Shout out to Fishbone, who was singing to my white-college-boy ass back in the early 90s about fascism. Not something I ever thought about growing up, and they were trying to get me to see it.

My ride share car smells like air freshener and pot. Reminds me of the summer I lived in a house with six band mates and there was a cinnamon air freshener in the bathroom and the keyboard player came out and said “Mmm cinnamon dump!

I've release a new user interface for mdrepo.org, an open repository of molecular dynamic simulations for proteins, written in Elm (specifically Elm Land). The original version used React/JS and was slow and failed with exceptions. The Elm version should have zero runtime exceptions. #elm-lang

Tried to call my step-dad and got his voice mail with the message recorded by my mom, who died in June.

A friend shared a lovely Dijkstra essay. It's short enough to read in a few minutes, and is damning of the current attempt to replace our brains with AI generated writing and vibe coding. www.cs.utexas.edu/~EWD/transcr...

I've become increasingly disappointed my publisher, @oreilly.bsky.social, leaning so heavily into vibe coding. They canceled my Rust course in which I attempt to methodically teach how to learn Rust by writing it oneself. They fired the really good acquisition editors who brought me on board.

A friend would ride with his mom to drop his sister off for piano lessons. Every time, his mom asked him if he'd like to take lessons, too. Every time, he said no. One day, he decided he would say yes the next time his mom asked. She never did, and he never studied the piano.

I don't understand the government taking 10% of Intel profits. Like, isn't that what taxes are supposed to be?

My one food service experience was 27 years ago at a Cracker Barrel in Lewisville, TX, my last semester in college after my folks kicked me off the payroll after a huge fight over my girlfriend.

I like Weird Al but not weird AI and this is a very confusing time for me.

My retirement plan is somewhere between outfitting a Tuff Shed or cliff-diving a la Midsommar with the backup head hammer.

My current project is continued support and development on this. It's really cool.

Trying to reconcile how all positive change had to be incremental, studied in perpetuity & ultimately stalled with ‘how are we gonna pay for that?’ but dismantling everything was done quickly, ham-fistedly & with total disregard for cost of money and lives & no institutional guardrails mattered.

My job at the Univ. of Arizona has been funded by the NSF and NIH. The money runs out pretty soon, so I’m seeking a new role. #Python #Rust #Elm #Bioinformatics

My first book, Tiny #Python Projects (Manning, @manningbooks.bsky.social, 2020), has been translated into #Russian.

I found the #Rust game engine #Macroquad very easy to use in making this little animation of bouncing balls.

Can't stress-eat if I don't start stress-baking.

Her: I don't like these pants. They're too big. What do you think? Me thinking "This is a trap. Don't answer." Her: I should probably change. What do you think? Me: I agree. They're too big and you should change. Her: I can't believe you don't like my pants.

I'm releasing a fun little #Rust tool called "readr" that will print file/STDIN to the screen slow enough to read, kind of like how computers all seem to work in the movies. FWIW, I was exploring async programming with tokio. crates.io/crates/readr

I usually talk about my work in #Rust, but I've also done a lot with #Python. The GitHub repo for my first book, Tiny Python Projects (Manning, 2020), has now hit 2.5K forks! You can find all the videos on YouTube. github.com/kyclark/tiny...

I've always thought "Hot Water Burn Baby" would make a great band name.

Does anybody in #bioinformatics need a #Rust program to convert Stockholm format into FASTA? I'm using this to split multiple sequence alignments in an STK file into separate FASTA files. github.com/TravisWheele...

Here's the link to my @oreilly.bsky.social #Rust course on Monday. If you are a university student, it's very likely that school's library has a subscription to the O'Reilly Learning platform, so it's free to dip in! learning.oreilly.com/live-events/...

The 0.7 version of our #bioinformatics #Rust crate Sufr for parallel creation/querying of suffix arrays includes a deeper test suite that found many bugs I fixed. crates.io/crates/sufr

If this dune's Arrakeen, Don't come a-knockin'.

I've pushed a new version of Sufr, a #Rust implementation for fast parallel creation and searching of a suffix array. This release includes support for spaced seeds and searches requiring almost no RAM. crates.io/crates/sufr

I'll be giving a 4-hour introduction to #Rust #programming with @oreilly.bsky.social on Feb 3 2025. learning.oreilly.com/live-events/...

BRB. Busy beweeping my outcast state.

I've been very hesitant to use AI assistants for coding. I went back and forth with ChatGPT over a regex to find a string comprised only of 0 or 1 and starts and ends with 1. It confidently gave me two incorrect patterns that would have messed up my code. My answer is "^1+0[01]*1$". I am vindicated.

Is there a good piano arrangement for Holst's Planets?

v0.5 of my #Rust #bioinformatics crate to create/query suffix arrays includes multi-threaded search. with 12 CPUs, I can load 3GB human genome into memory in 38s, find 1M 15-mers in 1.5s w/max memory use of 23G. Low-mem search using disk access takes 82s w/3.5G RAM. crates.io/crates/sufr

Today is Transgender Day of Remembrance. Each year, the trans community loses too many lives, especially trans women of color, to hate and violence. More than ever, we must stand by our trans family and support them, hold space for them, and insist the scapegoating and targeting stop. Now.

I actually look at the #ASCII table all the time, so I wrote a little #Rust program to show it and help me convert between characters and codepoints. I had a CS professor who memorized the ASCII table, so I'll one day grow this out into a game interface to quiz you on values. crates.io/crates/asciir

See version 0.4 of #Rust #bioinformatics code "sufr" (and "libsufr") for creating suffix/LCP arrays. Fixes a bug reading the arrays for very large inputs and implements a fully in-memory search that can be reduced by a maximum query length or use disk-based/low-mem search. crates.io/crates/sufr

The 0.3 release of the #Rust #bioinformatics crate "sufr" for creating and searching suffix arrays is out. Now handles soft-masked sequence and ambiguity codes. crates.io/crates/libsufr

I feel I'm a decent coder who's superpower is that I've embraced languages like #Rust and #Elm with strict compilers that catch dumb mistakes and I write tests to help me understand my code and keep me from breaking stuff that used to work.

New low-memory version of #Rust #bioinformatics suffix array crate "sufr" dropped. On my MacBook ARM 8 cores/16GB RAM, it creates fully sorted SA/LCP arrays for T2T chr1 in 24 sec using 1.15GB RAM max. Entire human genome finishes in 14 min, max 5.7GB RAM. crates.io/crates/sufr

I've made an initial release of "sufr," a #Rust #Bioinformatics tool for parallel construction of suffix arrays. crates.io/crates/sufr

My @oreilly.bsky.social book Command-Line #Rust has been translated into the Korean language.

Update your address books, folks. I can now be found working with @wheelerlab.org! I'm rejoining the University of Arizona after a four-year absence.

Almost 8 weeks of looking for a job. I've lost count of the applications and rejections. I've completed a second application that asked for essay-length responses stretching to 15 pages of writing. As Beckett said, "I can't go on. I'll go on."

@oreilly.bsky.social sent me a few copies of my updated Command-Line #Rust book. The first version came out in 2022, and I wanted to freshen up the examples to reflect changes in underlying crates and the language that happened over the last two years.

I've been let go from my company and am looking for my next gig preferably using #Rust or #Python, hoping to stay in #bioinformatics.

At the grocery store and "Never Gonna Give You Up" is playing and my wife is trying to remember the term "Rick Rolling" and asks me about "Rick Astley Bombing" and I'm not even sure I married a Gen Xer anymore.

I've release commr, a #Rust version of "comm" that inverts the meaning of the "-123" flags from "suppress" column to "show" column because I find that difficult to remember. Plus, my tool is just cool. crates.io/crates/commr

I've released an initial version of "cutr," a #Rust version of "cut" that respects escaped input field delimiters and attempts to improve over the BSD/GNU versions of "cut." I have some more work to do, but I find this tool useful already. crates.io/crates/cutr

I love using my own #Rust tools and finding ways to improve them. I just released a new version of csvchk for checking delimited text files. Specifically, it won't die with on the first file error but will print to STDERR and move on. crates.io/crates/csvchk

O'Reilly has published a Korean version of my book, Mastering #Python for #Bioinformatics. www.aladin.co.kr/shop/wproduc...

O'Reilly has published a Japanese version of my book, Command-Line #Rust. www.oreilly.co.jp/books/978481...

I'm very happy to hold the complex Chinese translation of my book Command-Line #Rust. Thanks, @oreilly.bsky.social!