Giovanni Di Liberto, MD-PhD
@dilibertomd.bsky.social
📤 64
đź“Ą 43
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Neurologist / Scientist investigating the pathobiological mechanisms in Autoimmune Neurology
reposted by
Giovanni Di Liberto, MD-PhD
Trends in Neurosciences
22 days ago
'Neuronal STAT1 as a phase switch from antiviral defense to synaptopathy in encephalitis' by Giovanni Di Liberto & Doron Merkler
@dilibertomd.bsky.social
www.cell.com/trends/neuro...
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When does antiviral defense become neuronal injury? We’re excited to share our latest work uncovering neuronal STAT1 as a molecular phase switch from protective antiviral defense to synaptopathy in encephalitis.
@fbm-unil.bsky.social
@cp-trendsneuro.bsky.social
www.cell.com/trends/neuro...
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Neuronal STAT1 as a phase switch from antiviral defense to synaptopathy in encephalitis
Interferon signaling is essential for antiviral defense in the central nervous system, yet sustained neuronal STAT1 phosphorylation (pSTAT1) can promote immune-mediated synaptic and network injury. In...
https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(26)00078-0
29 days ago
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Chicken or egg in neurodegeneration ? In IgLON5 disease, the answer is becoming clear: autoantibodies initiate the cascade, tau comes later. In our Brain Editorial, with
@mayo-aing.bsky.social
, we explore how this reshapes timing, diagnosis, and treatment.
academic.oup.com/brain/articl...
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A chicken-or-egg dilemma resolved: autoantibodies initiate neurodegeneration
IgLON5-antibody disease occupies a unique position at the interface between autoimmunity and neurodegeneration.1 By typically presenting with multiple, slo
https://academic.oup.com/brain/article/149/5/1423/8667467
about 1 month ago
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reposted by
Giovanni Di Liberto, MD-PhD
John Lukens
11 months ago
Neural anticipation of virtual infection triggers an immune response
www.nature.com/articles/s41...
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Neural anticipation of virtual infection triggers an immune response - Nature Neuroscience
Serino et al. show that seeing an infectious avatar approach the body in virtual reality triggers an immune response, indicating that the brain prepares the body to fight infections even for perceived...
https://www.nature.com/articles/s41593-025-02008-y
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reposted by
Giovanni Di Liberto, MD-PhD
John Lukens
10 months ago
Lipid metabolism and neuroinflammation: What is the link?
rupress.org/jem/article/...
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Our new paper is finally out! A terrific joint effort to advance our understanding of T cell mediated neurodegeneration in AE ! “Neuronal pSTAT1 hallmarks synaptic pathology in autoimmune encephalitis against intracellular antigens”
link.springer.com/article/10.1...
about 1 year ago
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reposted by
Giovanni Di Liberto, MD-PhD
John Lukens
over 1 year ago
Divergent sex-specific pannexin-1 mechanisms in microglia and TÂ cells underlie neuropathic pain: Neuron
www.cell.com/neuron/fullt...
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Divergent sex-specific pannexin-1 mechanisms in microglia and TÂ cells underlie neuropathic pain
Panx1 channels mediate sex-specific immune mechanisms in neuropathic pain: leptin from CD8+ TÂ cells drives pain in females, while VEGF from microglia mediates pain in males. Panx1-targeted therapies o...
https://www.cell.com/neuron/fulltext/S0896-6273%2825%2900009-1
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reposted by
Giovanni Di Liberto, MD-PhD
Joe Sabatino
over 1 year ago
T cell trogocytosis gets crazier and crazier
www.science.org/doi/10.1126/...
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Trogocytosis of chimeric antigen receptors between T cells is regulated by their transmembrane domains
Chimeric antigen receptor trogocytosis transfers antitumor immunity between T cells and is dictated by their transmembrane domain.
https://www.science.org/doi/10.1126/sciimmunol.ado2054
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reposted by
Giovanni Di Liberto, MD-PhD
over 1 year ago
Pour l'année 2024, la Commission de la
#Recherche
de la
@fbm-unil.bsky.social
(CRFBM) a mis au concours différents types de
#financement
en
#médecine
de
#précision
. đź’¸ DĂ©couvrez les
#récipiendaires
des 5 projets retenus! ➡
www.unil.ch/news/1733846...
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Maudes et al. present a new mouse model of anti-NMDAR encephalitis, which provides a platform for studying the underlying disease mechanisms and allows testing of treatments over an extended disease course.
tinyurl.com/muc9f8fx
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Neuro-immunobiology and treatment assessment in a mouse model of anti-NMDAR encephalitis
Maudes et al. have developed a mouse model of anti-NMDAR encephalitis, an autoimmune disease mediated by autoantibodies against the GluN1 subunit of the NM
https://tinyurl.com/muc9f8fx
over 1 year ago
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