There needs to be more clarity about what the #NHS10YearPlan offers for patients and what “good enough” looks like in terms of access, along with careful co-design and evaluation of the detail of each of the three shifts. Full paper: ths.im/4b6oPWp THIS Summary: ths.im/49oDU4k

Maybe we should stick to a message this simple.

We’re delighted to announce that Professor Trish Greenhalgh @trishgreenhalgh.bsky.social will deliver this year’s CPM Annual Lecture, 'Personalised Medicine: A Primary Care Perspective' 🗓 28 April 2026 | 📍 Maths Institute, Oxford Find out more and register here: cpm.ox.ac.uk/event/cpm-an...

@emmylooroll.bsky.social said "Gene editing is absolutely a possibility, as is modifying downstream pathways. Genes aren’t all doom & gloom!🧬"

Yes for most of the population it will be modest, looking at the extremes of risk for a population doesnt tell you what the shift in probability would be with intervention for most.

Gene therapy in ~95% of the population is the naive concept here: manipulating the genomes of most people for only a modest shift in prob. This why, in public discussion, it is more appropriate to talk about genes as modifying risk alongside other factors, not singular “causes” to be edited away.

yep and as I said, fine in that setting- it was the press release I was responding to-'most alzheimer's cases linked to single gene' we lose the nuance that for 95% population carrying E3/E4, modifiable lifestyle factors remain the dominant lever for prevention.

Calling the most common human variant a 'risk allele' is methodologically correct but nosologically problematic—it redefines disease categorisation in a way that obscures rather than clarifies the distinction between genetic susceptibility and modifiable risk pathways.

🧬 How well do ethnicity labels actually work in genomic medicine? Our new blog explores the challenges - and the pathways to more inclusive, meaningful data. ➡️ cpm.ox.ac.uk/thinking-out... #Genomics #HealthEquity #DiversityInResearch

You can find out more about the competition and enjoy the amazing winning entries from previous years here: cpm.ox.ac.uk/art-and-scie...

Our 2024–25 Annual Report is now live! Reflecting on a year of collaboration, engagement, and impact at the CPM. Explore our flagship events, annual lectures, and creative outreach. ➡️ Read more here: cpm.ox.ac.uk/wp-content/u...

I think we're talking difference between "cause" in epidemiology and what pple understand in everyday speech. IMO "cause" misleads into thinking gene more deterministic than it is. for single dominant risk like smoking, "cause" is fine, but for multifactorial conditions "modifies risk" is better

I'm really looking forward to this. @CPM we have been fortunate to have absolutely stellar annual lecturers- see here for recordings of the last few years: cpm.ox.ac.uk/series/cpm-a... and @trishgreenhalgh.bsky.social will be no exception

I'll be giving the Annual Guest Lecture for the Oxford Centre for Personalised Medicine. On 28th April 2026 at 5.30 pm. ‘Personalised Medicine, a Primary Care Perspective’. Open to all. cpm.ox.ac.uk/event/cpm-an...

And 👏 to Honourable exception 🤭

Thanks for waking me out of bluesky inactivity! Presume this on the back of my SMC quote? My point was that if >95% population have a genotype, it is pretty meaningless to talk about it being causative of disease. Quite happy with apoE alleles *modifying risk* of Alzheimer’s

Brilliant! I did not know this paper so thanks from infrequent bluesky user for this nugget reposted.

Have you got a patent application in? Have you been to Sandhill Road in Palo Alto for funding? Why not??? BTW add the strong prediction that the kid will drink milk!

We get the politics the few pay for. #democracy - it would be a good idea www.theguardian.com/politics/202...

Worried that using ChatGPT harms the planet? A new analysis shows each query uses less energy than a Google search – and far less than lighting a bulb or streaming TV. @eastangliabylines.co.uk

“This thing is definitely bad for us but no one can say what it is”

Sounds very appealing: www.theguardian.com/lifeandstyle...

#BBCNews - Holocaust survivor and educator Manfred Goldberg dies aged 95 www.bbc.com/news/article...

A List of Things Said to Have Been Ruined by Women 🧵

Over the last months, we’ve entirely rebuilt search on Our World in Data — we just launched it: ourworldindata.org/introducing-... Let me know what you think. Does it work for you?

BBC vandalism, in an Age of Science to destroy the one science news programme left, after trivializing Science Now. These two programmes were once consecutive & complemented each other, treating listeners as adults.

Sharing this 🎯 post from @barryhunt008.bsky.social over here: "Wow 🤩 Public Health messaging 100 years ago 👏👏👏"

Sometimes I see a pre-print and pray to the science communication gods that it isn’t reported in the news as though it is a peer reviewed study.

Your periodic reminder that mRNA vaccines are a scientific and public health game-changer. Those that have been approved have passed stringent efficacy and safety checks. They protect you and your child against potentially fatal diseases. You may, however, get a sore arm.

Talent is everywhere, opportunity isn’t. In this letter to the editor, a former teacher reflects on her pupils’ hopes, and the barriers some will face ⤵️ @eastangliabylines.co.uk

"LLMs are common-sense repositories. Yes, they can remix and recycle our knowledge in interesting ways. But they are trapped in the vocabularies we’ve encoded in our data and trained them upon. Large-language models are dead-metaphor machines." buildcognitiveresonance.substack.com/p/there-is-n...

Join our rescheduled online Bradford Hill Seminar with @alucassen.bsky.social, discussing: Diagnostic and predictive journeys: Finding the right balance in genomic medicine 📅 Wed 26 November, 1 PM (UK) Register buff.ly/U06QZ9N @dphpc.bsky.social @mrc-bsu.bsky.social @phgfoundation.bsky.social

Plastic is often seen as a cheap material but scientists in The Lancet argue it is expensive when including damage to health One estimate of the health damage from just three plastic chemicals – PBDE, BPA and DEHP – in 38 countries was $1.5tn a year. www.theguardian.com/environment/...

Sheep are destroying precious British habitats – and we taxpayers are footing the bill to the tune of millions in a climate and biodiversity emergency - it’s bad and bonkers ! ⁦Me for The Guardian . . . @wildjustice.bsky.social www.theguardian.com/commentisfre...

Agreed, Brit soc genetic Medicine wrote a briefing on this: bsgm.org.uk/media/12702/...

This this this Washing hands and wiping down surfaces will not do much to protect children from a deadly, highly infectious, airborne virus. Vaccinate and ventilate.

In a world of polarized headlines, Katharine Hayhoe is cutting through the noise. She’s not just a top climate scientist — she’s showing how to talk about climate in ways that build trust, not division. 📰 Read more on Scientista:

Love this. Meanwhile can someone please hunt down whoever "Kiroe" is, and make it manifestly clear to them that their graffiti tag sucks and they're never to deface Belfast/Newtownabbey/Carrick ever again...

Greatly enjoying this book by a physicist turned sociologist explaining why you need more than the laws of physics to explain societal problems.

People often intuitively interpret genetic ancestry PCA plots as simple genetic distances, but this is not always the case. Below are random pairs of individuals that are far apart in PCA space (lines) but actually have fewer total variant differences (numbers).

Email Yvette Cooper and tell her that the right to protest is part of any functioning democracy and if she wants to even pretend we’re that, she needs to stop preventing pretty much all protest the government doesn’t like. action.greenpeace.org.uk/e/854853/4lP...

Shaimaa has a scholarship to do a PhD on Palestinian literature with me at @uoe-llc.bsky.social, but she's stuck in Gaza because the foreign office won't help. Please share. www.telegraph.co.uk/world-news/2...

Good but remember more terminally ill die at home. So hospice at home services also need support. www.gov.uk/government/n...

'Moonshine' by contemporary UK printmaker Janis Goodman #WomensArt

AI is going to revolutionize everything

Review of PROOF @thelancet.com by @philipcball.bsky.social www.thelancet.com/journals/lan...

ChatGPT and Grok absorb fake news and regurgitate it when asked. Due to their design, these models and their competitors are highly susceptible to disinformation, reports Pablo G. Bejerano for El País. english.elpais.com/technology/2...

Thank you for sharing, especially important now that the health secretary will want you to practice preventative medicine from the cloudy crystal ball of whole genomes at birth!

In the new issue of @cp-trendsgenetics.bsky.social, @wiringthebrain.bsky.social & Nick Cheney seek out a better metaphor. They propose a generative model concept to capture the indirect, distributed, & non-linear relationship between info in the genome & form of the organism. Worth a read: 🧬👇🧪 11/11