We are committed to supporting #CancerCare providers and patients who may be affected by public health issues. A listing of measles and vaccination resources can be found on our website and will continue to be updated: asco.org/news-initiat...

AAI, @acpimphysicians.bsky.social, and a coalition of 34 leading scientific and medical organizations have issued a joint statement to affirm vaccine safety amid rising misinformation and declining trust. Read the full statement: ow.ly/xtoP50VjT02.

Skull and Ivy #art #drawing #anatomy #science #sciart #medsky

MHC Expression and the Effectivenes of mRNA Vaccines in Cancer Therapy Part 2 #science #sciart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky #immunosky

MHC Expression and the Effectivenes of mRNA Vaccines in Cancer Therapy Part 1 #science #sciart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky #immunosky

Tumor Mutational Burden and the Effectivenes of mRNA Vaccines in Cancer Therapy #science #sciart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky #immunosky

Tumor Mutation Rate and the Effectivenes of mRNA Vaccines in Cancer Therapy #science #sciart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky #immunosky

Tumor Microenvironment (TME) and the Effectivenes of mRNA Vaccines in Cancer Therapy Part 2 #science #sciart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky #immunosky

Tumor Microenvironment (TME) and the Effectivenes of mRNA Vaccines in Cancer Therapy Part 1 #science #sciart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky #immunosky

NEW IMMUNE SYSTEM ANALOGY which fell out of my brain during class (hooray): You have two wheely bins for trash. One bin is for trash that you generate in your house (MHC I). If drug paraphernalia is found in that bin, your house is going to get raided and destroyed (cytotoxic T cell). (1/2)

Synthetic Spore Husk-Encased Lipid bilayer (SSHELs) mimic bacterial spores and deliver peptides to dendritic cells, showing efficient tumor regression and improved survival in mice. SSHELs require complex synthesis but avoid cell culture use, unlike VLPs. #MedSky #MedEd #medschoolsky #immunosky

Further Therapies to Enhance #IFNγ Production and #MHC I Expression in #cancer besides IL-2 mRNA #science #sciart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky #immunosky full lecture buff.ly/3XnyKPn

mRNA vaccines, COVID-19 or otherwise, are not gene therapy. Misconceptions & misinformation have eroded progress in science innovation. 2 main reasons: 1) misunderstanding of nuanced science 2) intentional spread of falsehoods 1/

Overcoming #MHC Downregulation in #Cancer Therapy by Modifying #mRNA #Vaccination #science #sciart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky #immunosky full lecture buff.ly/3XnyKPn

#Immunescape mechanisms to alternative immune activation pathways in #MHC deficient #cancer #science #sciart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky #immunosky full lecture buff.ly/3XnyKPn

Alternative immune activation pathways in #MHC deficient #cancer #science #sciart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky #immunosky full lecture buff.ly/3XnyKPn

Measles outbreaks are not normal. Measles was eliminated in 2000 due to successful vaccination campaigns. Declining vaccination rates since have led to an increase in measles outbreaks. The good news is #measles is preventable with the MMR vaccine. Learn more: ow.ly/wmo350V7LEQ. #Immunology

Consequences of #MHC downregulation in #cancer therapy #science #sciart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky #immunosky full lecture buff.ly/3XnyKPn

Causes of #MHC downregulation in #cancer #science #sciart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky #immunosky full lecture buff.ly/3XnyKPn

Review @annualreviews.bsky.social @lucasite-lab.bsky.social Decoding Immunobiology Through Genetic Errors of Immunity www.annualreviews.org/content/jour...

A fresh and fun way to learn about our immune system! fantastically made as well!

#mRNA #vaccine production: mRNA is synthesized from plasmid DNA encoding a pathogen’s antigen. Bacteriophage polymerases transcribe it in vitro. Purified by HPLC, it is encapsulated in lipid nanoparticles, filtered, and stored in vials. #meded #medsky #publichealth DOI: 10.1186/s12943-021-01339-1

Measuring MHC-Peptide affinity via Peptide Seq: Peptides are incubated with dendritic cells to form peptide-MHC complexes. MHC-peptide complexes are extracted, separated by liquid chromatography, sequenced via mass spectrometry, and validated with transcriptome data. #vaccines #medsky #immunosky

HPV vaccines are proven safe, with no severe side effects. They do not lead to increased sexual activity, debunking a common myth. Vaccination significantly reduces the risk of HPV-related cancers in both men and women, underscoring its importance. #health #vaccination #hpv #cancer

#Measles infections weaken immunity long-term, increasing infection-related mortality. The virus replicates in immune cells, causing their death and reducing the antibody repertoire, underscoring the need for MMR #vaccination. #health #medsky #meded

Also because of the times in which we live- if you have ever had a question about the HPV vaccine, I probably covered it here (and if I haven't please ask me in the replies and I will do my best to answer or find someone who can answer) #medsky #pedsky #immunosky #episky #IDsky 🧪

Measuring MHC-Peptide affinity-competition binding assay: MHC is extracted from DC and precipitated with HLA antibodies, incubated with radioactively labeled standard and test peptides, and the radiation intensity is used to calculate IC50 values, reflecting peptide-MHC affinity. #vaccines #medsky

Vaccine production requires detecting immunogenic antigens. Immunogenicity depends on antigen-MHC affinity and presentation to immune cells. The stabilization method quantifies peptide-MHC affinity, aiding in optimizing vaccine development by selecting effective targets. #oncology #vaccines #biotech

Quantification of MHC-peptide affinity using the stabilization method: -Cells receive radiolabeled peptides -Peptides bind MHC if affinity is high -Complexes are isolated with antibodies -Complexes are purified via SDS-PAGE -Scintillation quantifies radioactivity to derive IC50 #immunosky #meded

#3D #Model of a human #brain from #MRI scan #science #art #MedicalEducation

DNA damage activates ATM-dependent apoptosis in B cells. ATM and Bcl-2 defects promote lymphomas, inhibit apoptosis, and worsen prognosis. APO-1 mutations block TNFα-induced cell destruction. #science #sciart #medsky #edusky #MedSky #MedEd #medschoolsky #cancer

#histology: liver in HE staining #science #sciart #medsky #MedEd #MedicalEducation #medschoolsky

The Ras protein (KRAS, NRAS, HRAS) activates MAPK and PI3K pathways. Mutations promote B-cell malignancies. MLL-1 defects increase transcription and proliferation, common in B-ALL, with poor prognosis. #science #sciart #medicaleducation #medicalschool #cancer

CD8+ T cells develop into cytotoxic T cells (CTLs) with support from antigen-presenting and CD4+ T cells. CTLs kill target cells via cytotoxins and apoptosis. Natural killer cells enhance the response by targeting low-MHC-I cells, while dendritic cells activate T cells. #science #MedEd #immunosky

Neoantigen presentation via MHC-II activates CD4+ T cells, inducing TH1/TH17 differentiation and cytokine release. CD4+ cells aid cytotoxic responses via Fas-FasL, IFN-γ, and TNF-α. Memory TH1 cells ensure adaptive immunity, reducing collateral damage. #science #sciart #medsky #MedEd #immunosky

The liver produces proteins, stores vitamins, makes bile, regulates carbs, and detoxifies. Fatty liver disease, often from alcohol, can cause organ failure, cirrhosis, liver cancer, and esophageal varices. #science #sciart #medsky #edusky #MedEd #MedicalEducation #medschoolsky

The production of personalized #mRNA #vaccines in #cancer therapy #science #sciart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky #immunosky #immunology #rnabiology

#immunosky #immunology #rnabiology

#histology: pancreas in HEstaining #science #sciart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky

The detection of immunogenic neoantigens for personalized #mRNA #vaccines in #cancer therapy #science #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky #biotech

Comparison: Mass Spectrometry Imaging (MALDI MSI) vs Gene expression analysis #science #sciart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky

Burkitt lymphoma: In the blood smear, vacuolated blasts with very basophilic plasma, as well as round, sometimes multiple cell nuclei alongside bright macrophages can be seen. #science #skiart #medsky #edusky #MedEd #MedicalEducation #medschoolsky

Comparison: Mass Spectrometry Imaging (MALDI MSI) vs Immunohistochemistry #science #skiart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky

@physiciandemocracy.medsky.social If you can’t get your dangerous disinformation published by peer reviewed, reputable journals you just make you own official-sounding crap association to do to for you.

Uses of Mass Spectrometry Imaging (MALDI MSI) Part 3 #science #skiart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky

Uses of Mass Spectrometry Imaging (MALDI MSI) Part 2 #science #skiart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky

Uses of Mass Spectrometry Imaging (MALDI MSI) Part 1 #science #skiart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky

Multiple enlarged plasma cells in bood smear indicating a multiple myeloma. #science #skiart #medsky #MedEd #MedicalEducation #medschoolsky

Method of Mass Spectrometry Imaging (MALDI MSI) Part 2 #science #skiart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky

Method of Mass Spectrometry Imaging (MALDI MSI) Part 1 #science #skiart #medsky #edusky #academicsky #MedSky #MedEd #MedicalEducation #medschoolsky