Rainy morning in the park. Spring has truly sprung on Vancouver Island. #photography #nature #flowers #EastCoastKin #bloomscrolling #crocus #scape #VancouverIsland #PhotographersOfBlueSky

Camellia #Winter #flowers #bloomscrolling

#ecology #health #publichealth #ASD #pediatrics #microbiome #education #SDGs #neurology #neuroscience #ecotoxicology #biomonitoring Co-exposure to lead (Pb) and cadmium (Pb) is associated with increased severity of social deficits in children with autism. . pmc.ncbi.nlm.nih.gov/articles/PMC...

In March I’m simply looking forward to sunshine and flowers #GardensHour 🌱 #Gardening #UKGardening #FlowerFeed

#SDGs #publichealth #health #exposome #aging Poor people tend to have higher levels of bisphenol A in the liver, kidneys, brain, and breast tissue, due to canned food consumption. BPA increases the risk of heart disease, cancer, diabetes, kidney disease, dementia, elevated triglycerides, PCOS.

#ecology #health #agedcare #SDGs #sustainability The mixtures of pollutants contributing to breast cancer risk vary by - geographic region, - birth year, - and subtype of cancer. Preventive healthcare AI needs to get better at tailored human biomonitoring and identifying sources of exposure. .

To mark meteorological spring, I went hunting for 10 shades of crocus for #TheWinter10 in the grass outside my house #WildflowerHour 🌸

#cheeringupmondays Budding up nicely Rosa ‘It’s A Wonderful Life’, Hellebore hybrid Viv Lucrezia, Vinca Major, The Green God is quietly pleased. Have a good week everyone, take care. 🌱

#ecotoxicology #bioinformatics #neurology #health #cells #cellbiology #toxicology #aging Rotenone induces disassembly of the Golgi apparatus. . www.sciencedirect.com/science/arti... . DDT plus PCBs (Aroclor-1221) damage mitochondria and Golgi complex. . hero.epa.gov/reference/22... .

#microbiome #MASLD #health #SDGs The neonicotinoid pesticide nitenpyram damages the intestinal mucosa, disturbs intestinal flora, and increases Desulfovibrio gut microbiota. Excessive H2S produced by Desulfovibrio causes non-alcoholic steatohepatitis. . www.sciencedirect.com/science/arti...

#health #ecology #agedcare #publichealth #ecotoxicology #hepatology (PAHs and other pollutants increase cholesterol.) Positive association between urinary OH-PAHs (exposure to polycyclic aromatic hydrocarbons) and dyslipidemia (triglycerides, cholesterol) . www.sciencedirect.com/science/arti...

#health #ecology #agedcare #publichealth #exposome #menopause #womenshealth #ecotoxicology #occupationalhealth #gerontology #SDGs #oncology #epidemiology #NCDs NO2 and PCB153 were the air pollutants that contributed most to an increased risk of breast cancer. . link.springer.com/article/10.1...

According to old tradition, daffodils bloom around 1st March in honour of Saint David, the patron saint of Wales. His feast day falls on this date and coincides with the beginning of meteorological spring. #StDavidsDay #FolkloreSunday

#health #Alzheimers #agedcare #publichealth #SDGs #ecotoxicology p-tau217 (tau phosphorylated at Thr217) is a blood-based biomarker for Alzheimer's disease. Phosphorylation at Thr217 is catalyzed by Cdk5 and GSK-3β. Cdk5 and GSK-3β are activated by mixtures of environmental pollutants. .

#PFAS #publichealth #TNBC #health #ecotoxicology #exposome #SDGs #oncology #womenshealth F-53B stabilizes HIF-1α protein levels. F-53B (PFAS, forever chemical) accelerates triple-negative breast cancer progression . www.sciencedirect.com/science/arti...

#gastroenterology #publichealth #SDGs Significant increase in IL-8 caused by chlorpyrifos Advanced integrated human in vitro approach to explore gut-brain barrier interactions with gut microbiota metabolites and pesticides (chronic dietary pesticide residues) www.sciencedirect.com/science/arti...

#publichealth #gastroenterology #SDGs Aniline is a widely distributed environmental pollutant. Aniline causes downregulation of tight junction proteins ZO-1, occludin, and claudin-1. shortened small intestine length, increased TNF-α, IL-17, and CD68. . www.sciencedirect.com/science/arti...

#neurology (Tubulin in the brain is reduced by mixtures of pollutants.) Prominent changes in tubulin expression levels in the hippocampus and prefrontal cortex. Associations between a dysfunctional microtubule cytoskeleton and neuropsychiatric illnesses . onlinelibrary.wiley.com/doi/full/10....

Currently in the garden #sixonsaturday #flower #gardening #bloomscrolling

#health #agedcare #ecology #publichealth #neurology #SDGs #ecotoxicology #Alzheimers The neurotoxic organophosphate insecticide chlorpyrifos is one of the pollutants contributing to the risk of Alzheimer's disease. Chlorpyrifos damages microtubules in the brain. . academic.oup.com/toxsci/artic...

#health #agedcare #ecology #SDGs #ecotoxicology #NCDs Tau protein stabilizes microtubules in the brain. Detachment of tau protein from microtubules is a key cause of many neurodegenerative diseases. Mixtures of environmental pollutants cause tau destabilization in a number of different ways. .

#ecology #publichealth #pets #toxicology #SDGs Widespread contamination of pet food with PFAS. High levels of PFAS in fish-based foods. Emerging PFAS (9Cl-PF3ONS) from F-53B. Analysis of 34 PFAS (forever chemicals) in 100 commercial dog and cat foods www.sciencedirect.com/science/arti...

#health #AI #agedcare #publichealth #ecotoxicology #sustainability #toxicology #SDGs Preventive healthcare AI needs to have the capability to assess synergistic and additive toxic effects of tissue concentrations of environmental pollutant (metabolite) mixtures and combinations of medications. .

#menopause #health #agedcare #publichealth #gerontology #womenshealth #gerontology #aging #healthinformatics #primaryhealthcare #geriatrics #ehealth #healtheconomics #healthliteracy #NCDs Combinations of medications that are myotoxic (cause muscle damage) increase the risk of loss of mobility. .

#health #agedcare #publichealth Muscle adverse events data: ROR 187.38 muscle adverse reactions with fluvastatin+colchicine ROR 159.85 toxic myopathy with statins+colchicine ROR 50.47 necrotizing myositis with statins ROR 32.50 myotoxicity with colchicine www.frontiersin.org/journals/pha...

#health #publichealth #agedcare #diabetes #NCDs #geriatrics #primaryhealthcare #healthliteracy #aging #T2D #T2DM #healthinformatics Canagliflozin shows a 163-fold higher diabetic foot infection signal in adverse events data than other SGLT-2 inhibitors. . www.sciencedirect.com/science/arti...

#health #agedcare #publichealth #NCDs #nephrology (Effects on muscles and bones also need to be investigated.) Higher risk of chronic kidney disease (CKD) and acute kidney injury (AKI) after 5 years with GLP-1 receptor agonists compared to SGLT2 inhibitors. . jamanetwork.com/journals/jam...

#health #ecology #agedcare #neurology #publichealth #ecotoxicology #SDGs #aging The herbicide atrazine is one of the pollutants contributing to Parkinson's disease risk. Atrazine disrupts neuron-microglia crosstalk, driving Parkinsonian motor deficits. . www.sciencedirect.com/science/arti...

#microbiome #health #publichealth #ecology #SDGs #NCDs The triazole fungicide prothioconazole damages the intestinal mucosa and intestinal villi, and causes significant reductions in bacterial metabolites, such as betaine, choline, and methylthioadenosine. . www.sciencedirect.com/science/arti...

#health #agedcare #CVD DEHP binds to PARG, PTGS2, MMP2. DEHP is cytotoxic in cardiomyocytes and renal tubular epithelial cells. Dose -dependent association between urinary DEHP (phthalate plasticizer) metabolites and cardiovascular-kidney-metabolic syndrome . www.sciencedirect.com/science/arti...

#health #ecology #agedcare #publichealth #arthritis #aging #ecotoxicology #SDGs #healthinformatics #exposome #geriatrics The additive and synergistic effects of multiple pollutant exposures are a critical, yet modifiable determinant of osteoarthritis risk. . www.sciencedirect.com/science/arti...

#sustainability #robotics #publichealth #dietetics #health #automation #healthinformatics #aging #mentalhealth #microbiome #nutrition #SDGs #NCDs Population health is supported by evidence-based affordable healthy meal deliveries that measurably reduce systemic inflammation and neuroinflammation.

Anns’s red #Hellebores are in full bloom now and look ready to start making seed.😍 #Flowers #Gardening #Plants #GulfOfMexico #FlowerReport

#health #ecology #publichealth Effects of pollutants on breast epithelial cells: Lead (Pb) and cadmium (Cd) induce cell-type shifts, consistent with the dysregulated cellular plasticity cancer hallmark. Lead (Pb) and arsenic (As) reduce breast cancer survival. . www.biorxiv.org/content/10.6...

#health #SDGs The risk of mantle cell lymphoma is increased by immunosuppressants (prescribed for autoimmune diseases). The risk of autoimmune diseases is increased by environmental pollutants, insufficient sunlight, and insufficient circulating butyrate. Ethical AI reduces incidence rates.

#ecology #sustainability #publichealth #environment #oceans #water #ecotoxicology #ecosystems #SDGs Pesticides and other toxic pollutants trigger harmful algal blooms by killing zooplankton that graze on algae. .

#health #ecology #agedcare #publichealth #cardiology #primaryhealthcare #menopause #exposome #ecotoxicology #pathology #biomarkers #histology Circulating metals most strongly associated with heart disease in older adults: Cadmium in women, copper in men. . www.sciencedirect.com/science/arti...

#microbiome #education #health #mentalhealth #neurology #cytokines Exposure to environmental pollutants, and insufficient circulating gut microbiota-derived SCFAs need to be addressed. Inflammatory markers elevated in young adults with depression: IL-1β, IL-2, IL-4. jamanetwork.com/journals/jam...

The sun came out for a little while yesterday, opening up all the crocuses. There was a symphony of birdsong from the hedge, revealing the friendly garden Robin #SixOnSaturday

#ecology #publichealth #SDGs #exposome #ecotoxicology Using an expanded list of compounds, combined with extensive suspect and de novo non-target screening (SNTS) detects a large number of previously overlooked forever chemicals (PFAS) in surface water. . www.sciencedirect.com/science/arti...

#health #agedcare #neurology #publichealth #hepatology #ecology #ecotoxicology #aging #gerontology #SDGs #etiology #NCDs Forever chemicals PFOA/PFO4DA elevate blood levels of brain-damaging ammonia by reducing the activity of protective CPS1 in the liver. . www.sciencedirect.com/science/arti...

“Come gather the crocus-cups with me, And dream of the summer coming; Saffron, and purple, and snowy white, All awake to the first bees humming.” - Sebastian Evans (1830-1909)

#ecology #health #publichealth #epidemiology #ecotoxicology #epidemiology #healthinformatics Environmental pollutants that upregulate the long isoform PRLR (prolactin receptor) increase women's risk of endometriosis breast cancer, rheumatoid arthritis, multiple sclerosis, lymphoma. .

#health #ecology #agedcare #neurology #publichealth #SDGs The phthalate plasticizer DEHP is one of the pollutants contributing to the development of Alzheimer's disease. DEHP interacts with TUBB4B to promote microtubule-associated tau hyperphosphorylation. . www.sciencedirect.com/science/arti...

#epidemiology #health The risk of lymphoma is increased by - immunotoxic pollutant mixtures, - immunosuppressant medications, failing to address environmental causes of autoimmune diseases (pollutant mixtures, insufficient UV, NIR from sunlight, microbiome dysbiosis). .

#agedcare #sustainability #AI #publichealth The aged care burden is reduced by AI that monitors causes of accelerated degeneration: chronically elevated cortisol, corticosteroids, indoxyl sulfate, toxic metals/elements: As, Cd, F-, Pb, toxic LPS, insufficient gut microbiota-derived butyrate. .

In the garden this week #flower #gardening #bloomscrolling #sixonsaturday

#health #agedcare #ecology #SDGs Cadmium decreased significantly in Egypt, Germany, Saudi Arabia, Spain, France Cadmium and AD mortality increased in South Korea, Japan, Australia. Cadmium increases the risk of Alzheimer's: Analysis of data from 30 countries www.sciencedirect.com/science/arti...

#health #ecology #agedcare #publichealth #oncology #gerontology #SDGs 192 PFAS-related DEGs linked to colon cancer progression 15-gene PFAS-based prognostic model PRAME upregulation by PFOS Association between PFAS (forever chemicals) and colon cancer . www.sciencedirect.com/science/arti...

#health #agedcare #SDGs Healthy ageing requires healthcare that monitors and addresses the body burden of endocrine-disrupting chemicals. Mixed exposure to bisphenols, phthalates, and parabens markedly increases the risk of type 2 diabetes in older adults. . www.sciencedirect.com/science/arti...