David Harrison
@davidaharrison.bsky.social
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Co-Director of ICNARC. Honorary Professor of medical statistics at LSHTM.
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David Harrison
Segun Olusanya
7 days ago
Fantastic to see this published at last An objective assessment of the efficacy of home pulse oximeters on different skin tones Ping
@iwashyna.bsky.social
Open to comments from all
#foamed
#medsky
www.bmj.com/content/392/...
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The impact of skin tone on performance of pulse oximeters used by NHS England COVID Oximetry {at}home scheme: measurement and diagnostic accuracy study
Objectives To assess the impact of skin tone on the measurement and diagnostic accuracy of five fingertip pulse oximeters used by patients in the NHS (National Health Service) England COVID Oximetry {...
https://www.bmj.com/content/392/bmj-2025-085535
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David Harrison
Critical Care Reviews
28 days ago
🎄 On the fourth day of Christmas CCR brings to thee 🎁 Four thousand seven hundred children 🎅 No routine gastric residuals measured routinely 🎶 And a partridge in a pear tree
#CCR26
criticalcarereviews.com/meetings/ccr26
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David Harrison
Emma Vardy
2 months ago
Delighted to share details of
@nihr.bsky.social
James Lind Alliance research priority setting survey for delirium. For completion by UK health/social professionals and those with personal experience of delirium. Complete the survey and have your say. More details 👇
www.qmul.ac.uk/wiph/centres...
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A Delirium (UK) James Lind Alliance Priority Setting Partnership - Wolfson Institute of Population Health
https://www.qmul.ac.uk/wiph/centres/centre-for-psychiatry-and-mental-health/james-lind-alliance-survey-/
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David Harrison
Alex Warren
7 months ago
16,500 patients randomised to
#UKROXTrial
presented just now at
#CCR25
and simultaneously published in
@jama.com
No difference in 90d mortality between target SpO2 88-92 with reduced exposure to supplemental O2 vs usual care
jamanetwork.com/journals/jam...
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Conservative Oxygen Therapy With Mechanical Ventilation
This randomized clinical trial assesses whether reducing supplemental oxygen to a peripheral oxygen saturation target of 90% would reduce mortality among critically ill adults receiving mechanical ven...
https://jamanetwork.com/journals/jama/fullarticle/2835384?utm_source=jamanetwork.com
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David Harrison
Mark Peters
7 months ago
UK-ROx: No harm (or benefit) from a conservative oxygenation strategy in 16,500 mechanically ventilated critically ill adults.
#CCR25
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David Harrison
JAMA
7 months ago
Conservative oxygen therapy with a target SpO2 of 90% did not reduce 90-day all-cause mortality compared to usual oxygen therapy in mechanically ventilated adult patients. #CCR25 @criticalcarereviews.com
https://ja.ma/4kG5gWK
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Here we go…
#UKROXtrial
#CCR25
7 months ago
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David Harrison
THIS Institute (The Healthcare Improvement Studies Institute)
8 months ago
Calling all UK-based healthcare professionals who have undertaken a quality improvement project! Share your experiences with us and help us to develop new approaches. Certificates of participation offered. Find out more and fill out the short survey
ths.im/3SUUwHG
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David Harrison
Critical Care Reviews
8 months ago
🚨UK-ROX TRIAL Results at
#CCR25🚨
📍 ~100 🇬🇧 ICUs 👥 ~16,500 pts 🎯 Conservative vs usual oxygen therapy in invasively ventilated adults 🩺 Outcome: Mortality day 90 🤔 Will less oxygen save lives? 📺 Free livestream — but it's better in person! 🔗
criticalcarereviews.com/ccr25
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David Harrison
Intensive Care Society
8 months ago
The Society and the Faculty of Intensive Care Medicine (FICM) are updating the Guidelines for the Provision of Intensive Care Services (GPICS). The consultation period for Version 3 is now open and we would value your feedback on the proposed changes. Read more and take part below👇
bit.ly/GPICSv3
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Shocked to wake up to this news. Condolences to Rinaldo’s family and friends, and all our friends and colleagues in the ANZICS community. Vale Rinaldo.
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9 months ago
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David Harrison
WHO
9 months ago
It’s
#WorldImmunizationWeek
Vaccines have saved 154 million lives in the last 50 years. That’s 6 lives every minute. A reminder of what is
#HumanlyPossible
. Science saves lives.
#VaccinesWork
bit.ly/wiw2025
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David Harrison
MRC Clinical Trials Unit at UCL
9 months ago
People who take part in
#ClinicalTrials
and other research have a right to know the results of these studies. Our 8 principles aim to improve the sharing of trial results with participants. They were developed alongside UK clinical research funders. More details👉
buff.ly/SGrmL7o
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David Harrison
11 months ago
Invitation to a Two-Round Delphi Study on Sample Size Reporting in Trial Grant Applications and Protocols for Adaptive Designs! Click the link below to participate 👏:
docs.google.com/forms/d/e/1F...
Or directly contact:
[email protected]
.
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reposted by
David Harrison
Hetan Shah
about 1 year ago
I'm honoured to have been asked to give this year's
@healthfoundation.bsky.social
annual REAL Challenge lecture - on the theme of AI and health. Thursday 13th Feb in person / online. You can register here and please do share with any networks that may be interested
www.health.org.uk/events/hype-...
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Hype, hallucination, hope – what might AI mean for our health?
In our fifth REAL Challenge annual lecture, Hetan Shah will warn of the risk of rushing breathlessly to unleash technology. He will explore how policymakers can navigate the hype and critically assess...
https://www.health.org.uk/events/hype-hallucination-hope-what-might-ai-mean-for-our-health
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David Harrison
Royal College of Anaesthetists
12 months ago
The College is seeking applications for the position of Director of our Centre for Research and Improvement, which oversees delivery of all College research projects. An exciting opportunity to play a vital role in our research and improvement work.
ow.ly/A47350UQfxx
@rcoa-cri.bsky.social
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reposted by
David Harrison
Mark Peters
about 1 year ago
Post-hoc analysis of Oxy-PICU by baseline severity of gas exchange - no detectable heterogeneity of treatment effect.
journals.lww.com/pccmjournal/...
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Severity of Impaired Oxygenation and Conservative... : Pediatric Critical Care Medicine
2% was associated with a shorter duration of organ support and greater survival, compared with Spo2 greater than 94%, in mechanically ventilated children following unplanned admission to PICU. We inve...
https://journals.lww.com/pccmjournal/fulltext/9900/severity_of_impaired_oxygenation_and_conservative.425.aspx
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reposted by
David Harrison
Mark Peters
about 1 year ago
1 year follow-up and health economics of Oxy-PICU. All point estimates still favour conservative oxygenation but differences are not statistically significant with the slightly smaller sample size.
www.sciencedirect.com/science/arti...
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Longer-term survival, quality of life, and cost-effectiveness of conservative versus liberal oxygenation targets in critically ill children: a pre-specified analysis from Oxy-PICU, a multicentre, open...
Peripheral oxygen saturation (SpO2) above 94% is typical in children in paediatric intensive critical care units (PICUs) who are receiving invasive ve…
https://www.sciencedirect.com/science/article/pii/S2352464224002943
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David Harrison
Critical Care Reviews
about 1 year ago
The third trial result for
#CCR25
in Titanic Belfast in June is the UK-Rox Trial Evaluating the clinical & cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in ICU Register via the QR code or on the CCR website
criticalcarereviews.com/meetings/ccr25
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reposted by
David Harrison
Critical Care Reviews
about 1 year ago
The second trial result for
#CCR25
in Titanic Belfast in June is GASTROSAM Gastroenteritis Rehydration of African Children with Severe Acute Malnutrition Join us in June for the best critical care trials in the world Register at
criticalcarereviews.com/meetings/ccr25
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reposted by
David Harrison
Kerry Woolfall
about 1 year ago
Designing an adaptive platform trial with parents, young people and PICU staff in a NIHR accelerator grant. Here’s how we did it and what the platform should look like:
bmjopen.bmj.com/content/15/1...
@nihr.bsky.social
@trakmitch.bsky.social
@lyvonnetume.bsky.social
@liverpooluni.bsky.social
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Developing an adaptive paediatric intensive care unit platform trial with key stakeholders: a qualitative study
Objectives Platform trials were used successfully in adult populations during the COVID-19 pandemic. By testing multiple treatments within a single trial, platform trials can help identify the most ef...
https://bmjopen.bmj.com/content/15/1/e085142
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David Harrison
Nature
about 1 year ago
All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is. 🧪
www.nature.com/articles/d41...
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Why probability probably doesn’t exist (but it is useful to act like it does)
All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is.
https://www.nature.com/articles/d41586-024-04096-5
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David Harrison
Intensive Care Society
about 1 year ago
Want to advance as a leader in 2025? Apply for
#LeaP4
before 10 January to explore your leadership potential and explore modules on authentic leadership, managing work and emotional intelligence. Learn more below and join our transformative programme👇
bit.ly/leaP4
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Congratulations Rob!
@criticalcarereviews.com
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about 1 year ago
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David Harrison
JAMA
about 1 year ago
Published in JAMA with #CCRdownunder: In critically ill adults with suspected sepsis, antibiotic regimens were safely reduced when guided by measurement of procalcitonin but not by C-reactive protein. @criticalcarereviews.com
ja.ma/3BovM5v
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David Harrison
Marion Campbell
about 1 year ago
A design that came up in discussion at the
#ACTA
clinical trials conference last week was the”effectiveness-implementation hybrid design” 1/8
#MethodologyMonday
#108
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David Harrison
Critical Care Reviews
about 1 year ago
It's 9am in Melbourne Just 24 hours to CCR Down Under 8 major trial results Full, free livestream
https://criticalcarereviews.com
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David Harrison
Dr Victoria Shepherd
about 1 year ago
📢Now live📢 CONSULT e-learning on trials involving adults with impaired capacity to consent - 4 core modules, case studies, links to resources, free to access, download a certificate on completion 🔗https://www.capacityconsentresearch.com/training
@kerryhood.bsky.social
@ukctunetwork.bsky.social
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David Harrison
Critical Care Reviews
about 1 year ago
➡️ 8 major critical care trial results live from Melbourne ➡️ Full free livestream ➡️ Tuesday & Wednesday, December 10th & 11th ➡️ Times are UTC +11 ➡️https://criticalcarereviews.com
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Ciao, Luciano I’m honoured to have known you. A sad day for critical care. RIP
add a skeleton here at some point
about 1 year ago
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reposted by
David Harrison
Brian Bilston
about 1 year ago
Today’s poem is dedicated to all those who have taken it upon themselves to correct the grammar or spelling in my poems over the last few weeks. It’s called ‘Pedents’.
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Sharing good news on the
#UKROXtrial
from the other place…
about 1 year ago
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David Harrison
Critical Care Reviews
about 1 year ago
Registration for the Critical Care Reviews Meeting 2025 is now open ➡️ June 11th to 13th ➡️ Titanic Belfast, Belfast, Northern Ireland The Best Critical Care Trials in the World
criticalcarereviews.com/meetings/ccr25
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CCR25
Critical Care Reviews Meeting 2025, Titanic Belfast, June 11th to 13th. Featuring 12 major critical care trial results
https://criticalcarereviews.com/meetings/ccr25
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