Excited to share our lab’s new article in Biochemical Pharmacology on PARG as a key regulator opposing PARP functions and its emerging therapeutic potential in cancer. Overview of current PARG inhibitors included. www.sciencedirect.com/science/arti...

Our review article 'PARPs and ADP-ribosyl hydrolases in cancer therapy: from drug targets to biomarkers' is now available online. doi.org/10.1016/j.dn...

A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114! www.nature.com/articles/s41... www.science.org/doi/10.1126/...

RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. A proteomics approach is developed using these domains to map ADP-ribosyl-ubiquitylation sites www.nature.com/articles/s41...