This manuscript was chosen as the NIDA IRP paper of the month 😎🙏🙌 irp.nida.nih.gov/featured-pap...

Our pub describing an approach to quantify the head twitch response in mice from video recordings using the open-source machine learning-based toolkits DeepLabCut and SimBA is out now in ACS Pharm Trans Sci! pubs.acs.org/doi/full/10.... #psychedelics #HTR #machinelearning

Out now: Psychedelic-like effects induced by DOI, LSD, and psilocybin in male and female C57BL/6J mice Check it out 👇 link.springer.com/article/10.1... #psychedelics #HTR

Rapid, open-source, and automated quantification of the head twitch response in C57BL/6J mice using DeepLabCut and Simple Behavioral Analysis https://www.biorxiv.org/content/10.1101/2025.04.28.650242v1

Excited to announce our preprint using machine learning-based toolkits to quantify the head-twitch response in mice. www.biorxiv.org/content/10.1...

Catch us on Friday at the virtual ISRP meeting! www.isrpsych.org/conferences 12:10 PM - 12:25 PM EDT 9:10 AM - 9:25 AM PDT Michael Baumann 3:15 PM - 3:30 PM EDT 12:15 PM - 12:30 PM PDT Grant Glatfelter #DMT #4MeOMiPT #psychedelics

Toxicological evaluation, postmortem case descriptions, and pharmacological activity of N,N-dimethylpentylone and related analogs doi.org/10.1093/jat/...

🚨 Save the Date! 🚨 I'm speaking about 4-HO-MiPT analogs at the upcoming International Society of Research on Psychedelics (ISRP) virtual conference on March 7, 2025! 🌐 ✨ 24 presentations ✨ Register here today - www.isrpsych.org/store #Psychedelics #PsychedelicResearch #ISRP2025

New pub in ACSChemNeurosci comparing 5-HT1A & 5-HT2A activities & target profiles of #5MeODMT analogs Variable activities at 1A/2A modulated #psychedelic -like effects in mice, and 1A preferring hybrid 1A/2A drugs may have attenuated subjective effects in humans. pubs.acs.org/doi/full/10....

A recent review of 5-HT2A receptor SAR from Dr. Dave :)

Dispatch From the DEA: DOI and DOC on Trial As Scientists Challenge Psychedelic Scheduling Bid Here, @jackgorsline.bsky.social and I provide the latest from hearings over DEA’s plan to place these two psychedelics in Schedule I of the Controlled Substances Act. psychedelicalpha.com/news/dispatc...

1) Drug discovery, medication development, new psychoactive substances, preclinical research 2) SAR study on 5-MeO-DMT analogs that should hopefully be out soon 🤞 3) I went back and rewatched "Dirty Pictures" recently, which I highly recommend for anyone who hasn't seen it

Check out our new publication on the pharmacological characterization of novel, "prophetic" nitazene synthetic #opioids - some of which were found to be more potent than #fentanyl! www.sciencedirect.com/science/arti...

Release from Usona Institute about our collaborative study of the psychedelic -like effects of norpsilocin analogues: www.usonainstitute.org/updates/uson...

A really nice synopsis of our recently published study on lisuride vs LSD from Derek Lowe for "In The Pipeline" 😎 www.science.org/content/blog...

A really nice synopsis of our recently published study on lisuride vs LSD from Derek Lowe for "In The Pipeline" 😎 www.science.org/content/blog...

Release from Usona Institute about our collaborative study of the psychedelic -like effects of norpsilocin analogues: www.usonainstitute.org/updates/uson...

Thrilled to share the final product for an excellent collaboration with A. Sherwood & co at Usona Institute 😎. Extending norpsilocin by a single methyl group to N-ethyl is sufficient for psychedelic-like activity in mice. Full story & SAR linked below: pubs.acs.org/doi/10.1021/...

Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone www.nature.com/articles/s41...

Excited to announce that I'm being promoted to a full-time federal employee in the DDRU to continue research on new psychoactive substances for the foreseeable future 🙌. Grateful for all of the support from NIDA IRP and Mike Baumann to make it possible 🙏

The chronobiologist in me wants to highlight the importance of the Dictionary.com word of the day yesterday. Zeitgebers matter for all biological research. Many ignore the influence of zeitgebers in biomedical research - contributing to the replication crisis and misleading future research.

The important psychedelic and other research Roland lead at BPRU and his dedication to science will never be forgotten - RIP. His team at BPRU changed my life forever by giving me a shot to work there early in my career. TY 💚 hub.jhu.edu/2023/10/18/r...

Finally made it to bluesy thanks to @alexkwan.bsky.social! Follow me for updates on and discussion of research regarding the pharmacology of psychedelics, opioids, cannabinoids, stimulants, and melatonergic drugs.