📊 Polygenic risk and rare variants in endotypes of idiopathic pulmonary fibrosis: a genetic analysis of population-based and case–control cohorts 🔹 Common and rare genetic variation confer context-specific genetic risk in #IPF, both competitively and cooperatively 🔓 tinyurl.com/ycxxpxf5

Genetic heterogeneity in IPF has been a major gap. In our new paper, we define genetic endotypes of IPF, uncover subtype-specific risk, improve disease prediction, and identify telomere-associated polygenic risk as a key, previously unrecognized driver. thelancet.com/journals/lan...

Age-dependent Genetic Risk in Pulmonary Fibrosis Patients and Relatives https://www.medrxiv.org/content/10.64898/2026.01.07.25342496v1

I’m delighted to partner with Uplifting Athletes and @teamtelomere.bsky.social! This grant will enable new research to support the 1 in 10 Americans diagnosed with a #RareDisease. Join me as #WeTackleRare at the Young Investigator Draft on Jan. 31! #YID26 bit.ly/yid2026 @columbiamed.bsky.social

Genetic Associations in Non-Europeans with Pulmonary Fibrosis: Analysis of the All of Us Cohort Key genetic risk factors of IPF are less prevalent in non-European individuals but confer similar risk of disease when present @davidzhangmd.bsky.social #medsky 🔗 tinyurl.com/2w8jpj9r

This is a big advance, folks. We've never had a disease-modifying drug for this devastating inherited disease www.science.org/content/arti... www.washingtonpost.com/health/2025/... www.economist.com/science-and-...

Delighted to share our new study evaluating the association of rare variants in telomere and non-telomere monogenic adult-onset Pulmonary Fibrosis genes and IPF patient survival where we also intersected their effects with #PRS of IPF.