Maurits Roorda
@mauritsroorda.bsky.social
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Maurits Roorda
6 months ago
Happy to post a new study on BioRxiv, where we show Integrated Stress Response activation as an off-target effect of multiple clinically evaluated WEE1 inhibitors. Team effort with the lab of Dan Durocher
@durocher1.bsky.social
and many others.
www.biorxiv.org/content/10.1...
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WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response
The WEE1 kinase negatively regulates CDK1/2 to control DNA replication and mitotic entry. Genetic factors that determine sensitivity to WEE1 inhibitors (WEE1i) are largely unknown. A genome-wide inser...
https://www.biorxiv.org/content/10.1101/2025.03.12.642754v1
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Maurits Roorda
Itai Yanai
10 months ago
If you've been meaning to check out the Night Science Podcast, this is the perfect episode to get started with. Everyone is telling me it's our best one yet!
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