Tatsuo Fukagawa
@tatsuofukagawa.bsky.social
๐ค 67
๐ฅ 5
๐ 3
Cell Biologist, Centromere, Kinetochore
reposted by
Tatsuo Fukagawa
The EMBO Journal
about 1 month ago
Diversity in mechanisms for epigenetic specification of vertebrate centromeres: Tetsuya Hori,
@tatsuofukagawa.bsky.social
et al show that HJURP-dependent CENP-A deposition in chicken DT40 cells requires both Mis18 complex and CENP-C
link.springer.com/article/10.1...
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Our renent paper on CENP-A deposition was just out in EMBO J. Please check it out. Congrats Tetsuta!
link.springer.com/article/10.1...
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Dual pathways via CENP-C and Mis18C recruit HJURP for CENP-A deposition into vertebrate centromeres - The EMBO Journal
Centromere position is specified and maintained by sequence-independent epigenetic mechanisms in vertebrate cells, with the incorporation of the centromere-specific histone H3 variant CENP-A into chro...
https://link.springer.com/article/10.1038/s44318-025-00674-z#article-info
about 2 months ago
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reposted by
Tatsuo Fukagawa
Bungo Akiyoshi
2 months ago
Put together by Simona Giunta,
@tatsuofukagawa.bsky.social
,
@roneilllab.bsky.social
and myself. Big thanks to all the authors who contributed to this collection!
link.springer.com/article/10.1...
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40ย years of CENP-A: the foundation of a new era of centromere biology - Chromosome Research
Chromosome Research -
https://link.springer.com/article/10.1007/s10577-025-09790-2
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Our new paper was just out. CRISPR screening with a CENP-C mutant reveals that KIF18A and CENP-E are coordinately involved in chromosome congression. We also find that cancer cells with low levels of CENP-E are sensitive for KIF18A inhibition. Congrats Jiahang Miao!
www.cell.com/cell-reports...
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KIF18A promotes chromosome congression in cooperation with CENP-E downstream of CENP-C
Miao et al. demonstrate that KIF18A depletion causes synthetic defects with CENP-C hypomorphic mutant and KIF18A functions for chromosome congression in cooperation with CENP-E. CENP-E levels at kinet...
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01286-0
3 months ago
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I just started Bluesky.
about 1 year ago
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you reached the end!!
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