Tatsuo Fukagawa (@tatsuofukagawa.bsky.social)

Our new paper was just out. CRISPR screening with a CENP-C mutant reveals that KIF18A and CENP-E are coordinately involved in chromosome congression. We also find that cancer cells with low levels of CENP-E are sensitive for KIF18A inhibition. Congrats Jiahang Miao! www.cell.com/cell-reports...

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KIF18A promotes chromosome congression in cooperation with CENP-E downstream of CENP-C Miao et al. demonstrate that KIF18A depletion causes synthetic defects with CENP-C hypomorphic mutant and KIF18A functions for chromosome congression in cooperation with CENP-E. CENP-E levels at kinet... https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01286-0