Interested in T cell immunity in TB? Check out our new pre-print on antigen-agnostic identification of generalisable human in vivo Mtb-reactive T cell responses: www.biorxiv.org/content/10.1... with @qimmuno.bsky.social & @innate2adaptive.bsky.social

Really pleased to share collaborative project led by @emilybethwong.bsky.social & 1st author @maphemthembu.bsky.social A careful dissection of dysfunctional immune responses in ART-naive HIV infection. TL:DR bronchoalveolar ≠ blood responses #HIVSky #IDSky #ImmunoSky www.cell.com/iscience/ful...

Also out now.. after peer review, our analysis of blood transcriptional biomarkers of acute respiratory viral infection leveraging the SARS-CoV-2 human challenge model: www.nature.com/articles/s41...

🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨 We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB. Lead author @gushamilton.bsky.social #TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan... Thread 👇 (1/8)

Presented interesting paper in @innate2adaptive.bsky.social journal club today. Monocyte-T cell doublets in blood of TB & dengue pts - single cell transcriptional profiling: - activated cells - T cell-like monocytes & monocyte-like T cells Unclear functional role & if 100% not artefact #Immunosky

📣 We are hiring! Postdoc opportunity in Quantitative Immunology at University College London. . 🔬 Develop computational approaches to discover clonal and functional T cell determinants of protection against Tuberculosis. Fully funded 2-year position. 🗓️ Apply by Dec 10 www.ucl.ac.uk/work-at-ucl/...

More evidence of immune cell (macrophage) -> stromal cell (fibroblast) inflammatory communication to alter organ function (deleteriously, in this case) #ImmunoSky www.nature.com/artic...