Transient protein phosphorylation promotes disease tolerance to sepsis https://www.biorxiv.org/content/10.64898/2026.06.09.731055v1

How are longevity and immunity to severe infection connected? The answer lies in disease tolerance. Out today in @cp-immunity.bsky.social, we preview an exciting breakthrough by Triana-Martinez et al. on how p16High immune cells protect the host and promote healthy aging. 🧵 (1/5)

Why do organs fail during #Sepsis when there is little evidence of irreversible tissue injury? In our new preprint, we show this isn't random damage—it's an active, regulated metabolic shutdown. Sepsis triggers a "torpor-like" survival state that must be tightly controlled. 🧵 (1/12)