New research - Appendicectomy versus switching to a JAK inhibitor in inducing remission in patients with active ulcerative colitis after biologic therapy failure (COSTA): 1-year results of a multicentre, prospective, cohort study www.thelancet.com/journals/lan... #IBD #GastroSky #MedSky

Twin cities friends: I'll be speaking tomorrow at the Minnesota Center for Philosophy of Science on how AI disrupts the sometimes precarious balance of scientific incentives.

Great article @bilalmohammadmd.bsky.social

I suspect, but cannot prove, that this effect is temporary. A ‘Termination Shock’. H/t to @nealstephenson.bsky.social

The gut's 'sixth sense' microbiome regulating eating behavior in real time, another new path for the gut-brain axis, "neurobiotic," in the mouse model www.nature.com/articles/s41...

The unintended consequences of a gut microbiome transplant www.cell.com/cell/abstrac...

Our new clinical practice update in @aga-cgh.bsky.social offers insights on diagnosing and treating sclerosing mesenteritis — a rare, often asymptomatic condition of the bowel mesentery. 📄Read more here: gastro.org/news/expert-.... #GIsky

Today is #WorldIBDDay! Some recent #IBD related highlights in the journal: 1) Overcoming the challenges of overtreating and undertreating inflammatory bowel disease www.thelancet.com/journals/lan... #gastrosky #ibdsky #medsky

The Minneapolis VA Medical Center got it’s CMS rating today; based on mortality, safety of care, readmission, patient experience, and access. We are one of 2 (out of 19) Twin cities hospitals to get the highest 5-star rating. The VA is outstanding- but under threat.

My parasocial relationship with Ed Yong really helped me through the pandemic. Excellent journalist with a well-deserved Pulitzer.

My question-is polyethylene glycol an emulsifier as well?

The emulsifiers that are best to be avoided in foods www.wsj.com/health/welln... like polysorbate 80, xanthan gum, guar gum, carboxymethylcellulose

A concern about medical A.I. is that its reliance by physicians could lead to degradation of performance. Here is one such example of de-skilling with GI doctors and colonoscopy for detection of polyps (preprint) papers.ssrn.com/sol3/papers....

An estimated 300,000 children globally are expected to lose access to a nutrient-dense peanut butter that’s specially formulated to treat severe acute malnutrition.

As 2024 draws to an end, several significant publications have advanced our understanding of inflammatory bowel disease treatment. Key studies offer important insights and a few are worth highlighting... ...continue reading at --> substack.com/home/post/p-... #IBDSky #GISky

Congratulations Bill!

IFX+AZA vs AZA in ASUC pts who responded to IV steroids (ACTIVE trial) - n=64, bio-naive pts - steroids stopped after d7 (combo arm), d14 (AZA arm) - IFX dose escalation to 10mg/kg allowed - no deaths or colectomy - IFX/AZA had lower rates of "failure" by week 52 Practice changing? #IBDSky #MedSky

Medicine focuses a lot on the question “will this help my patient” but not on the question “when will it help my patient.” The latter becomes important as we age. We’ve developed a “time-to-benefit” tool on eprognosis.ucsf.edu to help answer this question. Here is a snapshot #MedSky #FOAMed #meded

That’s my guy! Good to see Bilal settling in at Colorado but we miss him here in Minnesota.