An Early View: A new review by Prof Hodgson, Prof Foulkes, Prof Maher, and Prof @clare-turnbull.bsky.social traces the evolving landscape of inherited #cancer susceptibility, from tumor suppressor genes to polygenic risk scores. It highlights how genomic tools are reshaping treatment and detection.

📣New from @clare-turnbull.bsky.social & co! 📄Availability of benign missense variant “truthsets” for validation of functional assays: Current status and a systematic approach

"Media coverage and PATHFINDER2: hype, simplification, and free advertising". Commentary on new GRAIL Galleri study published in: @thelancetoncol.bsky.social thelancet.com/journals/lan... From @mgtmccartney.bsky.social @paulpharoah.bsky.social, Sullivan,Houlston,Aggarwal,Schuh,Hogarth,Callister

See our new paper in @ajhgnews.bsky.social : Validating data from multiplex assays of variant effect: A CanVIG-UK national survey of NHS clinical scientists Explores blocks to implementing MAVE data into clinical variant interpretation ‪@varianteffect.bsky.social‬ authors.elsevier.com/a/1lDFkgeXDyy6

Very honoured. Our paper was voted seventh in the annual top ten for the @bjgp.bsky.social. Working in clinical cancer genetics, we wanted to provide information for women with a family history of breast cancer regarding additional BC risk presented by taking HRT (who are often warned off).

On the fifth anniversary of Brexit, 2016: We'd be better off with Brexit 2016: The sun has risen on an independent UK 2023: Brexit has failed 2023: We were more competitive in the EU 2024: Our democracy feels dead End this economic self harm, rejoin the EU

2025: Emily Thornberry wonders whether the EU wants the UK to rejoin the EU, suggesting they don't 2023: "UK should rejoin EU to ‘fix’ Brexit, says Ursula von der Leyen" If you're only YouTube, give this a like and subscribe youtu.be/kNGDpw2rJQc

NEWS 📰 : Lynch Syndrome affects 175,000 people in England but only 5% know they have it. ICR's Professor Clare Turnbull (@clare-turnbull.bsky.social) explains the importance of routine genetic testing to prevent cancer cases. Read more ⤵️

Never forget how much responsibility Merrick Garland has for Donald Trump’s second presidency and total evasion of legal accountability.

We used cancer phenotype sex-specificity to enable more unbiased penetrance estimation of SMARCA4 PVs for SCCOHT tumours in the UKBiobank cohort and observed a 62% deficit of SMARCA4 PVs in females compared to males. Just published in @GIMJournal @UKCGG