Biocatalysts can build big molecules. A team at Merck & Co. developed a suite of enzymes that stitch together their oral PCSK9 inhibitor enlicitide. My latest for @cenmag.bsky.social cen.acs.org/pharmaceutic... #chemsky

There was a mass shooting this morning at Indiana University that has left nine injured. The Indiana Daily Student has been facing pressure by Republicans and school administrators to shut down the print edition all year. Why isn't Donald Trump or legacy media corps reporting about this huh?

I found a cloned Cobalt theme so my brain is fully convinced it’s RStudio still—guess that’s all it takes!

Uhhh is that psilocybin on the chalkboard?

Turns out I just needed to make the page wider 🙃

RStudio has given me enough trouble that I’m finally shopping around for another IDE. It’s tough to say goodbye to all the built-up muscle memory with it, but I can only take so many crashes while I prepare for an important meeting. Positron is seeming fine so far but it’s… just VSCode?

Being a patient in like 7 different vaccine clinical trials did this for me. It’s nice for medicine to be less intimidating!

This is an Indiana thing?? I had no idea those free Pizza Express breadsticks were a regional delicacy

I love plotly, it works so well with Quarto! And putting plotly things next to ggplot graphics always gives me the result I want!!!!!

Damn, good thing I never update it

IU!!!!!!!

Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version? I made an app you might like: adamkucharski.github.io/pdf2plot/ It all started a few years ago... 🧵

Love it when a developer of a tool I use almost daily just up and decides the input files are -f and not -i anymore

Honestly wild that 2.5 million lives saved is the most contrarian number that Ioannidis managed to pull out of his random number generator. ONLY that many?!

Finally

It’s nuts, and Yan Li-Meng is broken, but she bears responsibility for the path she chose to venture down.

New paper out: An archaeal genetic code with all TAG codons as pyrrolysine: www.science.org/doi/10.1126/...

4 x 4L bottle boxes are the GOAT of moving

This is such a neat idea from the @narayanlab.bsky.social and the @hartwiggroup.bsky.social now in #JACSasap fooling enzymes with a removable binding ligand to accept non-native substrates #ChemSky

Larry Tesler, inventor of the cut, copy, and paste commands, dies at 74

The thing I love about taxonomy is that it never changes and everyone agrees on names for everything!!!

Do you really need to stir your reactions? How do you know?

"oh nothing matters because mr. trump won't let it matter" shut up

Getting into homeownership is really making me much more of a just-call-customer-service person than I expected

A lot of people will believe this shit! Lots of suburban and rural folks truly think that US cities are literal war zones. They could easily be convinced that if they visit them and find them pleasant and safe that it was all Trump’s doing rather than them being fine the whole time.

ACS 1996 is a fine starting point but imo you should probably manually tailor your ChemDraw object settings to whatever kinds of molecules you work most with. I worked with polypeptides through my PhD and I really didn’t like how its skinny bonds made these long molecules look like chicken scratches

Oh so it does have phd level intelligence

Trump take video game

Hope the estate of Henrietta Lacks is on this

Baby’s first Nanopore run

The 2010 paper claiming arsenic-based life has been retracted by Science today. 🧪

Follow @wario64.bsky.social and repost for a chance to win 1 of 15 Steam codes for Dungeons & Dragons Neverwinter Nights 2: Enhanced Edition courtesy of @aspyr.com. Giveaway ends on July 20th, 6 PM PT game is available now on PC and consoles store.steampowered.com/app/2738630/...

Pedagogy is often worse at more elite institutions, even. Place like Indiana University have faculty that publish in J Chem Ed. More elite institutions just wanna hire more faculty who’ll publish in CNS, their teaching skills be damned.

Something anybody who’s set up parallel heterogeneous catalysis experiments—or reactions limited by gas transfer rates—has probably run into at some point. Good to see this phenomenon highlighted!

Even worse is cafes that make their own oat milk. Oatly is good, just buy that! The only two lattes I’ve ever tossed because they were so bad had homemade oat milk.

My team and I at the Crowd Counting Consortium (@[email protected], Soha Hammam, & Chris Shay) have a new piece out: wagingnonviolence.org/2025/06/amer.... In it, we show that through May 2025, the size and scale of anti-Trump protests have dwarfed those in 2017. 🧵

Fun times with @nanoporetech.com ahead!

Loving the new macOS design language

not the main issue here but i'd really appreciate it if democratic politicians spoke out in support of big-city life and culture with the same energy and reverence that all politicians have for small towns los angeles is "real america" and so are all the other big cities the president hates

My third video game midnight release: Halo 3, Super Smash Bros. for 3DS, and now the Switch 2. Surprisingly well organized!

Babe it’s such a good deal, I’ll find a use for them I swear

There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd. It's not just budgets but research, institutions, expertise, and training the next generation.

This and tiny Monsters saved my jet lagged ass

Some things that the US could take from Japan, a list as I think of them:

MilliporeSigma to institute a tariff surcharge on May 5

The average American has three friends

This why these folks’ “sincere concerns” should never be taken seriously. Oh, you’re “concerned” about mRNA vaccines and would prefer conventional protein-based vaccines? Here’s one right here. Now you’re “concerned” about clinical trials of the protein vaccine? Fuck off!

Insanity!