NEW PREPRINT! We systematically reviewed molecular epidemiology studies looking at strain discordance in pairs of people with TB disease and history of household contact We found 30 studies from 18 countries. Excluding 4 studies at high risk of bias, we had data on 1544 household case pairs [1/n]

Trial of High-Dose Oral Rifampin in Adults with Tuberculous Meningitis Congratulations to David Meya, Fiona Cresswell, @natebahrid.bsky.social @drboulware.bsky.social & co on this important trial No mortality benefit to high dose rifampin in adults with TB meningitis www.nejm.org/doi/full/10....

The biologist's view of how flight works. Courtesy of Rory Maizels. #GenerativeBiology

⚡️New preprint (not peer-reviewed)⚡️ In the SaDAPT trial with people with #HIV and #tuberculosis symptoms in 🇲🇼🇱🇸, we investigated if antiretroviral therapy should be initiated immediately, or delayed until TB results available. ssrn.com/abstract=523... Outcomes (incl. IRIS) similar across both arms.

This is why clinical trials are important. Unfortunately tecovirimat did not improve resolution of clade IIb mpox compared to placebo. There are currently no effective antivirals for the treatment of mpox and this is an urgent need. Disappointing result but at least we know.

After 10 years of practice; First case of Melioidosis at my 🏥 #IDsky

To reiterate - if we could find our new journal content on here - also BMJ, Lancet, NEJM, JAMA - it would be just perfect and all could deactivate accounts at the old place…which no longer seems somewhere for medicine and research

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DYK in 1957, Glasgow, Scotland ran the largest ever screening campaign against #tuberculosis? 715,000 people (76% of entire adult population) were X-rayed over just 5 weeks! In a new study, we looked at the long-term impact of this campaign. journals.plos.org/plosmedicine... #episky #idsky 🧪🛟

Our hybdid meeting on indirects effects of CMV infection is ONLY 1 WEEK AWAY Not too late to snap up FREE TICKETS Sessions on paediatrics, immunocompromised host, CMV-TB and critical illness/immunosenescence Keynote from STANLEY PLOTKIN! royalsociety.org/science-even... #IDsky #virology #episky