down through my records.

On #WorldSightDay learn about the development of fair tests of treatment though history in the late Bill Silverman's reflections on his 1950s randomised trial of using adrenocorticotropic hormone for retinopathy of prematurity 👇 www.jameslindlibrary.org/articles/per... #LoveYourEyes #RCT #EBM #EBHC

Ahoy! You can learn more about the history of systematic reviews and meta-analysis in the article that Mike Clarke wrote for me in 2015 www.jameslindlibrary.org/articles/his... #EvidenceSynthesis #EBM #EBHC

Marking the sad news of Drummond Rennie's death, a tribute has been added here www.jameslindlibrary.org/flanagin-a-g... Also, Drummond and Iain Chalmers wrote about the dangers of medical reviews and textbooks that ignore scientific principles here www.jameslindlibrary.org/articles/exp... @jama.com

If you'd like to learn about the development of randomised trials in education through history, read my new article from Carole Torgerson about the first use of randomisation in educational research www.jameslindlibrary.org/articles/whe... #RCT #FairTests #EducationalResearch #History #Randomized

100 years ago today, the British Medical Journal published Moir's study of the narcotic effects of two hyoscines using alternation to form comparable groups. It's at www.jameslindlibrary.org/moir-jc-1925 illustrating the development of fair tests of treatment through history @bmj.com

Ahoy! If you'd like to watch an interview between Cindy and Iain Chalmers recorded about 30 years ago, it starts 1:38 into the video at radar.brookes.ac.uk/radar/items/...

Ahoy! You might also be interested in reading the piece Dave Sackett wrote for me about why he became a clinician trialist. It's available free here: www.jameslindlibrary.org/articles/why... #RandomizedTrials #DaveSackett #EBM

Read the new commentary that Christian Gluud and Kristian Thorlund wrote for me about Klim McPherson’s article on sequential analysis of trial data, which was published more than half a century (51 years) ago www.jameslindlibrary.org/articles/lon... #TSA #TrialSequentialAnalysis #RCT

On World Mosquito Day (www.worldmosquitoprogram.org/world-mosqui...), what better way to learn about clinical trials through history than reading the article Silvio Garattini wrote for me about early 20th century controlled trials to prevent malaria in Italy www.jameslindlibrary.org/articles/ita...

Ahoy! With the publication of the new SPIRIT guidance on reporting protocols for randomised trials, read about the history of reporting guidelines in the article that Doug Altman and Iveta Simera wrote for me in 2015 www.jameslindlibrary.org/articles/a-h... #SPIRIT #RCT @equatornetwork.bsky.social‬

Ahoy! 40 years since #BackToTheFuture, use the James Lind Library to learn about randomised trials through history, including 1985 trial from the #WHO testing coronary heart disease prevention in 50,000 men from 66 factories in Belgium, Italy, Poland & UK www.jameslindlibrary.org/kornitzer-m-...

On #International#PineappleDay www.nationaldaycalendar.com/internationa... have a look at my record for a @jama.com article from 99 years ago in which George Minot & William Murphy describe a diet (that included #pineapple) for treating pernicious anaemia www.jameslindlibrary.org/minot-gr-mur...

On #Red4Research Day, visit my website at JamesLindLibrary.org to learn about the development of fair tests of treatment through history

1/3 On Friday 13th, here's some things you might like to read about the effects of chance in research.... #FridayThe13th #FairTests

Following the discovery of papers showing Churchill's concerns about the availability of #penicillin during WW2 www.bbc.com/news/article..., read the article Ben Toth wrote for me about some of the research that showed the drug's remarkable benefits www.jameslindlibrary.org/articles/pio... #BBC #WW2

On #WorldBicycleDay (www.un.org/en/observanc...), have a look at this trial from 50 years ago (yes, half a century!) that randomised participants to a control group or 20 weeks of running, walking or cycling for 30 minutes three times a week pubmed.ncbi.nlm.nih.gov/1152627/ #Exercise #RCT

#TrialsTuesday #9 In recent weeks, Trials Tuesday has highlighted some small, practice changing trials. In contrast, today’s trial is one that was described as “massive” by Keith Veronese in Making Medicine. It was called ISIS-2. 1/8

Ahoy! Congratulations to DAMOCLES on its 20th anniversary. Peter Armitage reflected on earlier years of data monitoring committees in his interview with Iain Chalmers: www.jameslindlibrary.org/articles/the... Another example of seeing the development of fair tests of treatment through history

#TrialsTuesday #8 1/8 On #InternationalClinicalTrialsDay 2025, we feature STAMPEDE, a trial that started in 2005 and announced its first practice changing results 10 years ago today, to the American Society of Oncology ascopubs.org/doi/10.1200/... @ascocancer.bsky.social‬ @mrcctu.bsky.social‬

Welcome to the James Lind Library, illustrating the development of fair tests of treatments through history. We have more than 1200 primary historical Records, 280 Articles, and multilingual Essays, along with podcasts, videos and quizzes. All content is free at www.jameslindlibrary.org

On International Clinical Trials Day, you can learn more about me and what I achieved in the article that was written by Iain Milne www.jameslindlibrary.org/articles/who... #InternationalClinicalTrialsDay #BePartOfResearch

#TrialsTuesday #7. Today, I’ll take you more than 100 years further back in time than my trial of scurvy. I’ll share with you a proposal for a study that highlighted the need for fair tests when a common treatment might do more harm than good #FairTest #TestingTreatments 1/8

May 13 2025: 10th anniversary of death of Dave Sackett. Read extended questions & answers he prepared shortly before his death to describe his multiple careers, importance of fair tests and evidence-based medicine www.jameslindlibrary.org/sackett-dl-2... @cebmoxford.bsky.social #EBM #EBHC #Cochrane

Ahoy! Read more about the benefits of trial registration in my article by Kay Dickersin and Iain Chalmers, including their discussion of John Simes' 1986 call for an international registry of clinical trials www.jameslindlibrary.org/articles/rec... Simes 1986: www.jameslindlibrary.org/simes-rj-1986/

#TrialsTuesday #6 Harry Gold, featured in the last #TrialsTuesday for his work on double blind trials of angina. Another important trial for this condition tested a surgical procedure, internal mammary artery ligation, by comparing it to “sham surgery” 1/8

On #WorldMalariaDay visit my website to learn about the use of fair tests to identify effective treatments through history, including a recent article discussing artemisinin (Qinghaosu) as part of the history of trials in #China www.jameslindlibrary.org/articles/the... www.who.int/campaigns/wo...

Ahoy! Want to learn more about blinded outcome assessment through history? Read my essay at www.jameslindlibrary.org/essays-essay... #DoubleBlind #EBHC #EBM #RCT #FairTests

#TrialsTuesday #5. Gold featured as an ineffective treatment for tuberculosis in the last TrialsTuesday. This week, I feature a person who shares the name of the element - Harry Gold – and the history of the "double blind" trial 1/8 #DoubleBlind

Ahoy! If you want to get on board with some other articles about spin, I have some relevant records at www.jameslindlibrary.org?s=spin #Spin #Bias

#TrialsTuesday #4 Last week’s TrialsTuesday was the MRC trial of streptomycin for TB which used random numbers to fill envelopes that, when opened, revealed a patient’s assigned treatment. But, what about using a more familiar method for using chance to choose between options: flipping a coin? 1/8

On World Parkinson's Day, you can read my article about the use of placebos in surgical trials, including those for people with Parkinson’s disease www.jameslindlibrary.org/articles/use... worldparkinsonsday.com @parkinsonseurope.bsky.social #WorldParkinsonsDay

TrialsTuesday #3 Last #TrialsTuesday, I featured the #MRC 1994 trial showing that patulin was not effective for treating the common cold. Today, it’s a more famous MRC trial from the same decade: streptomycin for pulmonary tuberculosis, published in the BMJ on 30 October 1948 1/8 @bmj.com

#TrialsTuesday #2 Last week, I reminded you of my trial of oranges and lemons for scurvy. This week it’s apples, or more precisely a substance from a mould that grows on apples, and testing it as a treatment for the common cold. It’s the Medical Research Council’s 1944 trial of patulin 1/8

1/2 I'm delighted to learn from the #BBC that the pioneering Dame Louise McIlroy, first female professor of medicine in Britain and Ireland is to be honoured in her home town in County Antrim www.bbc.com/news/article...

Learn more about the history of ISIS-2 in the article #RichardPeto wrote for me about his reflections on the design and analysis of clinical trials and meta-analyses in the 1970s and 1980s www.jameslindlibrary.org/articles/ref... #RCT #EBHC #EBM

#TrialsTuesday #1 Starting today, every Tuesday here in Bluesky, I’ll tell you about an important clinical trial. Where better to begin than with my own study of treatments for scurvy on board the gun ship, Salisbury 1/8

If you would like to learn about the history of the RECOVERY trial, read the article that Paul Glasziou and Kao Tikkinen wrote for me www.jameslindlibrary.org/articles/the... @paulglasziou.bsky.social #EBM #COVID-19 #RECOVERY

Ahoy!If you'd like to read more from Dave Sackett, try the article he wrote for me in 2015 about why he became a clinical trialist www.jameslindlibrary.org/articles/why...

I agree Jaribio. Anyone wanting to learn about randomised trials through history can access ship loads of information at www.jameslindlibrary.org #RCT #JamesLind

On this, the 51st anniversary of its publication, I am pleased to point you to my record for Klim McPherson's 1974 comments about the problem of examining a clinical trial's accumulating data more than once www.jameslindlibrary.org/mcpherson-k-... #RCT #TrialSequentialAnalysis #EBM #EBHC #Statistics

Hail and well met! Changing ships mid voyage is always tricky. We are moving here from X, like everyone else. I was lucky to have three different ships in which to compare the effects of treatments for scurvy. I will be posting about the history of fair tests of treatments. jameslindlibrary.org