New preprint! Structural variant evolution + cancer WGS. SV cancer cellular fraction + SV phylogenies. In longitudinal mCRPC on bipolar androgen therapy. hyper-rearranged subclones are pruned, resistant lineages expand. tinyurl.com/yvpystvt @laurasenamd.bsky.social #ProstateCancer #PrecisionOncology

🚨 New preprint!
We introduce PICTographPlus — a method to recover clone‑specific transcriptomes from bulk DNA + RNA sequencing (no single‑cell required!). 🧬💻 See bioRxiv 👉 www.biorxiv.org/cgi/content/... @fertiglab.bsky.social @break-cancer.bsky.social #CancerGenomics #TumorEvolution #Bioinformatics

Excited to share new joint publication with the Tychele Turner lab at WashU now published in Cell Genomics! We do a proteome-wide assessment of differential missense variant clustering in neurodevelopmental disorders and cancers and find some interesting differences! tinyurl.com/2p9j559n

Karchin Lab at Johns Hopkins is excited to announce a postdoctoral position focused on developing innovative methods in computational immuno-oncology. Great opportunity if you are passionate about advancing cancer immunotherapy and bioinformatics. Learn more/apply: karchinlab.org/join-us/

The Karchin Lab at Johns Hopkins is excited to announce a postdoctoral position focused on developing innovative methods in computational immuno-oncology. A great opportunity for researchers passionate about advancing cancer immunotherapy and bioinformatics. Learn more/apply: tinyurl.com/25ehczwb

The Karchin Lab at Johns Hopkins is excited to announce a postdoctoral position focused on developing innovative methods in computational immuno-oncology. A great opportunity for researchers passionate about advancing cancer immunotherapy and bioinformatics. Learn more/apply here: lnkd.in/ehEwbKPn

Check out the new preprint from karchinlab.org tinyurl.com/vxm7b6n6 about a new computational method to estimate the cellular prevalence of somatic structural variants in tumors from bulk DNAseq. #genomics #cancer #bioinformatics #tumor_evolution @hopkinsengineer.bsky.social