conformational change in the actin-binding domain of α-catenin is required for adherens junction maturation as researchers from @uni-muenster.de show www.nature.com/articles/s42...

The Project on Poverty in Neuroblastoma Evolution team from @umich.edu published a study on how socioeconomic stressors (here, food insecurity) can have an influence on cancer dynamics www.nature.com/articles/s42...

A new study reveals distinct neural substrates of apathy, effort and reward valuation in humans www.nature.com/articles/s42...

New research on extracellular vesicles in ovarian cancer from Nagoya, Japan - www.nature.com/articles/s42...

Single-cell spatial transcriptomics reveals that CAFs at the invasive front of colorectal tumors induce pro-invasive changes in budding cancer cells - research from - among others - @au.dk www.nature.com/articles/s42...

a bit delayed, but still hot: ‪‪A phylodynamic study, conducted in southwestern France, on the importance of farm density when it comes to avian influenza spread: www.nature.com/articles/s42... @claireguinat.bsky.social @epidesa.bsky.social

In France: single introduction>spread regionally, mostly affecting duck farms. Average velocity of 10.5 km/week and a peak at 27.8 km/week in mid-December. Transmission declined with culling. Duck farm density and poultry farm proximity were key drivers 👉 www.nature.com/articles/s42...

If you are interested in 🧠 LOOPS this is for YOU. We are curating an article collection on cortico-subcortical interactions in the vertebrate brain. Participating journals include @commsbio.nature.com @natneuro.nature.com @natcomms.nature.com & SciRep. We look fwd to your contributions!!

New paper: Do corals keep their thermal tolerance in nurseries? #CBASS assays show A. cytherea lose then recover, while A. florida retain tolerance=>To inform restoration, screening should be conducted prior to nursery propagation www.nature.com/articles/s42... @uni-konstanz.de @coralku.bsky.social

Decades of captive green sea turtle data reveals no evidence of reproductive senescence despite mortality rates increasing with age. These results contextualize age-specific changes in the life history of sea turtles within the testudine phylogeny. www.nature.com/articles/s42...

The soil bacterium Cupriavidus sp. LA-1 degrades natural pterin and lumazine pigments via xanthine using three unique enzymes: MPT-containing lumazine dehydrogenase, amidohydrolase signature isomerase, and prenylated FMN-dependent decarboxylase. www.nature.com/articles/s42...

The anterior cingulate cortex (ACC) plays a crucial role in regulating tumour growth, local neuronal damage, and the progression of depression in a mouse model of colorectal cancer comorbidity. www.nature.com/articles/s42...

Here, researchers developed Mactop to identify topologically associating domains (TADs), TAD communities, and chromunity from 3D chromatin structure data, revealing their relationships with chromatin accessibility and histone modifications. www.nature.com/articles/s42...

Thumbs and brains coevolved in primates. Across living and extinct species, longer thumbs predict bigger brains, highlighting the neural cost of dexterity. @bananajoker.bsky.social www.nature.com/articles/s42...

Single-dose antiviral drugs consisting of engineered viral receptor-binding domains display immediate and long-acting effects through dual mechanisms of rapid receptor blockade and adaptive immunity induction. www.nature.com/articles/s42...

Integration of a probabilistic reversal learning task aligned between humans and rodents demonstrates concordant behavioural, computational, and neurophysiological measures of cognitive flexibility between species. www.nature.com/articles/s42...

Microbial high-throughput sequencing combined with proteomic and metabolomic analyses reveal that Metabacillus indicus cB07 alters microbial communities and induces settlement of Pocillopora damicornis larvae via key metabolic pathways. www.nature.com/articles/s42...

Atomistic molecular dynamics simulations reveal the mechanism of non-selective cation permeation in the human cyclic nucleotide-gated CNGA1 channel, where hydrated cations traverse a highly dynamic selectivity filter. www.nature.com/articles/s42...

A 3D high-throughput screen in type I collagen is established to score drug efficacy by colony morphology, identifying three antibiotics that re-epithelialize colorectal cancer colonies and enhance chemotherapy response. www.nature.com/articles/s42...

A new study supports Oep80’s role in chloroplast β-barrel assembly, showing that refolded Oep80β binds to the β-signal (β-1) sequences of several substrate OEPs and that conserved C-terminal residues in these β-1 sequences are important for interaction. www.nature.com/articles/s42...

The non-inhibitory serpin Maspin (SerpinB5) directly binds to microfilaments and microtubules in vitro and in cells, acting at the interface between the cytoskeleton and adhesion sites. www.nature.com/articles/s42...

Our editor Laura Rodríguez is attending the Benzon Symposium no. 69 on Protein structure prediction and design, please feel free to talk to her if you want to know more about our journal or our collection on AI in Structural Biology!

🪸Fatty acid profiling & stable isotope analysis reveal selective nutrient incorporation in a mixotrophic #coral (S. pistillata), suggesting conventional methods may underestimate heterotrophy. @urigso.bsky.social, @eco-oce-lab.bsky.social @marleen-stuhr.bsky.social www.nature.com/articles/s42...

A review from researchers in Bialystok, Poland, on the protection of melanocytes in human skin from oxidative stress by e.g. natural compounds. www.nature.com/articles/s42...

A new perspective is out with us :) This time on how Japanese encephalitis virus-based nanotherapeutics can help against Amyotrophic lateral sclerosis www.nature.com/articles/s42...

Analysis across 95 living and extinct primate species demonstrates that longer thumbs predict bigger brains, highlighting the neural cost of dexterity. 👍🧠@bananajoker.bsky.social www.nature.com/articles/s42...

A new review on the challenges of identifying cancer cells in single-cell data, summarizing current computational solutions as well as underexplored features of malignancy. From scientists ‪@sib.swiss‬ www.nature.com/articles/s42...

New (retrospective) @natureportfolio.nature.com cross-journal collection on how microbes can help to reach environmental goals: Microbial strategies to support environmental goals www.nature.com/collections/...

Exogenous addition of glucosylsphingosine affects cellular energy metabolism in SH-Sy5y cell line via changes in mitochondrial function and glycolysis. It also induces an increase in protein ubiquitination with tubulin species affected the most www.nature.com/articles/s42...

Selective ablation of Elongator in a conditional knockout mouse model of amyotrophic lateral sclerosis leads to motor neuron degeneration and reduced levels of nuclear and nucleolar TDP-43 www.nature.com/articles/s42...

DYRK3 kinase interacts with multiple centriolar satellites and ciliary components to regulate axoneme length dynamics in cooperation with DYRK2 www.nature.com/articles/s42...

The authors developed the HybriSeq method for single-cell RNA profiling without involving reverse transcription or microfluids using a target panel of hybridization probes and split-pool barcoding www.nature.com/articles/s42...

This study proposed a method for identifying the host origins for zoonotic pathogens by integrating pan-genome-wide association studies with machine learning algorithms. Its application on the Brucella species revealed diverse zoonotic host origins and potentials www.nature.com/articles/s42...

Mechanistic analysis of the Optineurin LC3-interacting region uncovers how phosphorylation and flanking regions shape SLiM-mediated autophagy interactions through simulations, mutational scans, and quantitative binding assays www.nature.com/articles/s42...

See how phi3T phage shifts Bacillus subtilis cell shape in the absence of SPbeta prophage and alters its fitness - our new publication in @commsbio.nature.com from group of @annadragos.bsky.social together with @bramkamplab.bsky.social www.nature.com/articles/s42...

Co-first author paper with Tina Liu out now in @commsbio.nature.com Our longitudinal fMRI data of child epilepsy patients with occipitotemporal cortex (OTC) resection show deviations from the expected topography in preserved cortex, demonstrating plasticity. www.nature.com/articles/s42...

Single-cell multiomics for analysis of replication timing (RT) and gene expression in early mouse embryos revealed RT establishment at the 1-cell stage, and a link between late-replicating regions and higher gene expression during early development www.nature.com/articles/s42...

Cell-free expression with engineered DNA enables rapid production of bacteriocin cocktails, overcoming antimicrobial resistance and clearing pathogenic infections in animal models www.nature.com/articles/s42...

The authors propose a workflow to detect palladium-doped nanoplastic particles in biological samples combining three complimentary methods, namely inductively coupled plasma mass spectrometry, X-ray fluorescence imaging, and imaging mass cytometry www.nature.com/articles/s42...

A human specific monoclonal antibody binds the C-terminal domain of SARS-CoV-2 Nucleocapsid protein, blocking viral RNA interaction and disrupting condensate formation by interfering with the RNA-binding surface www.nature.com/articles/s42...

TSIT, a novel respirometry method, sensitively assesses mitochondrial function in frozen cardiac tissue, revealing high-resolution respiratory capacity in animal models and human samples with strong translational relevance. www.nature.com/articles/s42...

The study investigates CAR-Treg cells targeting VCAM-1 as a novel treatment for abdominal aortic aneurysm (AAA). Preclinical results show that CAR-Treg cells effectively reduce inflammation and aortic dilation, offering a non-surgical treatment option for AAA www.nature.com/articles/s42...

Quantifying information-theoretic individuality as persistence of information in time reveals the emergence of higher-order organization in evolutionary systems, where groups of species exhibit enhanced collective persistence www.nature.com/articles/s42...

STRaM is an advanced bioinformatic pipeline for handling complex engineered-cell and cell-line provenance. The automated system evaluates similarity index, purity index, editing/mutation index for cell products identification and traceability. www.nature.com/articles/s42...

Morphological and electrophysiological understanding of cerebrospinal fluid-contacting neurons (CSF-cNs) is extended by analysis in the mouse, revealing that they express PKD2L1 and ASICs along with ligand- and voltage-gated channels modulated by metabotropic receptors www.nature.com/articles/s42...

Circadian rhythms gene Per2 regulates microglial ferroptosis through the PPARα-GPX4 axis in SCI, which indicates that Per2 may be emerging as a potential therapeutic target for SCI treatment. www.nature.com/articles/s42...

Multiomics analysis of placental dysfunction defines on interomics networks and identifies disease-specific signatures, illustrating the power of systems biology in understanding obstetric syndromes. @samanthapiekos.bsky.social www.nature.com/articles/s42...

Metagenomic analyses of >1,200 uncultivated marine Autographiviridae genomes reveal their diversity, host range, functional potential, and biogeography, providing key insights into their ecological roles. www.nature.com/articles/s42...

A variational phase-amplitude coupling framework uncovers dynamic brain-heart coordination across sleep stages, elucidating autonomic-cortical interplay and nuanced indices for physiological integrity in healthy and pathological sleep. www.nature.com/articles/s42...

Pseudomonas aeruginosa coordinates several virulence factors – the type 3 and H1-6 secretion systems and the flagellum – on a single cell level using the second messenger cyclic di-GMP, promoting subpopulations with distinct virulence states. @diepold-lab.bsky.social www.nature.com/articles/s42...