Henrik Salje
@hsalje.bsky.social
📤 739
📥 99
📝 5
Infectious Disease Epidemiologist at University of Cambridge
reposted by
Henrik Salje
Chantal Vogels
9 days ago
📢New preprint on the impact of dengue virus genetic diversity on inhibition by Wolbachia 🦟🦠🧬 Project led by Afeez Sodeinde,
@emiliefinch.bsky.social
, and
@keli5734.bsky.social
! ✨ Key findings in thread below 👇
www.biorxiv.org/content/10.1...
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Heterogeneity in inhibition of genetically diverse dengue virus strains by Wolbachia
The release of Aedes aegypti mosquitoes transinfected with the virus-inhibiting Wolbachia bacterium has the potential to reduce the burden caused by dengue virus (DENV). However, the robustness of thi...
https://www.biorxiv.org/content/10.1101/2025.09.18.677129v1
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reposted by
Henrik Salje
Alex Keeley
about 2 months ago
🧵 Our paper out today in
@naturemedicine.bsky.social
www.nature.com/articles/s41...
On development of
#StrepA
#Immunity
over life course in
#TheGambia
raising hope for
#vaccines
on the horizon 1/
#Immunosky
#IDsky
#MicroSky
#globalhealth
.
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https://www.nature.com/articles/s41591-025-03868-4
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reposted by
Henrik Salje
Arinjay Banerjee
4 months ago
🚨 Nipah virus poses a future
#pandemic
risk. New cases in Kerala, India further highlight the need for a One Health approach. Read more in our recent interdisciplinary and multi-institutional collaborative article now published in @NatureMicrobiology
#LZCI
:
www.nature.com/articles/s41...
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A One Health approach to understanding and managing Nipah virus outbreaks - Nature Microbiology
In this Perspective, Yadav et al. discuss NiV outbreaks, transmission cycles and the role of reservoir and bridging hosts. They also discuss a One Health approach to mitigate the risks of NiV epidemic...
https://www.nature.com/articles/s41564-025-02020-9
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reposted by
Henrik Salje
Simon Cauchemez
8 months ago
Serological data provide key insights on pathogen circulation. We introduce a new R package, Rsero, which is a pipeline to store and analyze age-stratified sero data, estimate the history of pathogen circulation and compare different transmission models.
journals.plos.org/ploscompbiol...
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RSero: A user-friendly R package to reconstruct pathogen circulation history from seroprevalence studies
Author summary Antibodies are immune markers of past infections. Seroprevalence studies that characterize the seropositivity status in the population have been used for decades in epidemiological stud...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012777
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reposted by
Henrik Salje
Department of Genetics, University of Cambridge
9 months ago
Phylowave; The latest framework developed by researchers to identify more infectious variants of viruses or bacteria, including those responsible for flu,
#COVID
and whooping cough. "A vaccine can be specifically targeted against these variants, to make it as effective as possible" 🔗
rdcu.be/d5pFu
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8
1
reposted by
Henrik Salje
Pathogen Dynamics Unit
9 months ago
Great way to start the year! A paper in
@nature.com
by our amazing @noemie presenting a way to use sequences to identify pathogen lineages, quantify their fitness, and identify potentially important genes/snps . Works across bugs, even with minimally and biased set of sequences.
add a skeleton here at some point
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reposted by
Henrik Salje
Pathogen Dynamics Unit
9 months ago
Great way to finish the year! Paper by our
@huangat.bsky.social
in
@pnas.org
showing that relying on seroconversions in cohorts will usually lead to horribly biased
#dengue
incidence estimates whereas models relying on age data from local hospital typically robust.
add a skeleton here at some point
1
9
5
Really excited by the creation of this new Unit with
@ksbakes.bsky.social
and
@virologyhouldcroft.bsky.social
working on the emergence, spread and control of infectious diseases at the University of Cambridge
add a skeleton here at some point
9 months ago
0
14
5
reposted by
Henrik Salje
Dr. Rowan Durrant
10 months ago
Huge thanks to my supervisors Katie Hampson and Christina Cobbold, examiners
@davidlrobertson.bsky.social
and
@hsalje.bsky.social
and convener Louise Matthews!! And everyone else at UofG and beyond who have made the last 3.5 years an amazing time 😁🎉
add a skeleton here at some point
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1
reposted by
Henrik Salje
Department of Genetics, University of Cambridge
10 months ago
We are very proud to share that
@hsalje.bsky.social
has been awarded an
#ERC
Consolidator Grant 🎉 He will be exploring how host, immunity and mosquito factors combine to determine the evolving fitness of the
#dengue
virus 🦠
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Could not be more deserved. Congratulations again Noémie.
add a skeleton here at some point
10 months ago
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#Measles
antibody dynamics are highly predictive. Knowing only a future mum’s titre, we can predict how the infant will respond to vaccine much later. We also see vaccine failure linked to csection birth - maybe due to way microbiome develops. Important these infants get 2nd dose
t.co/MqxTtuIHTH
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Dynamics of measles immunity from birth and following vaccination - Nature Microbiology
Measles remains a major threat to human health despite widespread vaccination. While we know that maternal antibodies can impair vaccine-induced immunity, the relative contributions of pre-existing im...
https://t.co/MqxTtuIHTH
over 1 year ago
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2
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reposted by
Henrik Salje
Megan O'Driscoll
over 1 year ago
New work led by Wei Wang characterises the dynamics of measles immunity in infant&child cohorts in China.
@hsalje.bsky.social
www.nature.com/articles/s41...
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Dynamics of measles immunity from birth and following vaccination - Nature Microbiology
Serological data modelling informs on immune interference from maternal antibodies on measles vaccine responses in infants and children.
https://www.nature.com/articles/s41564-024-01694-x
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Congratulations to our amazing DR. Megan O’Driscoll
@meganodris.bsky.social
on successfully passing her PhD viva! State of the art in infectious disease serology. Thank you to Michael White and Stephen Baker for being excellent examiners.
over 1 year ago
0
3
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We’re hiring!! postdoc and research assistant (with potential for PhD) positions on mathematical modeling of infectious diseases at Cambridge (UK). Mainly of arboviruses including with longitudinal cohorts, disease mapping and models applied to multiplex serology in Africa.
jobs.cam.ac.uk/job/44461/
almost 2 years ago
0
3
3
reposted by
Henrik Salje
Oscar Cortes-Azuero
almost 2 years ago
Excited to present our poster on the genetic diversity of Nipah virus later today at Epidemics9 - Come say hi at poster P2.167! 🦇🧪#EpiSky
@hsalje.bsky.social
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2
reposted by
Henrik Salje
Jeremy Kamil
almost 2 years ago
🧪Yup. Looks like you can atone for original antigenic sin. As with all learning, repetition is key 🥲 (The sky ain’t falling. Imprinting is real, but reports of the immune system’s demise were premature.) h/t
@thelonevirologist.bsky.social
www.nature.com/articles/s41...
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Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting - Nature
Exposure to early variants of SARS-CoV-2 results in immune imprinting in mouse models and in humans, reducing neutralizing antibody titres against Omicron variants, which could be mitigated with multi...
https://www.nature.com/articles/s41586-023-06753-7
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reposted by
Henrik Salje
Lewis C. E. Mason
almost 2 years ago
The evolution and international spread of extensively drug resistant Shigella sonnei. The international outbreak (England, France, Belgium, USA, Australia) was ciprofloxacin, azithromycin, and ceftriaxone resistant - three of four WHO recommended antibiotic treatment options for shigellosis. 🖥️🧪🧬🦠🧫
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The evolution and international spread of extensively drug resistant Shigella sonnei - Nature Commun...
An increase in shigellosis cases among men who have sex with men in the United Kingdom has been linked to an extensively drug-resistant strain of Shigella sonnei. In this genomic epidemiology study, t...
https://www.nature.com/articles/s41467-023-37672-w
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