End-to-end protein design in the browser through evedesign. Generate and interactively explore designs in 2D/3D and export them as codon-optimized DNA. The underlying open source framework (released soon) is build to easily add new methods, more on that soon. 🌐 evedesign.bio

1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria. www.biorxiv.org/content/10.1...

Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…

hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!

🧪 #RNAsky If you aren’t using RNAcanvas to draw your RNA structures and explore alternative structures, you are missing out! 56 citations in a year, with multiple ones in top journals like Nature, Science & Cell. Easy to use and packed with unique features! Try it! academic.oup.com/nar/article/...

Happy to share our paper in Nano Letters!🧬 We developed programmable RNA nanostructures for detecting cotranscriptionally introduced RNA modifications using nanopores. Big congrats to first authors Iva & Gerardo and thanks to all collaborators! 🔗https://pubs.acs.org/doi/10.1021/acs.nanolett.5c02391

Have you ever wanted to design large and complex ribozymes from scratch? I know I have! We used RNA inverse folding to design synthetic Group II Introns (G2Is) from the bottom up, resulting in highly active #ribozymes that splice in E. coli without proteins! #intron #RNAsky #SynBio 🧬🧵(1/n)

New paper from the lab from Sriram Garg in my group. We introduce a general substitution matrix for structural phylogenetics. I think this is a big deal, so read on below if you think deep history is important. academic.oup.com/mbe/advance-...

I haven't been posting much social media recently, but if there is one thing you read this week it should be THIS: www.pnas.org/doi/10.1073/...

New paper from my group rdcu.be/eoaRr "Trinucleotide substrates under pH–freeze–thaw cycles enable open-ended exponential RNA replication by a polymerase ribozyme" in Nature Chemistry — great collaboration with attwaterlab.uk.

Christmas came early this year! I have been wondering about this for years!

Emancipated Archaea 🦠 Nowadays, H₂-dependent archaea rely on partnerships with organisms that produce hydrogen. But on early Earth, when life began, archaea were probably on their own. So, where did they get the H₂ from? Let’s dig into the science. #Science #OriginOfLife (1/5)

1/10 Today in @science.org in collaboration with the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...

Hello BlueSky! Inaugural post here from the Sternberg Lab. We're excited to share our latest work, in which we teamed up with the @WiedenheftLab to study how DRT9 reverse transcriptases provide antiviral immunity. Here’s what we found: www.biorxiv.org/content/10.1...

Dating Bacteria is hard due to the lack of maxima. Assuming aerobes likely postdated the GOE gave us better resolved ages, but also surprised us, but not Dr Dayhoff, showing O2 use predated its atmospheric rise by 900 Mys and helped oxygenic photosynthesis to evolve. www.science.org/doi/10.1126/...

Here to report UltraSelex which uses single-round selection and ranking algorithm for high-affinity RNA aptamer discovery #RNA #ChemBio #chemsky #drugdiscovery www.nature.com/articles/s41...

Rejoice! RFdiffusion2 just dropped! www.biorxiv.org/content/10.1...

Interested in a #postdoc in #originsoflife research? Are you a geek who loves #RNA, #RNAseq and tinkering, with a background in #biochemistry, #chemistry or #biophysics? Join #bubblelife! Apply now by email (CV + a short motivation letter)! cordis.europa.eu/project/id/1...

#ncRNA molecules are far stranger than you think. We propose that OLE RNA is bacteria's functional mimic of #mTOR, and the Das lab at Stanford proposes OLE RNA penetrates cell membranes! They also find that RNAs we called ROOL and GOLLD form 8-membered nanocages. www.biorxiv.org/content/10.1...

Out now in @NAR_Open ! A #ribozyme can self-integrate into and hydrolyze ss- & dsDNA, offering a new avenue for the development of protein-free genome editing tools, and hinting at the possibility of a pre-translation origin of group II introns (G2Is). 🧬🧵 (1/7) #intron #RNAworld