@tycheleturner.bsky.social
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📥 215
📝 43
A collaborator recently inspired me to revive plot-protein. The updated code is now on GitHub. Here is a link to the gallery of example protein plots:
github.com/tycheleturne...
#plotProtein
#bioinformatics
#genomics
#protein
#plot
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https://github.com/tycheleturner/plot-protein/blob/master/gallery/Gallery.md
29 days ago
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Video from the “ASHG 2025 Data Discovery Exchange, hosted by Kids First and INCLUDE”
youtube.com/watch?v=g67z...
#kidsfirstDRC
#TNTurnerLab
@washugenetics.bsky.social
#genomics
#genetics
#denovo
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ASHG 2025 Data Discovery Exchange, hosted by Kids First and INCLUDE
YouTube video by Gabriella Miller Kids First Data Resource Center
https://youtube.com/watch?v=g67zslSgEFc
about 1 month ago
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HAT-FLEX is a caller-agnostic, drop-in trio DNV detection tool that operates directly on existing VCFs. If you have feedback, please email or DM me. Thanks.
github.com/TNTurnerLab/...
#genetics
#genomics
#denovo
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GitHub - TNTurnerLab/HAT-FLEX: Flexible Trio DNV detection on existing VCFs.
Flexible Trio DNV detection on existing VCFs. Contribute to TNTurnerLab/HAT-FLEX development by creating an account on GitHub.
https://github.com/TNTurnerLab/HAT-FLEX
about 1 month ago
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New paper in @BiologyOpen: “Generation and characterization of a knockout mouse of an enhancer of EBF3.”
@washugenetics.bsky.social
@jacksonlab.bsky.social
journals.biologists.com/bio/article/...
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Generation and characterization of a knockout mouse of an enhancer of EBF3
Summary: This study focuses on the generation and initial characterization of a knockout mouse for a region of noncoding, regulatory DNA that was previously implicated in autism.
https://journals.biologists.com/bio/article/14/11/bio062070/369711/Generation-and-characterization-of-a-knockout
about 2 months ago
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Wow,
@github.com
contributions look different today. No green. It looks like corn 🌽 Happy Halloween!
about 2 months ago
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1/ WashU research news; excited to share our new paper on Chromosome 9p Syndromes 🧬 Hope you take the time to read it. Here is the link:
link.springer.com/article/10.1...
@washugenetics.bsky.social
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Whole-genome sequencing reveals individual and cohort level insights into chromosome 9p syndromes - Genome Medicine
Background Previous genomic efforts on chromosome 9p deletion and duplication syndromes have utilized low-resolution strategies (i.e., karyotypes, chromosome microarrays). These studies have provided ...
https://link.springer.com/article/10.1186/s13073-025-01563-0
about 2 months ago
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❤️
link.springer.com/10.1186/s130...
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Whole-genome sequencing reveals individual and cohort level insights into chromosome 9p syndromes - Genome Medicine
Background Previous genomic efforts on chromosome 9p deletion and duplication syndromes have utilized low-resolution strategies (i.e., karyotypes, chromosome microarrays). These studies have provided ...
https://link.springer.com/10.1186/s13073-025-01563-0
2 months ago
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Thank you to Dr. Evan Eichler for visiting
#WashU
and presenting in our Department of Genetics seminar series. An inspiring talk from one of my academic fathers!
@washugenetics.bsky.social
#genetics
#genomics
2 months ago
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Big milestone for the @TNTurnerLab as our very first postdoc officially started this week! Welcome Arvinden to the team! @WashUGenetics
#genomics
#genetics
#noncoding
#mpra
#postdoc
3 months ago
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🐭This week the detail sheet for the enhancer knockout mouse we describe in
doi.org/10.1101/2025...
became available at the MMRRC
www.mmrrc.org/catalog/sds....
. Please check it out if you are interested in ordering the mice.
#noncoding
#enhancer
#ebf3
#genomics
#genetics
@TNTurnerLab @WashUGenetics 🐭
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Generation and Characterization of a Knockout Mouse of an Enhancer of EBF3
Genomic studies of autism and other neurodevelopmental disorders have identified several relevant protein-coding and noncoding variants. One gene with an excess of protein-coding de novo variants is E...
https://doi.org/10.1101/2025.01.09.631762
3 months ago
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Just an FYI: I am not, nor have I ever been, affiliated with Boston University. The ASHG program listed me there in error. I remain with Washington University in St. Louis
@washugenetics.bsky.social
. ASHG has been notified, and I appreciate those who reached out about the inaccurate listing.
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4 months ago
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Here’s to all my colleagues rocking bowties! Happy
#BowtieDay
! Shoutout to Sandy Boynton for the image.
#Style
#WorkLife
4 months ago
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reposted by
Megan Dennis
5 months ago
Check out our latest work co-led by
@dcsoto.bsky.social
and
@jmuribescr.bsky.social
identifying hundreds of human duplicated gene families using the new T2T-CHM13 assembly, with a focus on those potentially contributing to brain evolution 🧪:
authors.elsevier.com/a/1lTQtL7PXu...
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https://authors.elsevier.com/a/1lTQtL7PXuFSV
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New from TNTurnerLab at WashUGenetics! Check out our latest paper on efficient genome-wide copy number genotyping in WGS data:
sciencedirect.com/science/arti...
Also explore the CNPI toolkit powering this work:
github.com/TNTurnerLab/...
#genomics
#WGS
#copyNumber
#cnv
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CNPI: Rapid Analyses of Human Copy Number Data
Tools for genotyping copy number in whole-genome sequencing (WGS) data exist. Despite their availability, there are a limited number of tools that eff…
https://sciencedirect.com/science/article/pii/S0022283625003791?via%3Dihub
5 months ago
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Currently, I have a a formal postdoctoral job listing for a position in @TNTurnerLab @WashUGenetics, See also
turnerlab.wustl.edu/employment/
and
wustl.wd1.myworkdayjobs.com/External/job...
.
#genomics
#genetics
#neuroscience
#molecularBiology
#computationalBiology
#oncology
#postdoc
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Employment
Students Graduate students in the Division of Biology & Biomedical Sciences at Washington University School of Medicine are welcome to contact Dr. Turner to discuss potential rotation projects.…
https://turnerlab.wustl.edu/employment/
7 months ago
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View my verified achievement from Compass Training and Mentoring Program at Washington University School of Medicine in St. Louis.
www.credly.com/badges/7ac68...
via @credly
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Compass Foundational Training was issued by Compass Training and Mentoring Program at Washington University School of Medicine in St. Louis to Tychele Turner.
The Compass program provides researchers with the training and mentoring they need to successfully launch their careers. Program Scholars receive guidance and tools to be intentional about leading the...
https://www.credly.com/badges/7ac68e3c-de73-4ba1-b23c-4ac09dfcd433/twitter
8 months ago
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Visium HD Spatial Transcriptomics of E13.5 Wild Type Mouse Head we generated in our preprint
medrxiv.org/content/10.1...
is now available on Zenodo
doi.org/10.5281/zeno...
.
#genomics
#genetics
#9p
#neuroscience
#brain
#development
9 months ago
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reposted by
GitHub
9 months ago
⭐ In 2005, Git made its first commit. ⏩ Fast-forward to 2025, we relive the birth of Git with the creator, Linus Torvalds. ❤️ Head down memory lane with us.
github.blog/open-source/...
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Happened upon this interesting website
42basepairs.com/browse
. Came across it today when looking at some publicly available whole-genome sequencing data.
#genetics
#genomics
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Browse - 42basepairs
https://42basepairs.com/browse
9 months ago
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Our new collaborative preprint is online now “Whole-Genome Sequencing Reveals Individual and Cohort Level Insights into Chromosome 9p Syndromes”
www.medrxiv.org/content/10.1...
and is the result of many colleagues working together towards understanding of 9p-related syndromes
#genomics
#genetics
#9p
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Whole-Genome Sequencing Reveals Individual and Cohort Level Insights into Chromosome 9p Syndromes
Previous genomic efforts on chromosome 9p deletion and duplication syndromes have utilized low resolution strategies (i.e., karyotypes, chromosome microarrays). We present the first large-scale whole-...
https://www.medrxiv.org/content/10.1101/2025.03.28.25324850v1
9 months ago
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reposted by
10 months ago
Excited to share new joint publication with the Tychele Turner lab at WashU now published in Cell Genomics! We do a proteome-wide assessment of differential missense variant clustering in neurodevelopmental disorders and cancers and find some interesting differences!
tinyurl.com/2p9j559n
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Proteome-wide assessment of differential missense variant clustering in neurodevelopmental disorders and cancer - PubMed
Prior studies examining genomic variants suggest that some proteins contribute to both neurodevelopmental disorders (NDDs) and cancer. While there are several potential etiologies, here, we hypothesiz...
https://pubmed.ncbi.nlm.nih.gov/40073865/
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Just curious, has anyone ever generated a complete T2T human genome assembly using only PacBio HiFi data?
www.pacb.com/vega-genomes...
If yes, that would be awesome. Please post the link.
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Vega genomes datasets - PacBio
Explore Vega genomes demo datasets on Vega benchtop system
https://www.pacb.com/vega-genomes-datasets/
10 months ago
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Our new paper is online today in Cell Genomics “Proteome-wide assessment of differential missense variant clustering in neurodevelopmental disorders and cancer”
www.cell.com/cell-genomic...
#genetics
#protein
#cancer
#neurodevelopmentalDisorder
#TNTurnerLab
@washugenetics.bsky.social
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Proteome-wide assessment of differential missense variant clustering in neurodevelopmental disorders and cancer
Proteins implicated in neurodevelopmental disorders (NDDs) and cancer have been identified from analyses of genomic variation. Some of these proteins occur in both phenotypes, but the reason for this ...
https://www.cell.com/cell-genomics/fulltext/S2666-979X%2825%2900063-1
10 months ago
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Today, TNTurnerLab undergraduate researcher Emily Cordova Hurtado presented her project “Generation and Characterization of a Knockout Mouse of an Enhancer of EBF3”
@washugenetics.bsky.social
department seminar today!
#genetics
#genomics
10 months ago
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11 months ago
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Check out our new collaborative preprint “Generation and Characterization of a Knockout Mouse of an Enhancer of EBF3” on bioRxiv
#genetics
#ebf3
#mouse
#enhancer
#noncoding
#genomics
www.biorxiv.org/content/10.1...
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Generation and Characterization of a Knockout Mouse of an Enhancer of EBF3
Genomic studies of autism and other neurodevelopmental disorders have identified several relevant protein-coding and noncoding variants. One gene with an excess of protein-coding de novo variants is E...
https://www.biorxiv.org/content/10.1101/2025.01.09.631762v1
12 months ago
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reposted by
about 1 year ago
www.youtube.com/watch?v=c8Bz...
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IDDRC Introduction by Co-directors Joseph Dougherty, PhD and Christina A. Gurnett, MD, PhD
YouTube video by WashU IDDRC
https://www.youtube.com/watch?v=c8Bz56-_W8w&feature=youtu.be
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I am looking for serious applicants who are interested in doing a postdoc in Human
#Genetics
in my lab. Looking for wet and/or dry lab postdocs. If you are interested, DM me.
about 1 year ago
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Job posted for a research technician in my lab. If you are interested, please DM me.
#genomics
#genetics
We just got some new lab toys!
about 1 year ago
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7 years & keep enhancing El genoma pequeño (EGP). Updates have expanded capabilities to include mitochondrial genome copy number estimates, building upon original tools for haplogroup & heteroplasmy analyses.
github.com/tycheleturne...
#mitochondria
#genomics
#genetics
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GitHub - tycheleturner/ElGenomaPequeno: El genoma pequeño - analysis workflow for "the little genome"
El genoma pequeño - analysis workflow for "the little genome" - tycheleturner/ElGenomaPequeno
https://github.com/tycheleturner/ElGenomaPequeno
almost 2 years ago
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New preprint
www.medrxiv.org/content/10.1...
out from @TNTurnerLab and Dr. Rachel Karchin's lab. This one is very special to me because almost every trainee who has passed through my lab has worked on this project over the last 4.5 years. 1/5
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Proteome-Wide Assessment of Clustering of Missense Variants in Neurodevelopmental Disorders Versus C...
medRxiv - The Preprint Server for Health Sciences
https://www.medrxiv.org/content/10.1101/2024.02.02.24302238v1
almost 2 years ago
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A perspective piece I wrote for
@thetransmitter.bsky.social
is online now. It is a 6 minute read and provides insights into the application of long-read sequencing in several areas of
#neuroscience
. Hope you enjoy!
#genomics
#longReads
add a skeleton here at some point
about 2 years ago
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